HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non–Insulin-Treated Type 2 Diabetes

Abstract Context Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density impute...

Full description

Saved in:
Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 105; no. 3; pp. e245 - e254
Main Authors Jacobi, Thomas, Massier, Lucas, Klöting, Nora, Horn, Katrin, Schuch, Alexander, Ahnert, Peter, Engel, Christoph, Löffler, Markus, Burkhardt, Ralph, Thiery, Joachim, Tönjes, Anke, Stumvoll, Michael, Blüher, Matthias, Doxiadis, Ilias, Scholz, Markus, Kovacs, Peter
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.03.2020
Copyright Oxford University Press
Subjects
Alleles
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
DQA1 protein
Drb1 protein
Gene polymorphism
Genetic analysis
Genetic diversity
Genomes
Haplotypes
Histocompatibility antigen HLA
Insulin
Metabolism
Phenotyping
Single-nucleotide polymorphism
type 1 diabetes
haplotype
type 2 diabetes
single nucleotide polymorphism
genotype imputation
HLA class II
association
Online AccessGet full text

Cover

Abstract Abstract Context Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes. Objectives and Design Three cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N = 4815) and the Sorbs (N = 949) cohort. Detailed metabolic phenotyping and genome-wide single nucleotide polymorphism (SNP) data were available for all subjects. Using 1000 Genome imputation data, HLA genotypes were imputed on 4-digit level and association tests for type 2 diabetes, and related metabolic traits were conducted. Results In a meta-analysis including all 3 cohorts, the absence of HLA-DRB5 was associated with increased risk of type 2 diabetes (P = 0.001). In contrast, HLA-DQB*06:02 and HLA-DQA*01:02 had a protective effect on type 2 diabetes (P = 0.005 and 0.003, respectively). Both alleles are part of the well-established type 1 diabetes protective haplotype DRB1*15:01~DQA1*01:02~DQB1*06:02, which was also associated with reduced risk of type 2 diabetes (OR 0.84; P = 0.005). On the contrary, the DRB1*07:01~DQA1*02:01~DQB1*03:03 was identified as a risk haplotype in non–insulin-treated diabetes (OR 1.37; P = 0.002). Conclusions Genetic variation in the HLA class II locus exerts risk and protective effects on non–insulin-treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.
AbstractList Context Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes. Objectives and Design Three cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N = 4815) and the Sorbs (N = 949) cohort. Detailed metabolic phenotyping and genome-wide single nucleotide polymorphism (SNP) data were available for all subjects. Using 1000 Genome imputation data, HLA genotypes were imputed on 4-digit level and association tests for type 2 diabetes, and related metabolic traits were conducted. Results In a meta-analysis including all 3 cohorts, the absence of HLA-DRB5 was associated with increased risk of type 2 diabetes (P = 0.001). In contrast, HLA-DQB*06:02 and HLA-DQA*01:02 had a protective effect on type 2 diabetes (P = 0.005 and 0.003, respectively). Both alleles are part of the well-established type 1 diabetes protective haplotype DRB1*15:01~DQA1*01:02~DQB1*06:02, which was also associated with reduced risk of type 2 diabetes (OR 0.84; P = 0.005). On the contrary, the DRB1*07:01~DQA1*02:01~DQB1*03:03 was identified as a risk haplotype in non–insulin-treated diabetes (OR 1.37; P = 0.002). Conclusions Genetic variation in the HLA class II locus exerts risk and protective effects on non–insulin-treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.
Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes. Three cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N = 4815) and the Sorbs (N = 949) cohort. Detailed metabolic phenotyping and genome-wide single nucleotide polymorphism (SNP) data were available for all subjects. Using 1000 Genome imputation data, HLA genotypes were imputed on 4-digit level and association tests for type 2 diabetes, and related metabolic traits were conducted. In a meta-analysis including all 3 cohorts, the absence of HLA-DRB5 was associated with increased risk of type 2 diabetes (P = 0.001). In contrast, HLA-DQB*06:02 and HLA-DQA*01:02 had a protective effect on type 2 diabetes (P = 0.005 and 0.003, respectively). Both alleles are part of the well-established type 1 diabetes protective haplotype DRB1*15:01~DQA1*01:02~DQB1*06:02, which was also associated with reduced risk of type 2 diabetes (OR 0.84; P = 0.005). On the contrary, the DRB1*07:01~DQA1*02:01~DQB1*03:03 was identified as a risk haplotype in non-insulin-treated diabetes (OR 1.37; P = 0.002). Genetic variation in the HLA class II locus exerts risk and protective effects on non-insulin-treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.
Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes.CONTEXTCommon genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes.Three cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N = 4815) and the Sorbs (N = 949) cohort. Detailed metabolic phenotyping and genome-wide single nucleotide polymorphism (SNP) data were available for all subjects. Using 1000 Genome imputation data, HLA genotypes were imputed on 4-digit level and association tests for type 2 diabetes, and related metabolic traits were conducted.OBJECTIVES AND DESIGNThree cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N = 4815) and the Sorbs (N = 949) cohort. Detailed metabolic phenotyping and genome-wide single nucleotide polymorphism (SNP) data were available for all subjects. Using 1000 Genome imputation data, HLA genotypes were imputed on 4-digit level and association tests for type 2 diabetes, and related metabolic traits were conducted.In a meta-analysis including all 3 cohorts, the absence of HLA-DRB5 was associated with increased risk of type 2 diabetes (P = 0.001). In contrast, HLA-DQB*06:02 and HLA-DQA*01:02 had a protective effect on type 2 diabetes (P = 0.005 and 0.003, respectively). Both alleles are part of the well-established type 1 diabetes protective haplotype DRB1*15:01~DQA1*01:02~DQB1*06:02, which was also associated with reduced risk of type 2 diabetes (OR 0.84; P = 0.005). On the contrary, the DRB1*07:01~DQA1*02:01~DQB1*03:03 was identified as a risk haplotype in non-insulin-treated diabetes (OR 1.37; P = 0.002).RESULTSIn a meta-analysis including all 3 cohorts, the absence of HLA-DRB5 was associated with increased risk of type 2 diabetes (P = 0.001). In contrast, HLA-DQB*06:02 and HLA-DQA*01:02 had a protective effect on type 2 diabetes (P = 0.005 and 0.003, respectively). Both alleles are part of the well-established type 1 diabetes protective haplotype DRB1*15:01~DQA1*01:02~DQB1*06:02, which was also associated with reduced risk of type 2 diabetes (OR 0.84; P = 0.005). On the contrary, the DRB1*07:01~DQA1*02:01~DQB1*03:03 was identified as a risk haplotype in non-insulin-treated diabetes (OR 1.37; P = 0.002).Genetic variation in the HLA class II locus exerts risk and protective effects on non-insulin-treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.CONCLUSIONSGenetic variation in the HLA class II locus exerts risk and protective effects on non-insulin-treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.
