Effect of one month ketoconazole treatment on GH, cortisol and ACTH release after ghrelin, GHRP-6 and GHRH administration in patients with Cushing's disease

GH responses to ghrelin, GHRP-6, and GHRH in Cushing's disease (CD) are markedly blunted. There is no data about the effect of reduction of cortisol levels with steroidogenesis inhibitors, like ketoconazole, on GH secretion in CD. ACTH levels during ketoconazole treatment are controversial. The...

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Published inArquivos brasileiros de endocrinologia e metabologia Vol. 51; no. 7; pp. 1110 - 1117
Main Authors Correa-Silva, Silvia R, Nascif, Sérgio O, Silva, Marcos R, Molica, Patrícia, Lengyel, Ana-Maria J
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01.10.2007
Subjects
Adrenocorticotropic Hormone - secretion
Adult
Case-Control Studies
Cushing Syndrome - drug therapy
Cushing Syndrome - metabolism
ENDOCRINOLOGY & METABOLISM
Female
Ghrelin - administration & dosage
Growth Hormone-Releasing Hormone - administration & dosage
Human Growth Hormone - secretion
Humans
Hydrocortisone - secretion
Hydrocortisone - urine
Ketoconazole - therapeutic use
Male
Middle Aged
Oligopeptides - administration & dosage
Peptide Hormones - administration & dosage
Radioimmunoassay
Statistics, Nonparametric
Time Factors
GH
Ghrelina
Ghrelin
Cushing’s disease
GHRH
ACTH
GHRP-6
Doença de Cushing
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Abstract GH responses to ghrelin, GHRP-6, and GHRH in Cushing's disease (CD) are markedly blunted. There is no data about the effect of reduction of cortisol levels with steroidogenesis inhibitors, like ketoconazole, on GH secretion in CD. ACTH levels during ketoconazole treatment are controversial. The aims of this study were to compare the GH response to ghrelin, GHRP-6, and GHRH, and the ACTH and cortisol responses to ghrelin and GHRP-6 before and after one month of ketoconazole treatment in 6 untreated patients with CD. Before treatment peak GH (microg/L; mean +/- SEM) after ghrelin, GHRP-6, and GHRH administration was 10.0 +/- 4.5; 3.8 +/- 1.6, and 0.6 +/- 0.2, respectively. After one month of ketoconazole there was a significant decrease in urinary cortisol values (mean reduction: 75%), but GH responses did not change (7.0 +/- 2.0; 3.1 +/- 0.8; 0.9 +/- 0.2, respectively). After treatment, there was a significant reduction in cortisol (microg/dL) responses to ghrelin (before: 30.6 +/- 5.2; after: 24.2 +/- 5.1). No significant changes in ACTH (pg/mL) responses before (ghrelin: 210.9 +/- 69.9; GHRP-6: 199.8 +/- 88.8) and after treatment (ghrelin: 159.7 +/- 40.3; GHRP-6: 227 +/- 127.2) were observed. In conclusion, after short-term ketoconazole treatment there are no changes in GH or ACTH responses, despite a major decrease of cortisol levels. A longer period of treatment might be necessary for the recovery of pituitary function.
AbstractList GH responses to ghrelin, GHRP-6, and GHRH in Cushing’s disease (CD) are markedly blunted. There is no data about the effect of reduction of cortisol levels with steroidogenesis inhibitors, like ketoconazole, on GH secretion in CD. ACTH levels during ketoconazole treatment are controversial. The aims of this study were to compare the GH response to ghrelin, GHRP-6, and GHRH, and the ACTH and cortisol responses to ghrelin and GHRP-6 before and after one month of ketoconazole treatment in 6 untreated patients with CD. Before treatment peak GH (mg/L; mean ± SEM) after ghrelin, GHRP-6, and GHRH administration was 10.0 ± 4.5; 3.8 ± 1.6, and 0.6 ± 0.2, respectively. After one month of ketoconazole there was a significant decrease in urinary cortisol values (mean reduction: 75%), but GH responses did not change (7.0 ± 2.0; 3.1 ± 0.8; 0.9 ± 0.2, respectively). After treatment, there was a significant reduction in cortisol (mg/dL) responses to ghrelin (before: 30.6 ± 5.2; after: 24.2 ± 5.1). No significant changes in ACTH (pg/mL) responses before (ghrelin: 210.9 ± 69.9; GHRP-6: 199.8 ± 88.8) and after treatment (ghrelin: 159.7 ± 40.3; GHRP-6: 227 ± 127.2) were observed. In conclusion, after short-term ketoconazole treatment there are no changes in GH or ACTH responses, despite a major decrease of cortisol levels. A longer period of treatment might be necessary for the recovery of pituitary function. Na doença de Cushing (DC), as respostas do GH à ghrelina, ao GHRP-6 e ao GHRH estão diminuídas. Não existem dados sobre o efeito da redução dos níveis de cortisol, após cetoconazol, na secreção de GH na DC. Nessa situação, os níveis de ACTH são variáveis. Os objetivos do estudo são comparar as respostas do GH à administração de ghrelina, GHRP-6 e GHRH, e de ACTH e cortisol à ghrelina e ao GHRP-6 antes e após um mês de tratamento com cetoconazol em 6 pacientes com DC não tratados. Antes do tratamento, o pico de GH (mg/L; média ± EPM) após a administração de ghrelina, GHRP-6 e GHRH foi de 10,0 ± 4,5; 3,8 ± 1,6 e 0,6 ± 0,2, respectivamente. Após um mês de cetoconazol, ocorreu diminuição significante do cortisol urinário (redução média: 75%), mas as respostas de GH permaneceram inalteradas (7,0 ± 2,0; 3,1 ± 0,8; 0,9 ± 0,2, respectivamente). Após o tratamento, houve redução da resposta de cortisol (mg/dL) à ghrelina (antes: 30,6 ± 5,2; após: 24,2 ± 5,1), mas não ocorreram mudanças nas respostas de ACTH (pg/mL) (ghrelina antes: 210,9 ± 69,9; após: 159,7 ± 40,3; GHRP-6 antes: 199,8 ± 88,8; após: 227 ± 127,2). Assim, o tratamento a curto prazo com cetoconazol não modificou as respostas de GH ou ACTH, apesar da redução do cortisol. Para a recuperação da função hipofisária deve ser necessário um período de tratamento maior.
