Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice

• Published in: Ecotoxicology and environmental safety Vol. 170; pp. 314 - 323
• Main Authors: Ribeiro Júnior, Gabriel, de Souza Xavier Costa, Natália, Belotti, Luciano, dos Santos Alemany, Adair Aparecida, Amato-Lourenço, Luís Fernando, da Cunha, Paula Gabriela, de Oliveira Duro, Stephanie, Ribeiro, Susan Pereira, Veras, Mariana Matera, Quirino dos Santos Lopes, Fernanda Degobbi Tenorio, Marcourakis, Tania, Nascimento Saldiva, Paulo Hilário, Poliselli Farsky, Sandra Helena, Mauad, Thais
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.04.2019
• Subjects: Air pollution; Interleukin-10; Lung aging; Sirtuin 1; Sirtuin 6; Air pollution; Interleukin-10; Sirtuin 1; Sirtuin 6; Lung aging

Life expectancy is increasing worldwide. Lung aging is a process marked by changes in multiple morphological, physiological and age-related biomarkers (e.g., sirtuins) and is influenced by external factors, such as air pollution. Hence, the elderly are considered more vulnerable to the air pollution...