Abstract Context Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte antigen (HLA) genotypes with type 2 diabetes. Objectives and Design Three cohorts (Ntotal = 10 413) from Leipzig, Germany were included in this study: LIFE-Adult (N = 4649), LIFE-Heart (N = 4815) and the Sorbs (N = 949) cohort. Detailed metabolic phenotyping and genome-wide single nucleotide polymorphism (SNP) data were available for all subjects. Using 1000 Genome imputation data, HLA genotypes were imputed on 4-digit level and association tests for type 2 diabetes, and related metabolic traits were conducted. Results In a meta-analysis including all 3 cohorts, the absence of HLA-DRB5 was associated with increased risk of type 2 diabetes (P = 0.001). In contrast, HLA-DQB*06:02 and HLA-DQA*01:02 had a protective effect on type 2 diabetes (P = 0.005 and 0.003, respectively). Both alleles are part of the well-established type 1 diabetes protective haplotype DRB1*15:01~DQA1*01:02~DQB1*06:02, which was also associated with reduced risk of type 2 diabetes (OR 0.84; P = 0.005). On the contrary, the DRB1*07:01~DQA1*02:01~DQB1*03:03 was identified as a risk haplotype in non–insulin-treated diabetes (OR 1.37; P = 0.002). Conclusions Genetic variation in the HLA class II locus exerts risk and protective effects on non–insulin-treated type 2 diabetes. Our data suggest that the genetic architecture of type 1 diabetes and type 2 diabetes might share common components on the HLA class II locus.
Author Schuch, Alexander
Thiery, Joachim
Engel, Christoph
Scholz, Markus
Massier, Lucas
Tönjes, Anke
Ahnert, Peter
Jacobi, Thomas
Blüher, Matthias
Horn, Katrin
Kovacs, Peter
Löffler, Markus
Doxiadis, Ilias
Klöting, Nora
Burkhardt, Ralph
Stumvoll, Michael
AuthorAffiliation University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany Institute of Laboratory Medicine and Clinical Chemistry, University of Leipzig, Leipzig, Germany Medical Department III – Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Germany Institute for Transfusion Medicine, University Hospital of Leipzig, Leipzig, Germany
AuthorAffiliation_xml – name: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany Institute of Laboratory Medicine and Clinical Chemistry, University of Leipzig, Leipzig, Germany Medical Department III – Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Germany Institute for Transfusion Medicine, University Hospital of Leipzig, Leipzig, Germany
Author_xml – sequence: 1
  givenname: Thomas
  surname: Jacobi
  fullname: Jacobi, Thomas
  organization: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
– sequence: 2
  givenname: Lucas
  surname: Massier
  fullname: Massier, Lucas
  organization: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
– sequence: 3
  givenname: Nora
  surname: Klöting
  fullname: Klöting, Nora
  organization: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
– sequence: 4
  givenname: Katrin
  surname: Horn
  fullname: Horn, Katrin
  organization: Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
– sequence: 5
  givenname: Alexander
  surname: Schuch
  fullname: Schuch, Alexander
  organization: Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
– sequence: 6
  givenname: Peter
  surname: Ahnert
  fullname: Ahnert, Peter
  organization: Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
– sequence: 7
  givenname: Christoph
  surname: Engel
  fullname: Engel, Christoph
  organization: Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
– sequence: 8
  givenname: Markus
  surname: Löffler
  fullname: Löffler, Markus
  organization: Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
– sequence: 9
  givenname: Ralph
  surname: Burkhardt
  fullname: Burkhardt, Ralph
  organization: LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany
– sequence: 10
  givenname: Joachim
  surname: Thiery
  fullname: Thiery, Joachim
  organization: LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany
– sequence: 11
  givenname: Anke
  surname: Tönjes
  fullname: Tönjes, Anke
  organization: Medical Department III – Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany
– sequence: 12
  givenname: Michael
  surname: Stumvoll
  fullname: Stumvoll, Michael
  organization: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
– sequence: 13
  givenname: Matthias
  surname: Blüher
  fullname: Blüher, Matthias
  organization: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
– sequence: 14
  givenname: Ilias
  surname: Doxiadis
  fullname: Doxiadis, Ilias
  organization: Institute for Transfusion Medicine, University Hospital of Leipzig, Leipzig, Germany
– sequence: 15
  givenname: Markus
  surname: Scholz
  fullname: Scholz, Markus
  organization: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
