Relative Contribution of Insulin and Its Precursors to Fibrinogen and PAI-1 in a Large Population With Different States of Glucose Tolerance: The Insulin Resistance Atherosclerosis Study (IRAS)

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 19; no. 3; pp. 562 - 568
• Main Authors: Festa, Andreas, D'Agostino, Ralph, Mykkanen, Leena, Tracy, Russell P., Zaccaro, Daniel J., Hales, C. Nick, Haffner, Steven M.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.03.1999; Hagerstown, MD Lippincott
• Subjects: African Continental Ancestry Group; Arteriosclerosis - ethnology; Arteriosclerosis - metabolism; Asian Continental Ancestry Group; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diabetes Mellitus, Type 2 - metabolism; European Continental Ancestry Group; Female; Fibrinogen - metabolism; Fibrinolysis - physiology; Glucose Tolerance Test; Humans; Hyperinsulinism - ethnology; Hyperinsulinism - metabolism; Hypoglycemic Agents - blood; Insulin - blood; Insulin Resistance - physiology; Male; Medical sciences; Middle Aged; Plasminogen Activator Inhibitor 1 - blood; Proinsulin - blood; Regression Analysis; Risk Factors; Endocrinopathy; Vascular disease; Human; Plasminogen activator inhibitor 1; Target tissue resistance; Atherosclerosis; Risk factor; Fibrinogen; Cardiovascular disease; Non insulin dependent diabetes; Insulin

Hyperinsulinemia is associated with the development of coronary heart disease. However, the underlying mechanisms are still poorly understood. Hypercoagulability and impaired fibrinolysis are possible candidates linking hyperinsulinism with atherosclerotic disease, and it has been suggested that pro...