Age-related decline in cardiac autonomic function is not attenuated with increased physical activity
Age and physical inactivity are important risk factors for cardiovascular mortality. Heart rate response to exercise (HRRE) and heart rate recovery (HRR), measures of cardiac autonomic function, are strong predictors of mortality. The present study defined the effect of age and physical activity on...
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| Published in | Oncotarget Vol. 7; no. 47; pp. 76390 - 76397 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Impact Journals LLC
22.11.2016
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| Online Access | Get full text |
| ISSN | 1949-2553 1949-2553 |
| DOI | 10.18632/oncotarget.12403 |
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| Abstract | Age and physical inactivity are important risk factors for cardiovascular mortality. Heart rate response to exercise (HRRE) and heart rate recovery (HRR), measures of cardiac autonomic function, are strong predictors of mortality. The present study defined the effect of age and physical activity on HRRE and HRR. Healthy women (N=72) grouped according to age (young, 20-30 years; middle, 40-50 years; and older, 65-81 years) and daily physical activity (low active <7500, high active >12,500 steps/day) performed a maximal cardiopulmonary exercise test. The HRRE was defined as an increase in heart rate from rest to 1, 3 and 5 minutes of exercise and at 1/3 of total exercise time, and HRR as the difference in heart rate between peak exercise and 1, 2, and 3 minutes later. Age was associated with a significant decline in HRRE at 1 min and 1/3 of exercise time (r=-0.27, p=0.04, and r=-0.39, p=0.02) and HRR at 2 min and 3 min (r=-0.35, p=0.01, and r=-0.31, p=0.02). There was no significant difference in HRRE and HRR between high and low-active middle-age and older women (p>0.05). Increased level of habitual physical activity level appears to have a limited effect on age-related decline in cardiac autonomic function in women. |
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| AbstractList | Age and physical inactivity are important risk factors for cardiovascular mortality. Heart rate response to exercise (HRRE) and heart rate recovery (HRR), measures of cardiac autonomic function, are strong predictors of mortality. The present study defined the effect of age and physical activity on HRRE and HRR. Healthy women (N=72) grouped according to age (young, 20-30 years; middle, 40-50 years; and older, 65-81 years) and daily physical activity (low active <7500, high active >12,500 steps/day) performed a maximal cardiopulmonary exercise test. The HRRE was defined as an increase in heart rate from rest to 1, 3 and 5 minutes of exercise and at 1/3 of total exercise time, and HRR as the difference in heart rate between peak exercise and 1, 2, and 3 minutes later. Age was associated with a significant decline in HRRE at 1 min and 1/3 of exercise time (r= − 0.27, p=0.04, and r=−0.39, p=0.02) and HRR at 2 min and 3 min (r=−0.35, p=0.01, and r=−0.31, p=0.02). There was no significant difference in HRRE and HRR between high and low-active middle-age and older women (p>0.05). Increased level of habitual physical activity level appears to have a limited effect on age-related decline in cardiac autonomic function in women. Age and physical inactivity are important risk factors for cardiovascular mortality. Heart rate response to exercise (HRRE) and heart rate recovery (HRR), measures of cardiac autonomic function, are strong predictors of mortality. The present study defined the effect of age and physical activity on HRRE and HRR. Healthy women (N=72) grouped according to age (young, 20-30 years; middle, 40-50 years; and older, 65-81 years) and daily physical activity (low active <7500, high active >12,500 steps/day) performed a maximal cardiopulmonary exercise test. The HRRE was defined as an increase in heart rate from rest to 1, 3 and 5 minutes of exercise and at 1/3 of total exercise time, and HRR as the difference in heart rate between peak exercise and 1, 2, and 3 minutes later. Age was associated with a significant decline in HRRE at 1 min and 1/3 of exercise time (r=-0.27, p=0.04, and r=-0.39, p=0.02) and HRR at 2 min and 3 min (r=-0.35, p=0.01, and r=-0.31, p=0.02). There was no significant difference in HRRE and HRR between high and low-active middle-age and older women (p>0.05). Increased level of habitual physical activity level appears to have a limited effect on age-related decline in cardiac autonomic function in women. Age and physical inactivity are important risk factors for cardiovascular mortality. Heart rate response to exercise (HRRE) and heart rate recovery (HRR), measures of cardiac autonomic function, are strong predictors of mortality. The present study defined the effect of age and physical activity on HRRE and HRR. Healthy women (N=72) grouped according to age (young, 20-30 years; middle, 40-50 years; and older, 65-81 years) and daily physical activity (low active <7500, high active >12,500 steps/day) performed a maximal cardiopulmonary exercise test. The HRRE was defined as an increase in heart rate from rest to 1, 3 and 5 minutes of exercise and at 1/3 of total exercise time, and HRR as the difference in heart rate between peak exercise and 1, 2, and 3 minutes later. Age was associated with a significant decline in HRRE at 1 min and 1/3 of exercise time (r=-0.27, p=0.04, and r=-0.39, p=0.02) and HRR at 2 min and 3 min (r=-0.35, p=0.01, and