– sequence: 16
  givenname: Peter
  orcidid: 0000-0002-0290-5423
  surname: Kovacs
  fullname: Kovacs, Peter
  email: peter.kovacs@medizin.uni-leipzig.de
  organization: University of Leipzig Medical Center, IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31974565$$D View this record in MEDLINE/PubMed
BookMark eNqFkc9qGzEQh0VJSZw01x6LoJf2sIn-7co-GqdNDKa5ONCbkFezjVKttJW0BN_6Dn3DPkkV1rkEQk9Co-8bDb85RUc-eEDoPSUXlFFy2Trrob80P7QmTL5BM7oQdSXpQh6hGSGMVgvJvp-g05QeCKFC1PwYnfDyLuqmnqF8s1nildMp4fUaL50DB3jptdsnKKV-cLbVGfAq9H3w-Bo8ZNs-XYcyiM8JW4-3-wEwxdob_C34v7__rH0ay2DVNkKRzQQwfGX1DjKkd-htp12C88N5hu6-ftmubqrN7fV6tdxUrSBEVrLtOm5auQBCdNOQuaCcdqaZAyVNLRhh2jSMciPnRJRSCYTKel6Lne6EEIafoU9T3yGGXyOkrHqbWnBOewhjUowLwaRouCzoxxfoQxhjyaFQgtOSbU1IoT4cqHHXg1FDtL2Oe_WcZwHEBLQxpBShU63NOtvgc9TWKUrU09rUtDZ1WFvRLl5oz51fFdgkPAaXIaafbnyEqO5Bu3z_uvR5ksI4_O-DfyrRuhQ
CitedBy_id crossref_primary_10_2174_1871530323666221111153102
crossref_primary_10_3390_genes13050772
crossref_primary_10_2337_dc21_1238
crossref_primary_10_1155_2022_9710376
crossref_primary_10_3390_jcm11061690
crossref_primary_10_1007_s10142_022_00881_5
crossref_primary_10_3389_fendo_2022_842673
crossref_primary_10_3389_fnins_2020_00670
crossref_primary_10_3390_ijms23126481
crossref_primary_10_1016_j_metabol_2024_155917
crossref_primary_10_1371_journal_pone_0275934
crossref_primary_10_3389_fimmu_2024_1501660
Cites_doi 10.1371/journal.pcbi.1002877
10.1186/1471-2156-12-67
10.1111/j.1744-313X.2006.00581.x
10.1155/2013/452537
10.1086/282771
10.1002/jmri.26754
10.1097/MD.0000000000003858
10.1084/jem.179.1.279
10.2337/db07-1331
10.1016/j.cmet.2013.02.009
10.2337/db16-1253
10.1093/nar/gku1166
10.1038/srep35005
10.2337/db15-1115
10.1007/BF00399956
10.2337/db18-0501
10.1007/s00125-016-4139-5
10.4049/jimmunol.160.7.3363
10.3389/fimmu.2017.00984
10.2337/diacare.24.4.796
10.2337/dc18-S002
10.1093/hmg/ddp423
10.2337/diabetes.48.1.150
10.1373/clinchem.2010.148270
10.2337/db13-1153
10.1111/cei.12687
10.1038/tpj.2013.18
10.4049/jimmunol.159.2.703
10.1371/journal.pone.0172444
10.7717/peerj.281
10.1038/ng1885
10.3324/haematol.2017.179119
10.1007/s00125-011-2122-8
10.2337/diabetes.48.5.983
10.1371/journal.pone.0029070
10.1111/j.1745-7599.2009.00399.x
10.1038/ng.3943
10.1186/s12889-015-1983-z
10.1371/journal.pgen.1005510
10.1016/S0198-8859(99)00146-9
10.1111/j.1463-1326.2008.00950.x
10.1007/s00125-006-0513-z
10.1007/s001250051202
10.1016/0197-2456(86)90046-2
10.1210/jc.2003-032084
10.1016/j.celrep.2014.09.004
10.2337/diabetes.54.suppl_2.S40
10.1007/s00251-011-0513-0
10.1016/S2213-8587(18)30051-2
10.1136/bmj.307.6897.155
10.1002/sim.1186
10.1016/j.humimm.2015.12.006
10.1007/s00125-003-1070-3
10.1007/BF00280883
10.2337/dc08-s243
10.4049/jimmunol.153.4.1665
10.1089/152091504774198124
10.4049/jimmunol.160.5.2365
10.1038/ejhg.2009.107
10.1016/j.clim.2005.08.017
10.1093/bioinformatics/bty633
10.1007/BF00401370
ContentType Journal Article
Copyright Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020
Copyright © Oxford University Press 2015
Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Copyright_xml – notice: Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020
– notice: Copyright © Oxford University Press 2015
– notice: Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
DBID AAYXX
CITATION
NPM
3V.
7QP
7T5
7TM
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FYUFA
GHDGH
H94
K9.
M0S
M1P
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
DOI 10.1210/clinem/dgaa027
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Immunology Abstracts
Nucleic Acids Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central
ProQuest One
Health Research Premium Collection
Health Research Premium Collection (Alumni)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
ProQuest One Academic Middle East (New)
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Health & Medical Research Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList ProQuest One Academic Middle East (New)
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1945-7197
EndPage e254
ExternalDocumentID 31974565
10_1210_clinem_dgaa027
10.1210/clinem/dgaa027
Genre Journal Article
GroupedDBID ---
-~X
.55
.GJ
.XZ
08P
0R~
18M
1TH
29K
2WC
34G
354
39C
3O-
4.4
48X
53G
5GY
5RS
5YH
7X7
88E
8F7
8FI
8FJ
AABZA
AACZT
AAIMJ
AAJQQ
AAKAS
AAPGJ
AAPQZ
AAPXW
AAQQT
AARHZ
AAUAY
AAUQX
AAVAP
AAWDT
AAWTL
AAYJJ
ABBLC
ABDFA
ABDPE
ABEJV
ABGNP
ABJNI
ABLJU
ABMNT
ABNHQ
ABOCM
ABPMR
ABPPZ
ABPQP
ABPTD
ABQNK
ABUWG
ABVGC
ABWST
ABXVV
ABXZS
ACFRR
ACGFO
ACGFS
ACPRK
ACUTJ
ACVCV
ACYHN
ACZBC
ADBBV
ADGKP
ADGZP
ADHKW
ADMTO
ADNBA
ADQBN
ADRTK
ADVEK
ADZCM
AELWJ
AEMDU
AEMQT
AENEX
AENZO
AERZD
AETBJ
AEWNT
AFCHL
AFFNX
AFFQV
AFFZL
AFGWE
AFKRA
AFOFC
AFRAH
AFXAL
AFYAG
AGINJ
AGKRT
AGMDO
AGQXC
AGUTN
AHMBA
AHMMS
AI.