GH responses to ghrelin, GHRP-6, and GHRH in Cushing's disease (CD) are markedly blunted. There is no data about the effect of reduction of cortisol levels with steroidogenesis inhibitors, like ketoconazole, on GH secretion in CD. ACTH levels during ketoconazole treatment are controversial. The aims of this study were to compare the GH response to ghrelin, GHRP-6, and GHRH, and the ACTH and cortisol responses to ghrelin and GHRP-6 before and after one month of ketoconazole treatment in 6 untreated patients with CD. Before treatment peak GH (microg/L; mean +/- SEM) after ghrelin, GHRP-6, and GHRH administration was 10.0 +/- 4.5; 3.8 +/- 1.6, and 0.6 +/- 0.2, respectively. After one month of ketoconazole there was a significant decrease in urinary cortisol values (mean reduction: 75%), but GH responses did not change (7.0 +/- 2.0; 3.1 +/- 0.8; 0.9 +/- 0.2, respectively). After treatment, there was a significant reduction in cortisol (microg/dL) responses to ghrelin (before: 30.6 +/- 5.2; after: 24.2 +/- 5.1). No significant changes in ACTH (pg/mL) responses before (ghrelin: 210.9 +/- 69.9; GHRP-6: 199.8 +/- 88.8) and after treatment (ghrelin: 159.7 +/- 40.3; GHRP-6: 227 +/- 127.2) were observed. In conclusion, after short-term ketoconazole treatment there are no changes in GH or ACTH responses, despite a major decrease of cortisol levels. A longer period of treatment might be necessary for the recovery of pituitary function.
GH responses to ghrelin, GHRP-6, and GHRH in Cushing’s disease (CD) are markedly blunted. There is no data about the effect of reduction of cortisol levels with steroidogenesis inhibitors, like ketoconazole, on GH secretion in CD. ACTH levels during ketoconazole treatment are controversial. The aims of this study were to compare the GH response to ghrelin, GHRP-6, and GHRH, and the ACTH and cortisol responses to ghrelin and GHRP-6 before and after one month of ketoconazole treatment in 6 untreated patients with CD. Before treatment peak GH (mg/L; mean ± SEM) after ghrelin, GHRP-6, and GHRH administration was 10.0 ± 4.5; 3.8 ± 1.6, and 0.6 ± 0.2, respectively. After one month of ketoconazole there was a significant decrease in urinary cortisol values (mean reduction: 75%), but GH responses did not change (7.0 ± 2.0; 3.1 ± 0.8; 0.9 ± 0.2, respectively). After treatment, there was a significant reduction in cortisol (mg/dL) responses to ghrelin (before: 30.6 ± 5.2; after: 24.2 ± 5.1). No significant changes in ACTH (pg/mL) responses before (ghrelin: 210.9 ± 69.9; GHRP-6: 199.8 ± 88.8) and after treatment (ghrelin: 159.7 ± 40.3; GHRP-6: 227 ± 127.2) were observed. In conclusion, after short-term ketoconazole treatment there are no changes in GH or ACTH responses, despite a major decrease of cortisol levels. A longer period of treatment might be necessary for the recovery of pituitary function.
Author Nascif, Sérgio O
Lengyel, Ana-Maria J
Correa-Silva, Silvia R
Molica, Patrícia
Silva, Marcos R
AuthorAffiliation Universidade Federal de São Paulo
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  givenname: Silvia R
  surname: Correa-Silva
  fullname: Correa-Silva, Silvia R
  email: dra.silviaregina@terra.com.br
  organization: Division of Endocrinology, Universidade Federal de São Paulo, SP. dra.silviaregina@terra.com.br
– sequence: 2
  givenname: Sérgio O
  surname: Nascif
  fullname: Nascif, Sérgio O
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  givenname: Marcos R
  surname: Silva
  fullname: Silva, Marcos R
– sequence: 4
  givenname: Patrícia
  surname: Molica
  fullname: Molica, Patrícia
– sequence: 5
  givenname: Ana-Maria J
  surname: Lengyel
  fullname: Lengyel, Ana-Maria J
BackLink https://www.ncbi.nlm.nih.gov/pubmed/18157387$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/0024-3205(88)90427-4
10.1046/j.1365-2265.2003.01922.x
10.1210/jcem-63-6-1365
10.1111/j.1365-2265.1990.tb03890.x
10.1210/jcem.85.12.7167
10.1038/45230
10.1210/jcem-53-1-165
10.1677/joe.0.1080037
10.1111/j.1365-2265.1993.tb00521.x
10.1210/jcem.87.6.8739
10.1111/j.1365-2265.1987.tb01189.x
10.1016/0960-0760(94)90267-4
10.1210/endo-125-2-699
10.1111/j.1365-2265.1987.tb01174.x
10.1210/jcem-61-4-718
10.1159/000067586
10.1111/j.1440-1681.1991.tb01492.x
10.1046/j.1365-2265.1999.00738.x
10.1385/ENDO:14:1:021
10.1210/jc.2003-030211
10.1046/j.1365-2265.2004.01976.x
10.1007/s11102-006-9149-8
10.1124/jpet.102.034827
10.1046/j.1365-2265.1998.00363.x
10.1016/S0140-6736(85)91482-5
10.1530/eje.1.02003
10.1007/BF03349543
10.1111/j.1365-2265.1994.tb01831.x
10.1126/science.273.5277.974
10.1046/j.1365-2265.1997.1981008.x
10.1038/sj.npp.1300044
10.1210/jcem.84.7.5811
10.1007/BF03345162
10.1210/jcem-44-1-218
10.1210/endo.142.6.8184
10.1111/j.1365-2265.1991.tb03547.x
10.1530/acta.0.1210185
10.1016/S0196-9781(97)00016-8
10.1007/BF03350926
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DocumentTitleAlternate Efeito do tratamento com ketoconazole por um mês na liberação de GH, cortisol e ACHT após administração de GHrelin, GHRP-6 e GHRH em pacientes com síndrome de cushing
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Issue 7
Keywords GH
Ghrelina
Ghrelin
Cushing’s disease
GHRH
ACTH
GHRP-6
Doença de Cushing
Language English
Portuguese
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References Arvat E (ref7) 2001; 86
Terzolo M (ref35) 1988; 11
Oliveira JH (ref40) 2003; 26
Tyrrell JB (ref21) 1977; 44
Leal-Cerro A (ref17) 1998; 48
Loli P (ref32) 1986; 63
Kojima M (ref3) 1999; 402
Popovic V (ref8) 1995; 80
Korbonits M (ref19) 1999; 84
Leal-Cerro A (ref16) 1993; 38
Tannenbaum GS (ref37) 2001; 14
Burrin JM (ref43) 1986; 108
Deuschle M (ref41) 2003; 28
Howard AD (ref1) 1996; 273
Leal-Cerro A (ref20) 1997; 82
Mortimer RH (ref42) 1991; 18
Correa-Silva SR (ref10) 2006; 9
Hotta M (ref11) 1998; 42
Sonino N (ref29) 1991; 35
Veldman RG (ref26) 2000; 85
Hughes NR (ref25) 1999; 51
Arvat E (ref2) 1997; 18
Leal-Cerro A (ref14) 2002; 76
Giordano R (ref15) 2005; 153
Whitehead HM (ref39) 1990; 13
Leal-Cerro A (ref12) 1994; 41
McCance DR (ref33) 1987; 27
Boscaro M (ref34) 1987; 27
Burke CW (ref23) 1990; 33
Petersenn S (ref36) 2001; 142
Angeli A (ref30) 1985; 1
Korbonits M (ref18) 1998; 83
Kuwayama A (ref22) 1981; 53
Engelhardt D (ref28) 1994; 49
Borges MH (ref13) 1997; 46
Takaya K (ref6) 2000; 85
Magiakou MA (ref24) 1994; 78
Popovic V (ref9) 2003; 88
Jimenez Reina L (ref45) 1989; 121
Stalla GK (ref44) 1989; 125
Tzanela M (ref27) 2004; 60
Carroll PV (ref38) 2004; 60
Banks WA (ref5) 2002; 302
Gnanapavan S (ref4) 2002; 87
Sonino N (ref31) 1985; 61
Terzolo, M; Panarelli, M; Piovesan, A; Torta, M; Paccotti, P; Angeli, A 1988; 11
Mortimer, RH; Cannell, GR; Thew, CM; Galligan, JP 1991; 18
Kojima, M; Hosoda, H; Date, Y; Nakazato, M; Matsuo, H; Kangawa, K 1999; 402
Sonino, N; Boscaro, M; Paoletta, A; Mantero, F 1991; 35
Popovic, V; Damjanovic, S; Micic, D; Djurovic, M; Dieguez, C; Casanueva, FF 1995; 80
Leal-Cerro, A; Torres, E; Soto, A; Dios, E; Deghenghi, R; Arvat, E 2002; 76
Correa-Silva, SR; Nascif, S; Lengyel, AM 2006; 9
Leal-Cerro, A; Jimenez, LM; Astorga, R; Fernandez-Lopez, I; Dieguez, C; Casanueva, FF 1997; 82
McCance, DR; Hadden, DR; Kennedy, L; Sheridan, B; Atkinson, AB 1987; 27
Hotta, M; Shibasaki, T; Masuda, A; Imaki, T; Sugino, N; Demura, H 1998; 42
Veldman, RG; Frolich, M; Pincus, SM; Veldhuis, JD; Roelfsema, F 2000; 85
Gnanapavan, S; Kola, B; Bustin, SA; Morris, DG; McGee, P; Fairclough, P 2002; 87
Tannenbaum, GS; Bowers, CY 2001; 14
Deuschle, M; Lecei, O; Stalla, GK; Landgraf, R; Hamann, B; Lederbogen, F 2003; 28
Tyrrell, JB; Wiener-Kronish, J; Lorenzi, M; Brooks, RM; Forsham, PH 1977; 44
Hughes, NR; Lissett, CA; Shalet, SM 1999; 51
Takaya, K; Ariyasu, H; Kanamoto, N; Iwakura, H; Yoshimoto, A; Harada, M 2000; 85
Arvat, E; Maccario, M; Di Vito, L; Broglio, F; Benso, A; Gottero, C 2001; 86
Whitehead, HM; McKnight, JA; Sheridan, B; Kennedy, AL; Hadden, DR; Atkinson, AB 1990; 13
Howard, AD; Feighner, SD; Cully, DF; Arena, JP; Liberator, PA; Rosenblum, CI 1996; 273
Kuwayama, A; Kageyama, N; Nakane, T; Watanabe, M; Kanie, N 1981; 53
Carroll, PV; Monson, JP; Grossman, AB; Besser, GM; Plowman, PN; Afshar, F 2004; 60
Arvat, E; di Vito, L; Maccagno, B; Broglio, F; Boghen, MF; Deghenghi, R 1997; 18
Burrin, JM; Yeo, TH; Ashby, MJ; Bloom, SR 1986; 108
Borges, MH; DiNinno, FB; Lengyel, AM 1997; 46
Engelhardt, D; Weber, MM 1994; 49
Burke, CW; Adams, CB; Esiri, MM; Morris, C; Bevan, JS 1990; 33
Stalla, GK; Stalla, J; von Werder, K; Muller, OA; Gerzer, R; Hollt, V 1989; 125
Sonino, N; Boscaro, M; Merola, G; Mantero, F 1985; 61
Magiakou, MA; Mastorakos, G; Gomez, MT; Rose, SR; Chrousos, GP 1994; 78
Leal-Cerro, A; Pumar, A; Villamil, F; Astorga, R; Dieguez, C; Casanueva, FF 1993; 38
Banks, WA; Tschop, M; Robinson, SM; Heiman, ML 2002; 302
Loli, P; Berselli, ME; Tagliaferri, M 1986; 63
Leal-Cerro, A; Pumar, A; Garcia-Garcia, E; Dieguez, C; Casanueva, FF 1994; 41
Boscaro, M; Sonino, N; Rampazzo, A; Mantero, F 1987; 27
Angeli, A; Frairia, R 1985; 1
Korbonits, M; Jacobs, RA; Aylwin, SJ; Burrin, JM; Dahia, PL; Monson, JP 1998; 83
Petersenn, S; Rasch, AC; Penshorn, M; Beil, FU; Schulte, HM 2001; 142
Tzanela, M; Karavitaki, N; Stylianidou, C; Tsagarakis, S; Thalassinos, NC 2004; 60
Jimenez Reina, L; Leal-Cerro, A; Garcia, J; Garcia-Luna, PP; Astorga, R; Bernal, G 1989; 121
Leal-Cerro, A; Venegas, E; Garcia-Pesquera, F; Jimenez, LM; Astorga, R; Casanueva, FF 1998; 48
Korbonits, M; Kaltsas, G; Perry, LA; Putignano, P; Grossman, AB; Besser, GM 1999; 84
Oliveira, JH; Vieira, JG; Abucham, J; Lengyel, AM 2003; 26
Popovic, V; Miljic, D; Micic, D; Damjanovic, S; Arvat, E; Ghigo, E 2003; 88
Giordano, R; Picu, A; Pagotto, U; De Iasio, R; Bonelli, L; Prodam, F 2005; 153
References_xml – volume: 42
  start-page: 979
  issn: 0024-3205
  year: 1998
  ident: ref11
  article-title: Effect of human growth hormone-releasing hormone on GH secretion in Cushing’s syndrome and non-endocrine disease patients treated with glucocorticoids
  publication-title: Life Sci
  doi: 10.1016/0024-3205(88)90427-4
  contributor:
    fullname: Hotta M
– volume: 60
  start-page: 169
  year: 2004
  ident: ref38
  article-title: Successful treatment of childhood-onset Cushing’s disease is associated with persistent reduction in growth hormone secretion
  publication-title: Clin Endocrinol
  doi: 10.1046/j.1365-2265.2003.01922.x
  contributor:
    fullname: Carroll PV
– volume: 63
  start-page: 1365
  issn: 0021-972X
  year: 1986
  ident: ref32
  article-title: Use of ketoconazole in the treatment of Cushing’s syndrome
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem-63-6-1365
  contributor:
    fullname: Loli P
– volume: 33
  start-page: 525
  year: 1990
  ident: ref23
  article-title: Transsphenoidal surgery for Cushing’s disease: does what is removed determine the endocrine outcome?
  publication-title: Clin Endocrinol
  doi: 10.1111/j.1365-2265.1990.tb03890.x
  contributor:
    fullname: Burke CW
– volume: 85
  start-page: 4908
  issn: 0021-972X
  year: 2000
  ident: ref6
  article-title: Ghrelin strongly stimulates growth hormone release in humans
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem.85.12.7167
  contributor:
    fullname: Takaya K
– volume: 402
  start-page: 656
  issn: 0028-0836
  year: 1999
  ident: ref3
  article-title: Ghrelin is a growth hormone-releasing hormone acylated peptide from stomach
  publication-title: Nature
  doi: 10.1038/45230
  contributor:
    fullname: Kojima M
– volume: 53
  start-page: 165
  issn: 0021-972X
  year: 1981
  ident: ref22
  article-title: Anterior pituitary function after transsphenoidal selective adenomectomy in patients with Cushing’s disease
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem-53-1-165
  contributor:
    fullname: Kuwayama A
– volume: 108
  start-page: 37
  issn: 0022-0795
  year: 1986
  ident: ref43
  article-title: Effect of ketoconazole on adrenocorticotrophic hormone secretion in vitro and in vivo
  publication-title: J Endocrinol
  doi: 10.1677/joe.0.1080037
  contributor:
    fullname: Burrin JM
– volume: 85
  start-page: 4039
  issn: 0021-972X
  year: 2000
  ident: ref26
  article-title: Apparently complete restoration of normal daily adrenocorticotropin, cortisol, growth hormone, and prolactin secretory dynamics in adults with Cushing’s disease after clinically successful transsphenoidal adenomectomy
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Veldman RG
– volume: 38
  start-page: 399
  year: 1993
  ident: ref16
  article-title: Growth hormone releasing hormone priming increases growth hormone secretion in patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  doi: 10.1111/j.1365-2265.1993.tb00521.x
  contributor:
    fullname: Leal-Cerro A
– volume: 87
  start-page: 2988
  issn: 0021-972X
  year: 2002
  ident: ref4
  article-title: The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem.87.6.8739
  contributor:
    fullname: Gnanapavan S
– volume: 80
  start-page: 942
  issn: 0021-972X
  year: 1995
  ident: ref8
  article-title: Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Popovic V
– volume: 27
  start-page: 593
  year: 1987
  ident: ref33
  article-title: Clinical experience with ketoconazole as a therapy for patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  doi: 10.1111/j.1365-2265.1987.tb01189.x
  contributor:
    fullname: McCance DR
– volume: 49
  start-page: 261
  issn: 0960-0760
  year: 1994
  ident: ref28
  article-title: Therapy of Cushing’s syndrome with steroid biosynthesis inhibitors
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/0960-0760(94)90267-4
  contributor:
    fullname: Engelhardt D
– volume: 125
  start-page: 699
  issn: 0013-7227
  year: 1989
  ident: ref44
  article-title: Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme
  publication-title: Endocrinology
  doi: 10.1210/endo-125-2-699
  contributor:
    fullname: Stalla GK
– volume: 27
  start-page: 461
  year: 1987
  ident: ref34
  article-title: Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing’s disease before and after ketoconazole treatment
  publication-title: Clin Endocrinol
  doi: 10.1111/j.1365-2265.1987.tb01174.x
  contributor:
    fullname: Boscaro M
– volume: 61
  start-page: 718
  issn: 0021-972X
  year: 1985
  ident: ref31
  article-title: Prolonged treatment of Cushing’s disease by ketoconazole
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem-61-4-718
  contributor:
    fullname: Sonino N
– volume: 78
  start-page: 131
  issn: 0021-972X
  year: 1994
  ident: ref24
  article-title: Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing’s disease before and after surgical cure
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Magiakou MA
– volume: 76
  start-page: 390
  issn: 0028-3835
  year: 2002
  ident: ref14
  article-title: Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses
  publication-title: Neuroendocrinology
  doi: 10.1159/000067586
  contributor:
    fullname: Leal-Cerro A
– volume: 18
  start-page: 563
  issn: 0305-1870
  year: 1991
  ident: ref42
  article-title: Ketoconazole and plasma and urine steroid levels in Cushing’s disease
  publication-title: Clin Exp Pharmacol Physiol
  doi: 10.1111/j.1440-1681.1991.tb01492.x
  contributor:
    fullname: Mortimer RH
– volume: 51
  start-page: 61
  year: 1999
  ident: ref25
  article-title: Growth hormone status following treatment for Cushing’s syndrome
  publication-title: Clin Endocrinol
  doi: 10.1046/j.1365-2265.1999.00738.x
  contributor:
    fullname: Hughes NR
– volume: 14
  start-page: 21
  issn: 0969-711X
