Rationally synthesized coumarin based pyrazolines ameliorate carrageenan induced inflammation through COX-2/pro-inflammatory cytokine inhibition

• Published in: MedChemComm Vol. 1; no. 3; pp. 421 - 43
• Main Authors: Chandel, Priyanka, Kumar, Anoop, Singla, Nishu, Kumar, Anshul, Singh, Gagandeep, Gill, Rupinder Kaur
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.03.2019; Royal Society of Chemistry
• Subjects: Acetic acid; Acute toxicity; Analgesics; Anti-inflammatory agents; Biochemistry & Molecular Biology; Biocompatibility; Biomarkers; Carrageenan; Chemistry, Medicinal; Coumarin; Cyclooxygenase-1; Cyclooxygenase-2; Drug development; In vivo methods and tests; Inflammation; Investigations; Life Sciences & Biomedicine; Liquid oxygen; Mode of action; Molecular docking; Pharmacology & Pharmacy; Rodents; Science & Technology; Selectivity; Substance P; Synthesis; Toxicity; DESIGN; CYCLOOXYGENASE-2 COX-2; PROSTAGLANDINS; BIOLOGICAL EVALUATION; RISK; DENATURATION; SUBSTANCE-P; MOLECULAR DOCKING; DERIVATIVES; CELECOXIB

In the present work, coumarin based pyrazolines ( 7a-g ) have been synthesized and investigated for their in vitro and in vivo anti-inflammatory potential. Amongst the synthesized compounds, compounds 7a , 7d and 7f exhibited significant in vitro anti-inflammatory activity as compared to the standar...