AJDVS
AJEEA
ALMA_UNASSIGNED_HOLDINGS
ALXQX
APIBT
APJGH
AQDSO
AQKUS
ARIXL
ASPBG
ATGXG
AVNTJ
AVWKF
AZFZN
BAWUL
BAYMD
BCRHZ
BENPR
BEYMZ
BPHCQ
BSWAC
BTRTY
BVXVI
C45
CCPQU
CDBKE
CS3
D-I
DAKXR
DIK
E3Z
EBS
EIHJH
EJD
EMOBN
ENERS
F5P
FECEO
FEDTE
FHSFR
FLUFQ
FOEOM
FOTVD
FQBLK
FYUFA
GAUVT
GJXCC
GX1
H13
HMCUK
HVGLF
HZ~
H~9
IAO
IHR
INH
ITC
J5H
KBUDW
KOP
KSI
KSN
L7B
M1P
M5~
MBLQV
MHKGH
MJL
N4W
N9A
NLBLG
NOMLY
NOYVH
NVLIB
O9-
OAUYM
OBFPC
OBH
OCB
ODMLO
OFXIZ
OGEVE
OHH
OJZSN
OK1
OPAEJ
OVD
OVIDX
P2P
P6G
PHGZT
PQQKQ
PROAC
PSQYO
REU
ROX
ROZ
TEORI
TJX
TLC
TMA
TR2
TWZ
UKHRP
VH1
VVN
W8F
WHG
WOQ
X52
X7M
YBU
YFH
YHG
YOC
YSK
ZGI
ZXP
ZY1
~02
~H1
AEOTA
AGORE
AJBYB
NU-
PHGZM
AAYXX
AHGBF
CITATION
KQ8
NPM
3V.
7QP
7T5
7TM
7XB
8FK
H94
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
ID FETCH-LOGICAL-c4007-7cff3dc79e00a66084131fd68e10654202ad6213d7804106121175854baf444d3
IEDL.DBID 7X7
ISSN 0021-972X
1945-7197
IngestDate Thu Jul 10 22:22:13 EDT 2025
Fri Jul 25 21:59:26 EDT 2025
Wed Feb 19 02:31:14 EST 2025
Tue Jul 01 01:10:55 EDT 2025
Thu Apr 24 22:58:24 EDT 2025
Fri May 16 03:41:27 EDT 2025
Wed Apr 02 07:02:00 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords type 1 diabetes
haplotype
type 2 diabetes
single nucleotide polymorphism
genotype imputation
HLA class II
association
Language English
License This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4007-7cff3dc79e00a66084131fd68e10654202ad6213d7804106121175854baf444d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-0290-5423
PMID 31974565
PQID 2431027500
PQPubID 2046206
ParticipantIDs proquest_miscellaneous_2344274637
proquest_journals_2431027500
pubmed_primary_31974565
crossref_citationtrail_10_1210_clinem_dgaa027
crossref_primary_10_1210_clinem_dgaa027
wolterskluwer_health_10_1210_clinem_dgaa027
oup_primary_10_1210_clinem_dgaa027
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-03-01
PublicationDateYYYYMMDD 2020-03-01
PublicationDate_xml – month: 03
  year: 2020
  text: 2020-03-01
  day: 01
PublicationDecade 2020
PublicationPlace US
PublicationPlace_xml – name: US
– name: United States
– name: Washington
PublicationTitle The journal of clinical endocrinology and metabolism
PublicationTitleAlternate J Clin Endocrinol Metab
PublicationYear 2020
Publisher Oxford University Press
Copyright Oxford University Press
Publisher_xml – name: Oxford University Press
– name: Copyright Oxford University Press
References Stumvoll (2021122102015822900_CIT0032) 2001; 24
Karnes (2021122102015822900_CIT0016) 2017; 12
Raddrizzani (2021122102015822900_CIT0062) 1997; 159
Loeffler (2021122102015822900_CIT0017) 2015; 15
Nomura (2021122102015822900_CIT0041) 2006; 33
de Bakker (2021122102015822900_CIT0015) 2006; 38
R Core Team (2021122102015822900_CIT0025) 2018
Sanjeevi (2021122102015822900_CIT0038) 2000; 61
Nei (2021122102015822900_CIT0027) 1972; 106
Donath (2021122102015822900_CIT0049) 2008; 31 Suppl 2
Astill (2021122102015822900_CIT0055) 2003; 46
Lambert (2021122102015822900_CIT0003) 2004; 89
González-Galarza (2021122102015822900_CIT0026) 2015; 43
Tuomi (2021122102015822900_CIT0053) 1999; 48
van Lummel (2021122102015822900_CIT0066) 2019; 68
Brooks-Worrell (2021122102015822900_CIT0043) 1999; 48
Böni-Schnetzler (2021122102015822900_CIT0048) 2008; 10
Williams (2021122102015822900_CIT0013) 2011; 54
Beutner (2021122102015822900_CIT0018) 2011; 6
Gross (2021122102015822900_CIT0023) 2011; 12
Hrdinová (2021122102015822900_CIT0057) 2018; 103
Guo (2021122102015822900_CIT0011) 2016; 6
Horton (2021122102015822900_CIT0010) 1999; 42
Paradis (2021122102015822900_CIT0029) 2019; 35
Schwarzer (2021122102015822900_CIT0034) 2007; 7
Zavala (2021122102015822900_CIT0044) 1992; 35
Tönjes (2021122102015822900_CIT0021) 2010; 18
Cho (2021122102015822900_CIT0005) 2014; 9
Pfützner (2021122102015822900_CIT0065) 2004; 6
Ma (2021122102015822900_CIT0040) 2013; 2013
Tönjes (2021122102015822900_CIT0020) 2009; 18
DerSimonian (2021122102015822900_CIT0035) 1986; 7
Roark (2021122102015822900_CIT0039) 2014; 63
Rich (2021122102015822900_CIT0008) 1993; 36
Wucherpfennig (2021122102015822900_CIT0061) 1994; 179
Ahlqvist (2021122102015822900_CIT0006) 2018; 6
Erlich (2021122102015822900_CIT0054) 2008; 57
Barbosa (2021122102015822900_CIT0058) 2006; 118
Pappas (2021122102015822900_CIT0037) 2016; 77
de Vries (2021122102015822900_CIT0056) 2017; 60
Massier (2021122102015822900_CIT0050)
Southwood (2021122102015822900_CIT0059) 1998; 160
American Diabetes Association 2 (2021122102015822900_CIT0022) 2018; 41
Zhao (2021122102015822900_CIT0014) 2017; 49
Viechtbauer (2021122102015822900_CIT0033) 2010
Chen (2021122102015822900_CIT0046) 2019; 50
Vogt (2021122102015822900_CIT0060) 1994; 153
