A Water Relaxation Atlas for Age‐ and Region‐Specific Metabolite Concentration Correction at 3 T

• Published in: NMR in biomedicine Vol. 38; no. 1; pp. e5300 - n/a
• Main Authors: Simegn, Gizeaddis Lamesgin, Song, Yulu, Murali‐Manohar, Saipavitra, Zöllner, Helge J., Davies‐Jenkins, Christopher W., Simicic, Dunja, Hupfeld, Kathleen E., Gudmundson, Aaron T., Muska, Emlyn, Carter, Emily, Hui, Steve C. N., Yedavalli, Vivek, Oeltzschner, Georg, Dean, Douglas C., Ceritoglu, Can, Ratnanather, J. Tilak, Porges, Eric, Edden, Richard
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2025
• Subjects: Adult; Age; Aging; Aging - metabolism; Atlases as Topic; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain mapping; brain parcels; Cerebrospinal fluid; Female; Humans; Image acquisition; Life span; Magnetic induction; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; metabolite quantification; Metabolites; Middle Aged; MRS; Reference signals; relaxation times; Relaxometry atlas; Substantia alba; Substantia grisea; Water; Water - chemistry; Water - metabolism; Workflow; Young Adult; Relaxometry atlas; relaxation times; aging; metabolite quantification; brain parcels; MRS

ABSTRACT Metabolite concentration estimates from magnetic resonance spectroscopy (MRS) are typically quantified using water referencing, correcting for relaxation‐time differences between metabolites and water. One common approach is to correct the reference signal for differential relaxation within...