Abnormal hemoglobin anti-Lepore Hong Kong compound with β0-thalassemia ameliorate thalassemia severity when co-inherited with α-thalassemia

• Published in: Scientific reports Vol. 14; no. 1; pp. 6682 - 9
• Main Authors: Bao, Xiuqin, Wang, Jicheng, Qin, Danqing, Yao, Cuize, Liang, Jie, Liang, Kailing, Du, Li
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208; 692/308; Anti-Lepore Hong Kong; Anti-Lepore Hong Kong compounded with β0-thalassemia and α-thalassemia; Blood diseases; Hemoglobin; Heterozygotes; Humanities and Social Sciences; Increased HbA2; Meiosis; mRNA; multidisciplinary; Science; Science (multidisciplinary); Single molecular real time sequencing; Thalassemia; Hong Kong China; China; Anti-Lepore Hong Kong; Increased HbA2; thalassemia and α-thalassemia; Single molecular real time sequencing; Anti-Lepore Hong Kong compounded with β

Abnormal hemoglobin anti-Lepore Hong Kong is a rare βδ fusion variants resulting from non-homologous crossover during meiosis. Anti-Lepore Hong Kong is known to consistently exhibit significantly increased level of HbA2. In this study, we used multiplex ligation-dependent probe amplification (MLPA)...