Tuomilehto-Wolf (2021122102015822900_CIT0009) 1993; 307
Matthews (2021122102015822900_CIT0031) 1985; 28
Tuomi (2021122102015822900_CIT0007) 2005; 54 Suppl 2
Desai (2021122102015822900_CIT0002) 2007; 50
Deng (2021122102015822900_CIT0004) 2013; 17
Zheng (2021122102015822900_CIT0030) 2014; 14
Gibson (2021122102015822900_CIT0064) 2015; 182
Scott (2021122102015822900_CIT0012) 2017; 66
Zhao (2021122102015822900_CIT0051) 2016; 65
Appel (2021122102015822900_CIT0042) 2009; 21
Brooks-Worrell (2021122102015822900_CIT0045) 2011; 57
Ettinger (2021122102015822900_CIT0063) 1998; 160
Greenbaum (2021122102015822900_CIT0001) 2011; 63
Dilthey (2021122102015822900_CIT0024) 2013; 9
Burkhardt (2021122102015822900_CIT0019) 2015; 11
Higgins (2021122102015822900_CIT0036) 2002; 21
Scholz (2021122102015822900_CIT0052) 2017; 8
Kamvar (2021122102015822900_CIT0028) 2014; 2
Dong (2021122102015822900_CIT0047) 2016; 95
References_xml – volume: 9
  start-page: e1002877
  issue: 2
  year: 2013
  ident: 2021122102015822900_CIT0024
  article-title: Multi-population classical HLA type imputation
  publication-title: Plos Comput Biol.
  doi: 10.1371/journal.pcbi.1002877
– volume: 12
  start-page: 67
  year: 2011
  ident: 2021122102015822900_CIT0023
  article-title: Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays
  publication-title: BMC Genet.
  doi: 10.1186/1471-2156-12-67
– volume: 33
  start-page: 117
  issue: 2
  year: 2006
  ident: 2021122102015822900_CIT0041
  article-title: Genetic analysis of HLA, NA and HPA typing in type 2 diabetes and ASO
  publication-title: Int J Immunogenet.
  doi: 10.1111/j.1744-313X.2006.00581.x
– volume: 2013
  start-page: 452537
  year: 2013
  ident: 2021122102015822900_CIT0040
  article-title: Association of the HLA-DQA1 and HLA-DQB1 alleles in type 2 diabetes mellitus and diabetic nephropathy in the han ethnicity of China
  publication-title: J Diabetes Res.
  doi: 10.1155/2013/452537
– volume: 106
  start-page: 283
  year: 1972
  ident: 2021122102015822900_CIT0027
  article-title: Genetic distance between populations
  publication-title: The American Naturalist
  doi: 10.1086/282771
– volume: 50
  start-page: 1905
  issue: 6
  year: 2019
  ident: 2021122102015822900_CIT0046
  article-title: Magnetic resonance imaging: proton density fat fraction for assessment of pancreatic fatty infiltration during progression of T2DM bama minipigs
  publication-title: J Magn Reson Imaging
  doi: 10.1002/jmri.26754
– volume: 95
  issue: 23
  year: 2016
  ident: 2021122102015822900_CIT0047
  article-title: Noninvasive fat quantification of the liver and pancreas may provide potential biomarkers of impaired glucose tolerance and type 2 diabetes
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000003858
– volume: 179
  start-page: 279
  year: 1994
  ident: 2021122102015822900_CIT0061
  article-title: Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones
  publication-title: Journal of Experimental Medicine
  doi: 10.1084/jem.179.1.279
– volume: 57
  start-page: 1084
  issue: 4
  year: 2008
  ident: 2021122102015822900_CIT0054
  article-title: HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families
  publication-title: Diabetes.
  doi: 10.2337/db07-1331
– volume: 17
  start-page: 411
  issue: 3
  year: 2013
  ident: 2021122102015822900_CIT0004
  article-title: Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.02.009
– volume: 66
  start-page: 2888
  issue: 11
  year: 2017
  ident: 2021122102015822900_CIT0012
  article-title: An expanded genome-wide association study of type 2 diabetes in Europeans
  publication-title: Diabetes.
  doi: 10.2337/db16-1253
– volume: 43
  start-page: D784
  issue: Database issue
  year: 2015
  ident: 2021122102015822900_CIT0026
  article-title: Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1166
– volume: 6
  start-page: 35005
  year: 2016
  ident: 2021122102015822900_CIT0011
  article-title: The relationships between HLA class II alleles and antigens with gestational diabetes mellitus: a meta-analysis
  publication-title: Sci Rep.
  doi: 10.1038/srep35005
– volume: 65
  start-page: 710
  issue: 3
  year: 2016
  ident: 2021122102015822900_CIT0051
  article-title: Next-generation sequencing reveals that HLA-DRB3, -DRB4, and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes
  publication-title: Diabetes.
  doi: 10.2337/db15-1115
– volume: 36
  start-page: 234
  issue: 3
  year: 1993
  ident: 2021122102015822900_CIT0008
  article-title: HLA-associated susceptibility to type 2 (non-insulin-dependent) diabetes mellitus: the Wadena City Health Study
  publication-title: Diabetologia.
