Angiotensin II Receptors in Rabbit Vascular Grafts

• Published in: Biochemical and biophysical research communications Vol. 190; no. 1; pp. 27 - 32
• Main Authors: Hausner, E.A., Turner, M.J., Trzaskos, J.M., Herblin, W.F.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.01.1993; Elsevier
• Subjects: angiotensin II; Angiotensin II - antagonists & inhibitors; Angiotensin II - metabolism; Angiotensin Receptor Antagonists; Animals; biochemical characteristics; Biological and medical sciences; Biphenyl Compounds - pharmacology; blood vessels; Carotid Arteries; endothelium; Imidazoles - pharmacology; Jugular Veins - metabolism; Jugular Veins - transplantation; Losartan; Male; Medical sciences; Muscle, Smooth, Vascular - metabolism; Rabbits; receptors; Receptors, Angiotensin - analysis; Receptors, Angiotensin - drug effects; Receptors, Angiotensin - metabolism; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Tetrazoles - pharmacology; Jugular vein; Peptide hormone; Rabbit; Lagomorpha; Vertebrata; Autograft; Mammalia; Histopathology; Bypass; Animal; Carotid; Angiotensin II; Localization; Experimental surgery; Graft surgical; Hormonal receptor
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1006/bbrc.1993.1005

New Zealand White rabbits were used as a model of autologous venous bypass grafting. A section of jugular vein was sutured into the divided common carotid artery. The animals were euthanized one month after surgery. At that time histopathology showed myointimal thickening of the graft segments. Angiotensin II receptor assays showed that the AT1 receptor was present in the grafts, concentrated in the intima. These localized receptors were shown to be similar to the prototypic vascular AT1 receptor through the use of the specific antagonist DuP 753.