Persistence of virus-neutralizing antibodies in horses inoculated with two doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals

• Published in: Journal of Equine Science Vol. 32; no. 3; pp. 99 - 102
• Main Authors: BANNAI, Hiroshi, KAMBAYASHI, Yoshinori, TSUJIMURA, Koji, NAGASHIMA, Tsuyoshi, TAKEBE, Naoya, TOMINARI, Masataka, NEMOTO, Manabu, OHTA, Minoru
• Format: Journal Article
• Language: English
• Published: Utsunomiya-shi Japanese Society of Equine Science 2021; Japan Science and Technology Agency; The Japanese Society of Equine Science
• Subjects: Antibodies; Antibody response; equine herpesvirus type-1; Horses; Immunization; Intervals; Neutralizing; persistence; Vaccination; vaccination interval; Vaccines; virus-neutralizing antibody; Viruses
• ISSN: 1340-3516; 1347-7501
• DOI: 10.1294/jes.32.99

The antibody response in horses inoculated with 2 doses of a live equine herpesvirus type 1 vaccine with different vaccination intervals (1 to 3 months) was evaluated with regard to the persistence of virus-neutralizing (VN) antibodies. The durations for which the geometric mean VN titers were maintained significantly higher than those before the first vaccination (P<0.05) were up to 5 months in horses that received the vaccination with a 1-month interval (n=17) and 7 months for those that received it with a 2-month (n=17) or 3-month interval (n=14 or 17). The vaccination program with the 2-month interval was the most effective in maintaining VN antibodies for a long duration with the smallest gap of antibody decline between the first and second vaccinations.