  doi: 10.1007/BF00399956
– volume: 68
  start-page: 787
  issue: 4
  year: 2019
  ident: 2021122102015822900_CIT0066
  article-title: Epitope stealing as a mechanism of dominant protection by HLA-DQ6 in type 1 diabetes
  publication-title: Diabetes.
  doi: 10.2337/db18-0501
– volume: 60
  start-page: 280
  year: 2017
  ident: 2021122102015822900_CIT0056
  article-title: ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study
  publication-title: Diabetologia
  doi: 10.1007/s00125-016-4139-5
– volume: 160
  start-page: 3363
  year: 1998
  ident: 2021122102015822900_CIT0059
  article-title: Several common HLA-DR types share largely overlapping peptide binding repertoires
  publication-title: The Journal of Immunology
  doi: 10.4049/jimmunol.160.7.3363
– volume: 8
  start-page: 984
  year: 2017
  ident: 2021122102015822900_CIT0052
  article-title: Human leukocyte antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 present complementary peptide repertoires
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.00984
– volume: 24
  start-page: 796
  issue: 4
  year: 2001
  ident: 2021122102015822900_CIT0032
  article-title: Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times
  publication-title: Diabetes Care.
  doi: 10.2337/diacare.24.4.796
– volume: 41
  start-page: S13
  year: 2018
  ident: 2021122102015822900_CIT0022
  article-title: Classification and diagnosis of diabetes: standards of medical care in diabetes—2018
  publication-title: Diabetes Care
  doi: 10.2337/dc18-S002
– volume: 18
  start-page: 4662
  issue: 23
  year: 2009
  ident: 2021122102015822900_CIT0020
  article-title: Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs
  publication-title: Hum Mol Genet.
  doi: 10.1093/hmg/ddp423
– volume: 48
  start-page: 150
  issue: 1
  year: 1999
  ident: 2021122102015822900_CIT0053
  article-title: Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies
  publication-title: Diabetes.
  doi: 10.2337/diabetes.48.1.150
– volume: 57
  start-page: 158
  issue: 2
  year: 2011
  ident: 2021122102015822900_CIT0045
  article-title: Is diabetes mellitus a continuous spectrum?
  publication-title: Clin Chem.
  doi: 10.1373/clinchem.2010.148270
– volume: 63
  start-page: 323
  issue: 1
  year: 2014
  ident: 2021122102015822900_CIT0039
  article-title: Multiple HLA epitopes contribute to type 1 diabetes susceptibility
  publication-title: Diabetes.
  doi: 10.2337/db13-1153
– volume: 182
  start-page: 251
  issue: 3
  year: 2015
  ident: 2021122102015822900_CIT0064
  article-title: Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model
  publication-title: Clin Exp Immunol.
  doi: 10.1111/cei.12687
– volume: 14
  start-page: 192
  issue: 2
  year: 2014
  ident: 2021122102015822900_CIT0030
  article-title: HIBAG–HLA genotype imputation with attribute bagging
  publication-title: Pharmacogenomics J.
  doi: 10.1038/tpj.2013.18
– volume: 159
  start-page: 703
  year: 1997
  ident: 2021122102015822900_CIT0062
  article-title: Different modes of peptide interaction enable HLA-DQ and HLA-DR molecules to bind diverse peptide repertoires
  publication-title: The Journal of Immunology
  doi: 10.4049/jimmunol.159.2.703
– volume: 12
  start-page: e0172444
  issue: 2
  year: 2017
  ident: 2021122102015822900_CIT0016
  article-title: Comparison of HLA allelic imputation programs
  publication-title: Plos One.
  doi: 10.1371/journal.pone.0172444
– volume: 2
  start-page: e281
  year: 2014
  ident: 2021122102015822900_CIT0028
  article-title: Poppr: an R package for genetic analysis of populations with clonal, partially clonal, and/or sexual reproduction
  publication-title: Peerj.
  doi: 10.7717/peerj.281
– volume: 38
  start-page: 1166
  issue: 10
  year: 2006
  ident: 2021122102015822900_CIT0015
  article-title: A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
  publication-title: Nat Genet.
  doi: 10.1038/ng1885
– volume: 103
  start-page: 1083
  issue: 6
  year: 2018
  ident: 2021122102015822900_CIT0057
  article-title: Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ
  publication-title: Haematologica.
  doi: 10.3324/haematol.2017.179119
– volume: 54
  start-page: 1684
  issue: 7
  year: 2011
  ident: 2021122102015822900_CIT0013
  article-title: HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion
  publication-title: Diabetologia.
  doi: 10.1007/s00125-011-2122-8
– volume: 48
  start-page: 983
  issue: 5
  year: 1999
  ident: 2021122102015822900_CIT0043
  article-title: Cellular immune responses to human islet proteins in antibody- positive type 2 diabetic patients
  publication-title: Diabetes.
  doi: 10.2337/diabetes.48.5.983
– volume-title: R: A Language and Environment for Statistical Computing
  year: 2018
  ident: 2021122102015822900_CIT0025
– volume: 6
  start-page: e29070
  issue: 12
  year: 2011
  ident: 2021122102015822900_CIT0018
  article-title: Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease
  publication-title: Plos One.
  doi: 10.1371/journal.pone.0029070
– volume: 21
  start-page: 156
  issue: 3
  year: 2009
  ident: 2021122102015822900_CIT0042
  article-title: Latent autoimmune diabetes of adulthood (LADA): an often misdiagnosed type of diabetes mellitus
  publication-title: J Am Acad Nurse Pract.
  doi: 10.1111/j.1745-7599.2009.00399.x
– year: 2010
  ident: 2021122102015822900_CIT0033
  article-title: Conducting meta-analyses in R with the metafor package
– volume: 49
  start-page: 1450
  issue: 10
  year: 2017
  ident: 2021122102015822900_CIT0014
  article-title: Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
  publication-title: Nat Genet.
