Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study
Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients...
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| Published in | Ecotoxicology and environmental safety Vol. 178; pp. 168 - 177 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier Inc
30.08.2019
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| Abstract | Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients with CRC.
In this case-control study, 42 patients with CRC and 30 healthy subjects were selected. The serum levels of some OCPs (α-HCH, β-HCH, γ-HCH, 2,4 DDE, 4,4 DDE, 2,4DDT and 4,4DDT) were measured by gas chromatography (GC) method. Serum levels of malondialdehyde (MDA), and total antioxidant capacity (TAC) as well as the enzyme activity of acetylcholinesterase (AChE) and arylesterase activity of Paraoxonase-1 (PON-1) were evaluated in all participants. The methylation specific PCR (MSP) assay was used for determining the methylation status of CpG island of p16 and MGMT genes in CRC patients.
The mean serum levels of each OCPs were significantly higher in the patient group compared to the control group (P < 0.001). The AChE and arylesterase activity of PON-1 in the patient group were significantly lower than the control group (P < 0.001). The mean serum levels of MDA and TAC in the serum of the patient group were significantly higher than the control group (P < 0.001 and P < 0.002, respectively). The current findings demonstrated significantly hypermethylation of p16 promoter in CRC patients.
Regarding the higher levels of OCPs in CRC patients, along with hypermethylation of the p16 promoter gene, diminishing in AChE and PON-1 activity and increasing in oxidative stress factors, the role of OCPs and OPPs in the CRC progression in the South-East of Iran may be assumed. |
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| AbstractList | Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients with CRC.
In this case-control study, 42 patients with CRC and 30 healthy subjects were selected. The serum levels of some OCPs (α-HCH, β-HCH, γ-HCH, 2,4 DDE, 4,4 DDE, 2,4DDT and 4,4DDT) were measured by gas chromatography (GC) method. Serum levels of malondialdehyde (MDA), and total antioxidant capacity (TAC) as well as the enzyme activity of acetylcholinesterase (AChE) and arylesterase activity of Paraoxonase-1 (PON-1) were evaluated in all participants. The methylation specific PCR (MSP) assay was used for determining the methylation status of CpG island of p16 and MGMT genes in CRC patients.
The mean serum levels of each OCPs were significantly higher in the patient group compared to the control group (P < 0.001). The AChE and arylesterase activity of PON-1 in the patient group were significantly lower than the control group (P < 0.001). The mean serum levels of MDA and TAC in the serum of the patient group were significantly higher than the control group (P < 0.001 and P < 0.002, respectively). The current findings demonstrated significantly hypermethylation of p16 promoter in CRC patients.
Regarding the higher levels of OCPs in CRC patients, along with hypermethylation of the p16 promoter gene, diminishing in AChE and PON-1 activity and increasing in oxidative stress factors, the role of OCPs and OPPs in the CRC progression in the South-East of Iran may be assumed. Among the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients with CRC.OBJECTIVESAmong the numerous agents, genetic factors and environmental elements such as pesticides have an important role in colorectal cancer (CRC) incidence. The present study aimed to investigate the probable-role of some organochlorine pesticides (OCPs) and organophosphorous pesticides (OPPs) in patients with CRC.In this case-control study, 42 patients with CRC and 30 healthy subjects were selected. The serum levels of some OCPs (α-HCH, β-HCH, γ-HCH, 2,4 DDE, 4,4 DDE, 2,4DDT and 4,4DDT) were measured by gas chromatography (GC) method. Serum levels of malondialdehyde (MDA), and total antioxidant capacity (TAC) as well as the enzyme activity of acetylcholinesterase (AChE) and arylesterase activity of Paraoxonase-1 (PON-1) were evaluated in all participants. The methylation specific PCR (MSP) assay was used for determining the methylation status of CpG island of p16 and MGMT genes in CRC patients.METHODSIn this case-control study, 42 patients with CRC and 30 healthy subjects were selected. The serum levels of some OCPs (α-HCH, β-HCH, γ-HCH, 2,4 DDE, 4,4 DDE, 2,4DDT and 4,4DDT) were measured by gas chromatography (GC) method. Serum levels of malondialdehyde (MDA), and total antioxidant capacity (TAC) as well as the enzyme activity of acetylcholinesterase (AChE) and arylesterase activity of Paraoxonase-1 (PON-1) were evaluated in all participants. The methylation specific PCR (MSP) assay was used for determining the methylation status of CpG island of p16 and MGMT genes in CRC patients.The mean serum levels of each OCPs were significantly higher in the patient group compared to the control group (P < 0.001). The AChE and arylesterase activity of PON-1 in the patient group were significantly lower than the control group (P < 0.001). The mean serum levels of MDA and TAC in the serum of the patient group were significantly higher than the control group (P < 0.001 and P < 0.002, respectively). The current findings demonstrated significantly hypermethylation of p16 promoter in CRC patients.RESULTSThe mean serum levels of each OCPs were significantly higher in the patient group compared to the control group (P < 0.001). The AChE and arylesterase activity of PON-1 in the patient group were significantly lower than the control group (P < 0.001). The mean serum levels of MDA and TAC in the serum of the patient group were significantly higher than the control group (P < 0.001 and P < 0.002, respectively). The current findings demonstrated significantly hypermethylation of p16 promoter in CRC patients.Regarding the higher levels of OCPs in CRC patients, along with hypermethylation of the p16 promoter gene, diminishing in AChE and PON-1 activity and increasing in oxidative stress factors, the role of OCPs and OPPs in the CRC progression in the South-East of Iran may be assumed.CONCLUSIONRegarding the higher levels of OCPs in CRC patients, along with hypermethylation of the p16 promoter gene, diminishing in AChE and PON-1 activity and increasing in oxidative stress factors, the role of OCPs and OPPs in the CRC progression in the South-East of Iran may be assumed. |
| Author | Abolhassani, Moslem Fallah, Hossein Akbari, Hamed Aghaee-Afshar, Mahmood Moazed, Vahid Moradi, Afshin Asadikaram, Gholamreza Moghaddam, Sodaif Darvish Paydar, Parisa |
| Author_xml | – sequence: 1 givenname: Moslem surname: Abolhassani fullname: Abolhassani, Moslem organization: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran – sequence: 2 givenname: Gholamreza surname: Asadikaram fullname: Asadikaram, Gholamreza email: asadi_ka@yahoo.com, Gh_asadi@kmu.ac.ir organization: Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran – sequence: 3 givenname: Parisa surname: Paydar fullname: Paydar, Parisa organization: Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran – sequence: 4 givenname: Hossein surname: Fallah fullname: Fallah, Hossein organization: Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran – sequence: 5 givenname: Mahmood surname: Aghaee-Afshar fullname: Aghaee-Afshar, Mahmood organization: Department of Surgery, Kerman University of Medical Sciences, Kerman, Iran – sequence: 6 givenname: Vahid surname: Moazed fullname: Moazed, Vahid organization: Hematology and Oncology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran – sequence: 7 givenname: Hamed surname: Akbari fullname: Akbari, Hamed organization: Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran – sequence: 8 givenname: Sodaif Darvish surname: Moghaddam fullname: Moghaddam, Sodaif Darvish organization: Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran – sequence: 9 givenname: Afshin surname: Moradi fullname: Moradi, Afshin organization: Cancer Research Center, Shohada Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran |
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| Keywords | Oxidative stress AChE OPPs α -HCH 4,4 DDE γ-HCH Colorectal cancer Organochlorine MDA Acetylcholinesterase OCPs 4,4 DDT TAC 2,4 DDT Organophosphorous β-HCH Methylation 2,4DDE BMI PON-1 |
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| SubjectTerms | Acetylcholinesterase Case-Control Studies Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - genetics CpG Islands DNA Methylation DNA Modification Methylases - genetics DNA Repair Enzymes - genetics Female Genes, p16 Humans Hydrocarbons, Chlorinated - blood Iran Male Malondialdehyde - analysis Methylation Middle Aged Organochlorine Organophosphorous Organophosphorus Compounds - blood Oxidative stress Pesticides - blood Promoter Regions, Genetic Tumor Suppressor Proteins - genetics |
| Title | Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study |
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