Chronic bilateral renal denervation attenuates renal injury in a transgenic rat model of diabetic nephropathy

• Published in: American journal of physiology. Renal physiology Vol. 307; no. 3; pp. F251 - F262
• Main Authors: Yao, Yimin, Fomison-Nurse, Ingrid C., Harrison, Joanne C., Walker, Robert J., Davis, Gerard, Sammut, Ivan A.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.08.2014
• Subjects: Acute Kidney Injury - pathology; Acute Kidney Injury - physiopathology; Acute Kidney Injury - prevention & control; Animals; Basement Membrane - pathology; Denervation - methods; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - complications; Diabetic Nephropathies - complications; Diabetic Nephropathies - pathology; Diabetic Nephropathies - physiopathology; Disease Models, Animal; Disease Progression; Female; Fibrosis; Heterozygote; Hypertension; Immunohistochemistry; Kidney - innervation; Kidney diseases; Kidney Glomerulus - pathology; Proteins; Rats; Rats, Transgenic; Renin - genetics; Renin - physiology; Rodents; Streptozocin - adverse effects; fibrosis; (mRen-2)27 rat; renal denervation; diabetic nephropathy

Bilateral renal denervation (BRD) has been shown to reduce hypertension and improve renal function in both human and experimental studies. We hypothesized that chronic intervention with BRD may also attenuate renal injury and fibrosis in diabetic nephropathy. This hypothesis was examined in a female...