  doi: 10.1038/ng.3943
– volume: 15
  start-page: 691
  year: 2015
  ident: 2021122102015822900_CIT0017
  article-title: The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10 000 deeply phenotyped adults in Germany
  publication-title: BMC Public Health.
  doi: 10.1186/s12889-015-1983-z
– volume: 11
  start-page: e1005510
  issue: 9
  year: 2015
  ident: 2021122102015822900_CIT0019
  article-title: Integration of genome-wide SNP data and gene-expression profiles reveals six novel loci and regulatory mechanisms for amino acids and acylcarnitines in whole blood
  publication-title: Plos Genet.
  doi: 10.1371/journal.pgen.1005510
– volume: 61
  start-page: 148
  issue: 2
  year: 2000
  ident: 2021122102015822900_CIT0038
  article-title: HLA-DQ6-mediated protection in IDDM
  publication-title: Hum Immunol.
  doi: 10.1016/S0198-8859(99)00146-9
– volume: 10
  start-page: 201
  year: 2008
  ident: 2021122102015822900_CIT0048
  article-title: Insulitis in type 2 diabetes
  publication-title: Diabetes, Obesity and Metabolism
  doi: 10.1111/j.1463-1326.2008.00950.x
– volume: 50
  start-page: 68
  issue: 1
  year: 2007
  ident: 2021122102015822900_CIT0002
  article-title: An association analysis of the HLA gene region in latent autoimmune diabetes in adults
  publication-title: Diabetologia.
  doi: 10.1007/s00125-006-0513-z
– volume: 42
  start-page: 608
  issue: 5
  year: 1999
  ident: 2021122102015822900_CIT0010
  article-title: Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group
  publication-title: Diabetologia.
  doi: 10.1007/s001250051202
– volume: 7
  start-page: 177
  issue: 3
  year: 1986
  ident: 2021122102015822900_CIT0035
  article-title: Meta-analysis in clinical trials
  publication-title: Control Clin Trials.
  doi: 10.1016/0197-2456(86)90046-2
– volume: 89
  start-page: 4037
  issue: 8
  year: 2004
  ident: 2021122102015822900_CIT0003
  article-title: Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom
  publication-title: J Clin Endocrinol Metab.
  doi: 10.1210/jc.2003-032084
– volume: 9
  start-page: 605
  issue: 2
  year: 2014
  ident: 2021122102015822900_CIT0005
  article-title: An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.09.004
– volume: 54 Suppl 2
  start-page: S40
  year: 2005
  ident: 2021122102015822900_CIT0007
  article-title: Type 1 and type 2 diabetes: what do they have in common?
  publication-title: Diabetes.
  doi: 10.2337/diabetes.54.suppl_2.S40
– volume: 7
  start-page: 40
  year: 2007
  ident: 2021122102015822900_CIT0034
  article-title: meta: an R package for meta-analysis
  publication-title: R News
– volume: 63
  start-page: 325
  issue: 6
  year: 2011
  ident: 2021122102015822900_CIT0001
  article-title: Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes
  publication-title: Immunogenetics.
  doi: 10.1007/s00251-011-0513-0
– volume: 6
  start-page: 361
  issue: 5
  year: 2018
  ident: 2021122102015822900_CIT0006
  article-title: Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
  publication-title: Lancet Diabetes Endocrinol.
  doi: 10.1016/S2213-8587(18)30051-2
– volume: 307
  start-page: 155
  issue: 6897
  year: 1993
  ident: 2021122102015822900_CIT0009
  article-title: Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA region
  publication-title: Bmj.
  doi: 10.1136/bmj.307.6897.155
– volume: 21
  start-page: 1539
  issue: 11
  year: 2002
  ident: 2021122102015822900_CIT0036
  article-title: Quantifying heterogeneity in a meta-analysis
  publication-title: Stat Med.
  doi: 10.1002/sim.1186
– volume: 77
  start-page: 283
  issue: 3
  year: 2016
  ident: 2021122102015822900_CIT0037
  article-title: Bridging immunogenomic data analysis workflow gaps (BIGDAWG): an integrated case-control analysis pipeline
  publication-title: Hum Immunol.
  doi: 10.1016/j.humimm.2015.12.006
– volume: 46
  start-page: 496
  issue: 4
  year: 2003
  ident: 2021122102015822900_CIT0055
  article-title: Promiscuous binding of proinsulin peptides to Type 1 diabetes-permissive and -protective HLA class II molecules
  publication-title: Diabetologia.
  doi: 10.1007/s00125-003-1070-3
– volume: 28
  start-page: 412
  issue: 7
  year: 1985
  ident: 2021122102015822900_CIT0031
  article-title: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
  publication-title: Diabetologia.
  doi: 10.1007/BF00280883
– volume: 31 Suppl 2
  start-page: S161
  year: 2008
  ident: 2021122102015822900_CIT0049
  article-title: Islet inflammation in type 2 diabetes: from metabolic stress to therapy
  publication-title: Diabetes Care.
  doi: 10.2337/dc08-s243
– volume: 153
  start-page: 1665
  year: 1994
  ident: 2021122102015822900_CIT0060
  article-title: Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides
  publication-title: The Journal of Immunology
  doi: 10.4049/jimmunol.153.4.1665
– volume: 6
  start-page: 405
  issue: 3
  year: 2004
  ident: 2021122102015822900_CIT0065
  article-title: Role of intact proinsulin in diagnosis and treatment of type 2 diabetes mellitus
  publication-title: Diabetes Technol Ther.
  doi: 10.1089/152091504774198124
– volume: 160
  start-page: 2365
  year: 1998
  ident: 2021122102015822900_CIT0063
  article-title: A peptide binding Motif for HLA-DQA1*0102/DQB1*0602, the class II MHC molecule associated with dominant protection in insulin-dependent diabetes mellitus
  publication-title: The Journal of Immunology
  doi: 10.4049/jimmunol.160.5.2365
– volume: 18
  start-page: 104
  issue: 1
  year: 2010
  ident: 2021122102015822900_CIT0021
  article-title: Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
  publication-title: Eur J Hum Genet.