  year: 2001
  ident: ref37
  article-title: Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin
  publication-title: Endocrine
  doi: 10.1385/ENDO:14:1:021
  contributor:
    fullname: Tannenbaum GS
– volume: 83
  start-page: 3624
  year: 1998
  ident: ref18
  article-title: Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors
  publication-title: J Clin Endocrinol Meta
  contributor:
    fullname: Korbonits M
– volume: 88
  start-page: 3450
  issn: 0021-972X
  year: 2003
  ident: ref9
  article-title: Ghrelin main action on the regulation of growth hormone release is exerted at hypothalamic level
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2003-030211
  contributor:
    fullname: Popovic V
– volume: 60
  start-page: 309
  year: 2004
  ident: ref27
  article-title: Assessment of GH reserve before and after successful treatment of adult patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  doi: 10.1046/j.1365-2265.2004.01976.x
  contributor:
    fullname: Tzanela M
– volume: 9
  start-page: 101
  issn: 1386-341X
  issue: 2
  year: 2006
  ident: ref10
  article-title: Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing’s disease: Comparison with GH-releasing peptide-6 (GHRP-6) and GHRH
  publication-title: Pituitary
  doi: 10.1007/s11102-006-9149-8
  contributor:
    fullname: Correa-Silva SR
– volume: 302
  start-page: 822
  issn: 0022-3565
  year: 2002
  ident: ref5
  article-title: Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.102.034827
  contributor:
    fullname: Banks WA
– volume: 48
  start-page: 117
  year: 1998
  ident: ref17
  article-title: Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary restriction in patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  doi: 10.1046/j.1365-2265.1998.00363.x
  contributor:
    fullname: Leal-Cerro A
– volume: 82
  start-page: 3165
  issn: 0021-972X
  year: 1997
  ident: ref20
  article-title: Acute pharmacological reduction of plasma free fatty acids enhances the growth hormone (GH)-releasing hormone-mediated GH secretion in patients with Cushing’s syndrome
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Leal-Cerro A
– volume: 1
  start-page: 821
  issn: 0099-5355
  year: 1985
  ident: ref30
  article-title: Ketoconazole therapy in Cushing’s disease
  publication-title: Lancet
  doi: 10.1016/S0140-6736(85)91482-5
  contributor:
    fullname: Angeli A
– volume: 153
  start-page: 535
  issn: 0804-4643
  year: 2005
  ident: ref15
  article-title: The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing’s disease
  publication-title: Eur J Endocrinol
  doi: 10.1530/eje.1.02003
  contributor:
    fullname: Giordano R
– volume: 13
  start-page: 217
  issn: 0391-4097
  year: 1990
  ident: ref39
  article-title: The growth hormone response to growth hormone releasing hormone in patients previously treated with bilateral adrenalectomy alone for Cushing’s disease
  publication-title: J Endocrinol Invest
  doi: 10.1007/BF03349543
  contributor:
    fullname: Whitehead HM
– volume: 41
  start-page: 649
  year: 1994
  ident: ref12
  article-title: Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  doi: 10.1111/j.1365-2265.1994.tb01831.x
  contributor:
    fullname: Leal-Cerro A
– volume: 273
  start-page: 974
  issn: 0036-8075
  year: 1996
  ident: ref1
  article-title: A receptor in pituitary and hypothalamus that functions in growth hormone release
  publication-title: Science
  doi: 10.1126/science.273.5277.974
  contributor:
    fullname: Howard AD
– volume: 86
  start-page: 1169
  issn: 0021-972X
  year: 2001
  ident: ref7
  article-title: Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Arvat E
– volume: 46
  start-page: 713
  year: 1997
  ident: ref13
  article-title: Different effects of growth hormone releasing peptide (GHRP-6) and GH-releasing hormone on GH release in endogenous and exogenous hypercortisolism
  publication-title: Clin Endocrinol
  doi: 10.1046/j.1365-2265.1997.1981008.x
  contributor:
    fullname: Borges MH
– volume: 28
  start-page: 379
  issn: 0893-133X
  year: 2003
  ident: ref41
  article-title: Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy
  publication-title: Neuropsychopharmacology
  doi: 10.1038/sj.npp.1300044
  contributor:
    fullname: Deuschle M
– volume: 84
  start-page: 2489
  issn: 0021-972X
  year: 1999
  ident: ref19
  article-title: The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem.84.7.5811
  contributor:
    fullname: Korbonits M
– volume: 26
  start-page: 230
  issn: 0391-4097
  year: 2003
  ident: ref40
  article-title: GHRP-6 is able to stimulate cortisol and ACTH release in patients with Cushing’s disease: comparison with DDAVP
  publication-title: J Endocrinol Invest
  doi: 10.1007/BF03345162
  contributor:
    fullname: Oliveira JH
– volume: 44
  start-page: 218
  issn: 0021-972X
  year: 1977
  ident: ref21
  article-title: Cushing’s disease: growth hormone response to hypoglycemia after correction of hypercortisolism
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem-44-1-218
  contributor:
    fullname: Tyrrell JB
– volume: 142
  start-page: 2649
  issn: 0013-7227
  year: 2001
  ident: ref36
  article-title: Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor
  publication-title: Endocrinology
  doi: 10.1210/endo.142.6.8184
  contributor:
    fullname: Petersenn S
– volume: 35
  start-page: 347
  year: 1991
  ident: ref29
  article-title: Ziliotto D. Ketoconazole treatment in Cushing’s syndrome: experience in 34 patients
  publication-title: Clin Endocrinol
  doi: 10.1111/j.1365-2265.1991.tb03547.x
  contributor:
    fullname: Sonino N
– volume: 121
  start-page: 185
  issn: 0001-5598
  year: 1989
  ident: ref45
  article-title: In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson’s syndrome
  publication-title: Acta Endocrinol
  doi: 10.1530/acta.0.1210185
  contributor:
    fullname: Jimenez Reina L
– volume: 18
  start-page: 885
  issn: 0079-0753
  year: 1997
  ident: ref2
  article-title: Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man: Comparison with the effects of GHRH, TRH and hCRH
  publication-title: Peptides
  doi: 10.1016/S0196-9781(97)00016-8
  contributor:
    fullname: Arvat E
– volume: 11
  start-page: 717
  issn: 0391-4097
  year: 1988
  ident: ref35
  article-title: Ketoconazole treatment in Cushing’s disease: Effect on the circadian profile of plasma ACTH and cortisol
  publication-title: J Endocrinol Invest
  doi: 10.1007/BF03350926
  contributor:
    fullname: Terzolo M
– volume: 60
  start-page: 309
  year: 2004
  end-page: 14
  article-title: Assessment of GH reserve before and after successful treatment of adult patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  contributor:
    fullname: Tzanela, M; Karavitaki, N; Stylianidou, C; Tsagarakis, S; Thalassinos, NC
– volume: 1
  start-page: 821
  year: 1985
  article-title: Ketoconazole therapy in Cushing’s disease
  publication-title: Lancet
  contributor:
    fullname: Angeli, A; Frairia, R
– volume: 35
  start-page: 347
  year: 1991
  end-page: 52
  article-title: Ziliotto D. Ketoconazole treatment in Cushing’s syndrome: experience in 34 patients
  publication-title: Clin Endocrinol
  contributor:
    fullname: Sonino, N; Boscaro, M; Paoletta, A; Mantero, F
– volume: 48
  start-page: 117
  year: 1998
  end-page: 21
  article-title: Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary restriction in patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  contributor:
    fullname: Leal-Cerro, A; Venegas, E; Garcia-Pesquera, F; Jimenez, LM; Astorga, R; Casanueva, FF
– volume: 76
  start-page: 390
  year: 2002
  end-page: 6
  article-title: Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses
  publication-title: Neuroendocrinology
  contributor:
    fullname: Leal-Cerro, A; Torres, E; Soto, A; Dios, E; Deghenghi, R; Arvat, E
– volume: 142
  start-page: 2649
  year: 2001
  end-page: 59
  article-title: Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor
  publication-title: Endocrinology
  contributor:
    fullname: Petersenn, S; Rasch, AC; Penshorn, M; Beil, FU; Schulte, HM
– volume: 46
  start-page: 713
  year: 1997
  end-page: 8
  article-title: Different effects of growth hormone releasing peptide (GHRP-6) and GH-releasing hormone on GH release in endogenous and exogenous hypercortisolism
  publication-title: Clin Endocrinol
  contributor:
    fullname: Borges, MH; DiNinno, FB; Lengyel, AM
– volume: 49
  start-page: 261
  year: 1994
  end-page: 7
  article-title: Therapy of Cushing’s syndrome with steroid biosynthesis inhibitors
  publication-title: J Steroid Biochem Mol Biol
  contributor:
    fullname: Engelhardt, D; Weber, MM
– volume: 88
  start-page: 3450
  year: 2003
  end-page: 3
  article-title: Ghrelin main action on the regulation of growth hormone release is exerted at hypothalamic level
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Popovic, V; Miljic, D; Micic, D; Damjanovic, S; Arvat, E; Ghigo, E
– volume: 61
  start-page: 718
  year: 1985
  end-page: 22
  article-title: Prolonged treatment of Cushing’s disease by ketoconazole
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Sonino, N; Boscaro, M; Merola, G; Mantero, F
– volume: 121
  start-page: 185
  year: 1989
  end-page: 90
  article-title: In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson’s syndrome
  publication-title: Acta Endocrinol
  contributor:
    fullname: Jimenez Reina, L; Leal-Cerro, A; Garcia, J; Garcia-Luna, PP; Astorga, R; Bernal, G
– volume: 402
  start-page: 656
  year: 1999
  end-page: 60
  article-title: Ghrelin is a growth hormone-releasing hormone acylated peptide from stomach
  publication-title: Nature
  contributor:
    fullname: Kojima, M; Hosoda, H; Date, Y; Nakazato, M; Matsuo, H; Kangawa, K
– volume: 9
  start-page: 101
  issue: 2
  year: 2006
  end-page: 7
  article-title: Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing’s disease: Comparison with GH-releasing peptide-6 (GHRP-6) and GHRH
  publication-title: Pituitary
  contributor:
    fullname: Correa-Silva, SR; Nascif, S; Lengyel, AM
– volume: 85
  start-page: 4039
  year: 2000
  end-page: 46
  article-title: Apparently complete restoration of normal daily adrenocorticotropin, cortisol, growth hormone, and prolactin secretory dynamics in adults with Cushing’s disease after clinically successful transsphenoidal adenomectomy