r=-0.31, p=0.02). There was no significant difference in HRRE and HRR between high and low-active middle-age and older women (p>0.05). Increased level of habitual physical activity level appears to have a limited effect on age-related decline in cardiac autonomic function in women.Age and physical inactivity are important risk factors for cardiovascular mortality. Heart rate response to exercise (HRRE) and heart rate recovery (HRR), measures of cardiac autonomic function, are strong predictors of mortality. The present study defined the effect of age and physical activity on HRRE and HRR. Healthy women (N=72) grouped according to age (young, 20-30 years; middle, 40-50 years; and older, 65-81 years) and daily physical activity (low active <7500, high active >12,500 steps/day) performed a maximal cardiopulmonary exercise test. The HRRE was defined as an increase in heart rate from rest to 1, 3 and 5 minutes of exercise and at 1/3 of total exercise time, and HRR as the difference in heart rate between peak exercise and 1, 2, and 3 minutes later. Age was associated with a significant decline in HRRE at 1 min and 1/3 of exercise time (r=-0.27, p=0.04, and r=-0.39, p=0.02) and HRR at 2 min and 3 min (r=-0.35, p=0.01, and r=-0.31, p=0.02). There was no significant difference in HRRE and HRR between high and low-active middle-age and older women (p>0.05). Increased level of habitual physical activity level appears to have a limited effect on age-related decline in cardiac autonomic function in women. |
| Author | Njemanze, Hugo Trenell, Michael I. MacGowan, Guy A. Siervo, Mario Jakovljevic, Djordje G. Eggett, Christopher Warren, Charlotte Bates, Matthew G.D. Ivkovic, Srdjan |
| AuthorAffiliation | 6 Faculty of Medical Sciences, Centre for Rehabilitation, University of Pristina, Kosovska Mitrovica, Serbia 1 Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK 7 Clinical Research Facility, Royal Victoria Infirmary, Newcastle upon Tyne, UK 4 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK 5 Cardiothoracic Department, James Cook University Hospital, Middleborough, UK 2 MRC Centre for Ageing and Vitality, Newcastle University, UK 3 Department of Cardiology, Freeman Hospital, Newcastle upon Tyne, UK |
| AuthorAffiliation_xml | – name: 1 Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK – name: 3 Department of Cardiology, Freeman Hospital, Newcastle upon Tyne, UK – name: 4 Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK – name: 6 Faculty of Medical Sciences, Centre for Rehabilitation, University of Pristina, Kosovska Mitrovica, Serbia – name: 2 MRC Centre for Ageing and Vitality, Newcastle University, UK – name: 5 Cardiothoracic Department, James Cook University Hospital, Middleborough, UK – name: 7 Clinical Research Facility, Royal Victoria Infirmary, Newcastle upon Tyne, UK |
| Author_xml | – sequence: 1 givenname: Hugo surname: Njemanze fullname: Njemanze, Hugo organization: Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK – sequence: 2 givenname: Charlotte surname: Warren fullname: Warren, Charlotte organization: Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK, MRC Centre for Ageing and Vitality, Newcastle University, UK – sequence: 3 givenname: Christopher surname: Eggett fullname: Eggett, Christopher organization: Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK – sequence: 4 givenname: Guy A. surname: MacGowan fullname: MacGowan, Guy A. organization: Department of Cardiology, Freeman Hospital, Newcastle upon Tyne, UK, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK – sequence: 5 givenname: Matthew G.D. surname: Bates fullname: Bates, Matthew G.D. organization: Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK, Cardiothoracic Department, James Cook University Hospital, Middleborough, UK – sequence: 6 givenname: Mario surname: Siervo fullname: Siervo, Mario organization: Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK – sequence: 7 givenname: Srdjan surname: Ivkovic fullname: Ivkovic, Srdjan organization: Faculty of Medical Sciences, Centre for Rehabilitation, University of Pristina, Kosovska Mitrovica, Serbia – sequence: 8 givenname: Michael I. surname: Trenell fullname: Trenell, Michael I. organization: Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK, MRC Centre for Ageing and Vitality, Newcastle University, UK – sequence: 9 givenname: Djordje G. surname: Jakovljevic fullname: Jakovljevic, Djordje G. organization: Faculty of Medical Sciences, Institute of Cellular Medicine, MoveLab, Newcastle University, Newcastle upon Tyne, UK, MRC Centre for Ageing and Vitality, Newcastle University, UK, Clinical Research Facility, Royal Victoria Infirmary, Newcastle upon Tyne, UK |
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| Cites_doi | 10.1016/j.jacc.2013.03.031 10.1161/CIRCIMAGING.114.002086 10.1124/mi.2.7.431 10.1161/CIRCRESAHA.111.246876 10.1016/j.jmpt.2007.04.001 10.1016/j.yjmcc.2015.04.005 |
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| Keywords | Gerotarget aging cardiac autonomic function physical activity women |
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| SubjectTerms | Adult Aged Aging - physiology Autonomic Nervous System - physiology Biomarkers Blood Pressure Exercise Female Heart - innervation Heart - physiology Heart Function Tests Heart Rate Humans Middle Aged Research Paper: Gerotarget (Focus on Aging) Young Adult |
| Title | Age-related decline in cardiac autonomic function is not attenuated with increased physical activity |
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