  doi: 10.1038/ejhg.2009.107
– volume: 118
  start-page: 42
  issue: 1
  year: 2006
  ident: 2021122102015822900_CIT0058
  article-title: Clinical link between MHC class II haplotype and interferon-beta (IFN-beta) immunogenicity
  publication-title: Clin Immunol.
  doi: 10.1016/j.clim.2005.08.017
– volume: 35
  start-page: 526
  issue: 3
  year: 2019
  ident: 2021122102015822900_CIT0029
  article-title: ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R
  publication-title: Bioinformatics.
  doi: 10.1093/bioinformatics/bty633
– ident: 2021122102015822900_CIT0050
  article-title: Data from: HLA Class II allele analyses implicate common genetic components in type 1 and non–insulin-treated type 2 diabetes.
– volume: 35
  start-page: 1159
  issue: 12
  year: 1992
  ident: 2021122102015822900_CIT0044
  article-title: Cellular and humoural autoimmunity markers in type 2 (non-insulin-dependent) diabetic patients with secondary drug failure
  publication-title: Diabetologia.
  doi: 10.1007/BF00401370
SSID ssj0014453
Score 2.4122102
Snippet Abstract Context Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of...
Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II...
Context Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class...
SourceID proquest
pubmed
crossref
wolterskluwer
oup
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage e245
SubjectTerms Alleles
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
DQA1 protein
Drb1 protein
Gene polymorphism
Genetic analysis
Genetic diversity
Genomes
Haplotypes
Histocompatibility antigen HLA
Insulin
Metabolism
Phenotyping
Single-nucleotide polymorphism
Title HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non–Insulin-Treated Type 2 Diabetes
URI https://www.ncbi.nlm.nih.gov/pubmed/31974565
https://www.proquest.com/docview/2431027500
https://www.proquest.com/docview/2344274637
Volume 105
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1fT9swED_xR0IghAaMrcCQNyHxMFmzY9cpT6hMoBaNakIg9S1yYmdCq5KytuKV78A35JNwl7ilPDAek5wcK3exf-e7-x3AoUylQxRquEvTjGv0IXhLy4wrl5tmemyFshTRveyZzo2-6Df74cBtFNIqp2titVC7MqMz8h8R7nQUYhPiZHjHqWsURVdDC41FWCbqMrLquD9zuNBXCCyUlIYQR_1A2khVK1R36HH0P9YK6igztym9KnSbw5trsH5fUgh79LfKYJ_bh84_wEYAkKxda3wTFnyxBSuXIUS-DePOrzarWl2ybpe1BwPcV1hNPeLxVkgg94wqQ8qCEe00jkSXw7KgrAp2WzDyTplktnCsVxZPD4_dOmWdXxPG9K4WiFjIpxl9hJvzs-ufHR5aK_CMGqHzOMtz5bL42AthjRGoHyVzZ1peVi2sRGSdiaRyFT8RwSCi9Gw1dWpzrbVTO7BU4Kw-AxOOUE8W5UR00_JxaiLn8ryptLNaetkAPv22SRZ4x6n9xSAh_wN1kdS6SIIuGnA0kx_WjBtvSn5DVb0rtD_VZBJ-z1HyYkwN-Dp7jD8WRUts4csJyiit0WU3Cof4VFvA7FW4bsUEhRvw_ZVJJHXx6htT2f3_VPZgNSJnvkpw24el8b-J_4KIZ5weVGZ9AMunZ73fV8_2wQET
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9MwED-NIfFHCPFvUBhgEIgHZM12XKd7QKgCpoa1feqkvmVO7CBElXRrp2lv-w58Dz4Un4S7xCndw-Bpj0lOzsV3se98d78DeCMz6dAKNdxlWc41-hC8p2XOI1eYbrZrRWQpojsam8GB_jrtTjfgV1sLQ2mV7ZpYL9SuyumMfEfhTkchNiE-zo84dY2i6GrbQqNRi31_doou2-JD8hnl-1apvS-TTwMeugrwnHqA8zgvisjl8a4XwhojkLVIFs70vKy7NwllnVEycjU0D1kAhGbZ6-rMFlprF-G41-A6sUPOXjxdOXjomwTUS0p7iNU0gERSlQzVOXr8mm_WCupgs7YJXiisW7Nvb8Od04pC5osfdcb82r63dw_uBoOV9RsNuw8bvnwAN0YhJP8QloNhn9WtNVmSsP5shvsYa6BOPN4KCeueUSVKVTKCucaR6HJelZTFwb6XjLxhJpktHRtX5e_zn0mTIs8nZNN61xAoFvJ3Fo_g4EomfQs2S-TqCTDhyMrKVUHAOj0fZ0Y5VxTdSDurpZcd4O3cpnnAOad2G7OU_B2URdrIIg2y6MC7Ff28Qfi4lPI1iuq_RNutJNOwHCzSv8rbgVerx_gjU3TGlr46QZpIaxVrE-EQjxsNWL0K18mYTO8OvL-gEmlTLHsJK0__zcpLuDmYjIbpMBnvP4Nbig4S6uS6bdhcHp_452htLbMXtYozOLzqf-oP_AM4wA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HLA+Class+II+Allele+Analyses+Implicate+Common+Genetic+Components+in+Type+1+and+Non%E2%80%93Insulin-Treated+Type+2+Diabetes&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Jacobi%2C+Thomas&rft.au=Lucas+Massier&rft.au=Kl%C3%B6ting%2C+Nora&rft.au=Horn%2C+Katrin&rft.date=2020-03-01&rft.pub=Oxford+University+Press&rft.issn=0021-972X&rft.eissn=1945-7197&rft.volume=105&rft.issue=3&rft.spage=e245&rft.epage=e254&rft_id=info:doi/10.1210%2Fclinem%2Fdgaa027
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon