Donor substrate binding and enzymatic mechanism of human core α1,6-fucosyltransferase (FUT8) - Kötzler, Miriam P.; Blank, Simon; Bantleon, Frank I.; Spillner, Edzard; Meyer, Bernd (Biochimica et biophysica acta, 2012)
Keywords: biosynthesis; carcinogenesis; Catalysis; colorectal neoplasms; enzyme activity; epitopes; fucose; Fucosyltransferase; Fucosyltransferases - chemistry; Fucosyltransferases - genetics; Fucosyltransferases - isolation & purification; Fucosyltransferases - metabolism; GDP-fucose; Glycosyltransferase; guanine; Guanosine Diphosphate Fucose - metabolism; hepatoma; host-pathogen relationships; Humans; hydrogen bonding; inflammation; Magnetic Resonance Spectroscopy; Models, Molecular; molecular dynamics; Molecular Dynamics Simulation; nuclear magnetic resonance spectroscopy; polysaccharides; prognosis; Protein Conformation; Saturation transfer difference nuclear magnetic resonance; Substrate recognition; Surface Plasmon Resonance; STD; GT-B; Glycosyltransferase; SPC; Saturation transfer difference nuclear magnetic resonance; ADP; OPLS; BSA; FUT8; IDP; SPR; MD; GDP-fucose; GlcNAc; T1; FID; EGF; XDP; MS; RMSF; PME; cePOFUT1; RMSD; Fucosyltransferase; Molecular dynamics simulation; HEK; MALDI TOF; MWCO; NMR; NodZ; VGF; Fcγ; TGFβ; GDP-Fuc; Mes; Substrate recognition