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Veldman, RG; Frolich, M; Pincus, SM; Veldhuis, JD; Roelfsema, F
– volume: 86
  start-page: 1169
  year: 2001
  end-page: 74
  article-title: Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Arvat, E; Maccario, M; Di Vito, L; Broglio, F; Benso, A; Gottero, C
– volume: 83
  start-page: 3624
  year: 1998
  end-page: 30
  article-title: Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors
  publication-title: J Clin Endocrinol Meta
  contributor:
    fullname: Korbonits, M; Jacobs, RA; Aylwin, SJ; Burrin, JM; Dahia, PL; Monson, JP
– volume: 33
  start-page: 525
  year: 1990
  end-page: 37
  article-title: Transsphenoidal surgery for Cushing’s disease: does what is removed determine the endocrine outcome?
  publication-title: Clin Endocrinol
  contributor:
    fullname: Burke, CW; Adams, CB; Esiri, MM; Morris, C; Bevan, JS
– volume: 14
  start-page: 21
  year: 2001
  end-page: 7
  article-title: Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin
  publication-title: Endocrine
  contributor:
    fullname: Tannenbaum, GS; Bowers, CY
– volume: 84
  start-page: 2489
  year: 1999
  end-page: 95
  article-title: The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Korbonits, M; Kaltsas, G; Perry, LA; Putignano, P; Grossman, AB; Besser, GM
– volume: 63
  start-page: 1365
  year: 1986
  end-page: 71
  article-title: Use of ketoconazole in the treatment of Cushing’s syndrome
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Loli, P; Berselli, ME; Tagliaferri, M
– volume: 27
  start-page: 461
  year: 1987
  end-page: 7
  article-title: Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing’s disease before and after ketoconazole treatment
  publication-title: Clin Endocrinol
  contributor:
    fullname: Boscaro, M; Sonino, N; Rampazzo, A; Mantero, F
– volume: 13
  start-page: 217
  year: 1990
  end-page: 20
  article-title: The growth hormone response to growth hormone releasing hormone in patients previously treated with bilateral adrenalectomy alone for Cushing’s disease
  publication-title: J Endocrinol Invest
  contributor:
    fullname: Whitehead, HM; McKnight, JA; Sheridan, B; Kennedy, AL; Hadden, DR; Atkinson, AB
– volume: 153
  start-page: 535
  year: 2005
  end-page: 43
  article-title: The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing’s disease
  publication-title: Eur J Endocrinol
  contributor:
    fullname: Giordano, R; Picu, A; Pagotto, U; De Iasio, R; Bonelli, L; Prodam, F
– volume: 273
  start-page: 974
  year: 1996
  end-page: 7
  article-title: A receptor in pituitary and hypothalamus that functions in growth hormone release
  publication-title: Science
  contributor:
    fullname: Howard, AD; Feighner, SD; Cully, DF; Arena, JP; Liberator, PA; Rosenblum, CI
– volume: 125
  start-page: 699
  year: 1989
  end-page: 706
  article-title: Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme
  publication-title: Endocrinology
  contributor:
    fullname: Stalla, GK; Stalla, J; von Werder, K; Muller, OA; Gerzer, R; Hollt, V
– volume: 87
  start-page: 2988
  year: 2002
  end-page: 91
  article-title: The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Gnanapavan, S; Kola, B; Bustin, SA; Morris, DG; McGee, P; Fairclough, P
– volume: 60
  start-page: 169
  year: 2004
  end-page: 74
  article-title: Successful treatment of childhood-onset Cushing’s disease is associated with persistent reduction in growth hormone secretion
  publication-title: Clin Endocrinol
  contributor:
    fullname: Carroll, PV; Monson, JP; Grossman, AB; Besser, GM; Plowman, PN; Afshar, F
– volume: 44
  start-page: 218
  year: 1977
  end-page: 21
  article-title: Cushing’s disease: growth hormone response to hypoglycemia after correction of hypercortisolism
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Tyrrell, JB; Wiener-Kronish, J; Lorenzi, M; Brooks, RM; Forsham, PH
– volume: 26
  start-page: 230
  year: 2003
  end-page: 5
  article-title: GHRP-6 is able to stimulate cortisol and ACTH release in patients with Cushing’s disease: comparison with DDAVP
  publication-title: J Endocrinol Invest
  contributor:
    fullname: Oliveira, JH; Vieira, JG; Abucham, J; Lengyel, AM
– volume: 82
  start-page: 3165
  year: 1997
  end-page: 8
  article-title: Acute pharmacological reduction of plasma free fatty acids enhances the growth hormone (GH)-releasing hormone-mediated GH secretion in patients with Cushing’s syndrome
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Leal-Cerro, A; Jimenez, LM; Astorga, R; Fernandez-Lopez, I; Dieguez, C; Casanueva, FF
– volume: 28
  start-page: 379
  year: 2003
  end-page: 83
  article-title: Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy
  publication-title: Neuropsychopharmacology
  contributor:
    fullname: Deuschle, M; Lecei, O; Stalla, GK; Landgraf, R; Hamann, B; Lederbogen, F
– volume: 53
  start-page: 165
  year: 1981
  end-page: 73
  article-title: Anterior pituitary function after transsphenoidal selective adenomectomy in patients with Cushing’s disease
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Kuwayama, A; Kageyama, N; Nakane, T; Watanabe, M; Kanie, N
– volume: 27
  start-page: 593
