Cyclodextrin-based nanocarriers containing a synergic drug combination: A potential formulation for pulmonary administration of antitubercular drugs

• Published in: International journal of pharmaceutics Vol. 531; no. 2; pp. 577 - 587
• Main Authors: Salzano, Giuseppina, Wankar, Jitendra, Ottani, Stefano, Villemagne, Baptiste, Baulard, Alain R., Willand, Nicolas, Brodin, Priscille, Manet, Ilse, Gref, Ruxandra
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.10.2017; Elsevier
• Subjects: Antitubercular Agents - administration & dosage; BDM43266; beta-Cyclodextrins - chemistry; Booster; Combination therapy; Drug Carriers - chemistry; Drug Combinations; Ethionamide; Ethionamide - administration & dosage; Hydroxamic Acids - administration & dosage; Life Sciences; Nanoparticles; Nanoparticles - chemistry; Polymerized β-Cyclodextrin; Triazoles - administration & dosage; Tuberculosis; Nanoparticles; Tuberculosis; Booster; BDM43266; Ethionamide; Combination therapy; Polymerized β-Cyclodextrin

[Display omitted] Tuberculosis (TB) remains a major global health problem. The use of ethionamide (ETH), a main second line drug, is associated to severe toxic side-effects due to its low therapeutic index. In this challenging context, “booster” molecules have been synthetized to increase the effica...