Effect of interferon‐β1b on CXCR4‐dependent chemotaxis in T cells from multiple sclerosis patients

• Published in: Clinical and experimental immunology Vol. 182; no. 2; pp. 162 - 172
• Main Authors: Wostradowski, T., Gudi, V., Pul, R., Gingele, S., Lindquist, J. A., Stangel, M., Lindquist, S.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Ltd 01.11.2015
• Subjects: Adult; Blotting, Western; Cell Movement - drug effects; Cells, Cultured; Chemotaxis - drug effects; CXCL12; CXCR4 expression; Female; Gene Expression - drug effects; Gene Expression - immunology; Humans; Interferon beta-1b - pharmacology; interferon‐β1b; Male; Middle Aged; migration; Multiple Sclerosis, Relapsing-Remitting - genetics; Multiple Sclerosis, Relapsing-Remitting - immunology; primary human T cells; Receptors, CXCR4 - genetics; Receptors, CXCR4 - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - drug effects; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Time Factors; Translational; Young Adult; migration; interferon-β1b; CXCL12; CXCR4 expression; primary human T cells

Summary Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease triggered by infiltration of activated T cells into the central nervous system. Interferon (IFN)‐β is an established, safe and effective treatment for patients with relapsing–remitting MS (RRMS). The cyto...