Effects of methylglyoxal on human cardiac fibroblast: roles of transient receptor potential ankyrin 1 (TRPA1) channels

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 307; no. 9; pp. H1339 - H1352
• Main Authors: Oguri, Gaku, Nakajima, Toshiaki, Yamamoto, Yumiko, Takano, Nami, Tanaka, Tomofumi, Kikuchi, Hironobu, Morita, Toshihiro, Nakamura, Fumitaka, Yamasoba, Tatsuya, Komuro, Issei
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2014
• Subjects: Acetanilides - pharmacology; Allyl Compounds - pharmacology; Calcium - metabolism; Calcium Channel Blockers - pharmacology; Calcium Channels - genetics; Calcium Channels - metabolism; Calcium Signaling; Cardiomyopathy; Cell Cycle; Cell Line; Fibroblasts - drug effects; Fibroblasts - metabolism; Fluorescence; Guanidines - pharmacology; Heart Ventricles - cytology; Humans; Isocyanates - pharmacology; Nerve Tissue Proteins - agonists; Nerve Tissue Proteins - antagonists & inhibitors; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Pathogenesis; Proteins; Purines - pharmacology; Pyruvaldehyde - pharmacology; Ribonucleic acid; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Ruthenium Red - pharmacology; Smooth muscle; Transient Receptor Potential Channels - agonists; Transient Receptor Potential Channels - antagonists & inhibitors; Transient Receptor Potential Channels - genetics; Transient Receptor Potential Channels - metabolism; TRPA1 Cation Channel; human cardiac fibroblast; methylglyoxal; transient receptor potential ankyrin 1 channels

Cardiac fibroblasts contribute to the pathogenesis of cardiac remodeling. Methylglyoxal (MG) is an endogenous carbonyl compound produced under hyperglycemic conditions, which may play a role in the development of pathophysiological conditions including diabetic cardiomyopathy. However, the mechanism...