  year: 1987
  end-page: 9
  article-title: Clinical experience with ketoconazole as a therapy for patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  contributor:
    fullname: McCance, DR; Hadden, DR; Kennedy, L; Sheridan, B; Atkinson, AB
– volume: 42
  start-page: 979
  year: 1998
  end-page: 84
  article-title: Effect of human growth hormone-releasing hormone on GH secretion in Cushing’s syndrome and non-endocrine disease patients treated with glucocorticoids
  publication-title: Life Sci
  contributor:
    fullname: Hotta, M; Shibasaki, T; Masuda, A; Imaki, T; Sugino, N; Demura, H
– volume: 41
  start-page: 649
  year: 1994
  end-page: 54
  article-title: Inhibition of growth hormone release after the combined administration of GHRH and GHRP-6 in patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  contributor:
    fullname: Leal-Cerro, A; Pumar, A; Garcia-Garcia, E; Dieguez, C; Casanueva, FF
– volume: 51
  start-page: 61
  year: 1999
  end-page: 6
  article-title: Growth hormone status following treatment for Cushing’s syndrome
  publication-title: Clin Endocrinol
  contributor:
    fullname: Hughes, NR; Lissett, CA; Shalet, SM
– volume: 80
  start-page: 942
  year: 1995
  end-page: 7
  article-title: Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection: evidence that GHRP-6 main action is exerted at the hypothalamic level
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Popovic, V; Damjanovic, S; Micic, D; Djurovic, M; Dieguez, C; Casanueva, FF
– volume: 38
  start-page: 399
  year: 1993
  end-page: 403
  article-title: Growth hormone releasing hormone priming increases growth hormone secretion in patients with Cushing’s syndrome
  publication-title: Clin Endocrinol
  contributor:
    fullname: Leal-Cerro, A; Pumar, A; Villamil, F; Astorga, R; Dieguez, C; Casanueva, FF
– volume: 108
  start-page: 37
  year: 1986
  end-page: 41
  article-title: Effect of ketoconazole on adrenocorticotrophic hormone secretion in vitro and in vivo
  publication-title: J Endocrinol
  contributor:
    fullname: Burrin, JM; Yeo, TH; Ashby, MJ; Bloom, SR
– volume: 302
  start-page: 822
  year: 2002
  end-page: 7
  article-title: Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure
  publication-title: J Pharmacol Exp Ther
  contributor:
    fullname: Banks, WA; Tschop, M; Robinson, SM; Heiman, ML
– volume: 18
  start-page: 885
  year: 1997
  end-page: 91
  article-title: Effects of GHRP-2 and hexarelin, two synthetic GH-releasing peptides, on GH, prolactin, ACTH and cortisol levels in man: Comparison with the effects of GHRH, TRH and hCRH
  publication-title: Peptides
  contributor:
    fullname: Arvat, E; di Vito, L; Maccagno, B; Broglio, F; Boghen, MF; Deghenghi, R
– volume: 18
  start-page: 563
  year: 1991
  end-page: 9
  article-title: Ketoconazole and plasma and urine steroid levels in Cushing’s disease
  publication-title: Clin Exp Pharmacol Physiol
  contributor:
    fullname: Mortimer, RH; Cannell, GR; Thew, CM; Galligan, JP
– volume: 78
  start-page: 131
  year: 1994
  end-page: 7
  article-title: Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing’s disease before and after surgical cure
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Magiakou, MA; Mastorakos, G; Gomez, MT; Rose, SR; Chrousos, GP
– volume: 11
  start-page: 717
  year: 1988
  end-page: 21
  article-title: Ketoconazole treatment in Cushing’s disease: Effect on the circadian profile of plasma ACTH and cortisol
  publication-title: J Endocrinol Invest
  contributor:
    fullname: Terzolo, M; Panarelli, M; Piovesan, A; Torta, M; Paccotti, P; Angeli, A
– volume: 85
  start-page: 4908
  year: 2000
  end-page: 11
  article-title: Ghrelin strongly stimulates growth hormone release in humans
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Takaya, K; Ariyasu, H; Kanamoto, N; Iwakura, H; Yoshimoto, A; Harada, M
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Snippet GH responses to ghrelin, GHRP-6, and GHRH in Cushing's disease (CD) are markedly blunted. There is no data about the effect of reduction of cortisol levels...
GH responses to ghrelin, GHRP-6, and GHRH in Cushing’s disease (CD) are markedly blunted. There is no data about the effect of reduction of cortisol levels...
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SubjectTerms Adrenocorticotropic Hormone - secretion
Adult
Case-Control Studies
Cushing Syndrome - drug therapy
Cushing Syndrome - metabolism
ENDOCRINOLOGY & METABOLISM
Female
Ghrelin - administration & dosage
Growth Hormone-Releasing Hormone - administration & dosage
Human Growth Hormone - secretion
Humans
Hydrocortisone - secretion
Hydrocortisone - urine
Ketoconazole - therapeutic use
Male
Middle Aged
Oligopeptides - administration & dosage
Peptide Hormones - administration & dosage
Radioimmunoassay
Statistics, Nonparametric
Time Factors
Title Effect of one month ketoconazole treatment on GH, cortisol and ACTH release after ghrelin, GHRP-6 and GHRH administration in patients with Cushing's disease
URI https://www.ncbi.nlm.nih.gov/pubmed/18157387
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Volume 51
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