Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study

• Published in: Ecotoxicology and environmental safety Vol. 178; pp. 168 - 177
• Main Authors: Abolhassani, Moslem, Asadikaram, Gholamreza, Paydar, Parisa, Fallah, Hossein, Aghaee-Afshar, Mahmood, Moazed, Vahid, Akbari, Hamed, Moghaddam, Sodaif Darvish, Moradi, Afshin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 30.08.2019
• Subjects: Acetylcholinesterase; Case-Control Studies; Colorectal cancer; Colorectal Neoplasms - blood; Colorectal Neoplasms - genetics; CpG Islands; DNA Methylation; DNA Modification Methylases - genetics; DNA Repair Enzymes - genetics; Female; Genes, p16; Humans; Hydrocarbons, Chlorinated - blood; Iran; Male; Malondialdehyde - analysis; Methylation; Middle Aged; Organochlorine; Organophosphorous; Organophosphorus Compounds - blood; Oxidative stress; Pesticides - blood; Promoter Regions, Genetic; Tumor Suppressor Proteins - genetics; Iran; Oxidative stress; AChE; OPPs; α -HCH; 4,4 DDE; γ-HCH; Colorectal cancer; Organochlorine; MDA; Acetylcholinesterase; OCPs; 4,4 DDT; TAC; 2,4 DDT; Organophosphorous; β-HCH; Methylation; 2,4DDE; BMI; PON-1

Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients...