Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects

• Published in: Diabetologia Vol. 50; no. 1; pp. 113 - 120
• Main Authors: Schrauwen-Hinderling, V. B., Kooi, M. E., Hesselink, M. K. C., Jeneson, J. A. L., Backes, W. H., van Echteld, C. J. A., van Engelshoven, J. M. A., Mensink, M., Schrauwen, P.
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.01.2007; Springer Nature B.V
• Subjects: Aged; Biological and medical sciences; Blood Glucose - metabolism; Body Mass Index; Case-Control Studies; Diabetes; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fundamental and applied biological sciences. Psychology; Humans; Insulin - metabolism; Insulin resistance; Insulin Resistance - physiology; Lipid Metabolism - physiology; Lipids; Magnetic Resonance Spectroscopy; Male; Medical sciences; Medical screening; Metabolites; Middle Aged; Mitochondria, Muscle - physiology; Muscle, Skeletal - metabolism; Musculoskeletal system; Obesity; Obesity - metabolism; Obesity - physiopathology; Overweight; Phosphocreatine - metabolism; Phosphorus Isotopes; Spectrum analysis; Striated muscle. Tendons; Vertebrates: osteoarticular system, musculoskeletal system; Netherlands; Endocrinopathy; Type 2 diabetes; Human; Oxidative capacity; Metabolic diseases; Lipids; Striated muscle; Skeletal muscle; IMCL; Insulin resistance Lipid metabolism; In vivo; Mitochondria; Mitochondrial function; Insulin resistance; Diabetes

Mitochondrial dysfunction and increased intramyocellular lipid (IMCL) content have both been implicated in the development of insulin resistance and type 2 diabetes mellitus, but the relative contributions of these two factors in the aetiology of diabetes are unknown. As obesity is an independent de...