Development of T cells in SCID mice grafted with fetal thymus from AKR mice or F344 rats

• Published in: European journal of immunology Vol. 23; no. 12; p. 3151
• Main Authors: Maeda, K, Nagasawa, H, Furukawa, A, Hisaeda, H, Maekawa, Y, Manabe, T, Kudo, E, Good, R A, Himeno, K
• Format: Journal Article
• Language: English
• Published: Germany 01.12.1993
• Subjects: Animals; Clonal Deletion; Graft vs Host Disease - etiology; Hematopoiesis; Lymphocyte Activation; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, SCID; Phenotype; Rats; Rats, Inbred F344; Superantigens - immunology; T-Lymphocytes - physiology; T-Lymphocytes, Cytotoxic - physiology; Thymus Gland - embryology; Thymus Gland - transplantation; Transplantation, Heterologous; Transplantation, Homologous

To examine the development of T cells within an allogeneic or xenogeneic environment, we engrafted the fetal thymus from AKR mice or F344 rats under the kidney capsule of SCID mice (mTG and rTG mice). T lymphopoiesis developed in SCID mice 2 months after transplantation, although the ratio of CD4/CD...