Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model

• Published in: Thrombosis and haemostasis Vol. 119; no. 11; p. 1740
• Main Authors: Yamakawa, Kazuma, Gando, Satoshi, Ogura, Hiroshi, Umemura, Yutaka, Kabata, Daijiro, Shintani, Ayumi, Shiraishi, Atsushi, Saitoh, Daizoh, Fujishima, Seitato, Mayumi, Toshihiko, Kushimoto, Shigeki, Abe, Toshikazu, Shiino, Yasukazu, Nakada, Taka-Aki, Tarui, Takehiko, Hifumi, Toru, Otomo, Yasuhiro, Okamoto, Kohji, Kotani, Joji, Sakamoto, Yuichiro, Sasaki, Junichi, Shiraishi, Shin-Ichiro, Takuma, Kiyotsugu, Tsuruta, Ryosuke, Hagiwara, Akiyoshi, Masuno, Tomohiko, Takeyama, Naoshi, Yamashita, Norio, Ikeda, Hiroto, Ueyama, Masashi, Fujimi, Satoshi
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2019
• Subjects: Aged; Aged, 80 and over; Anticoagulants - adverse effects; Anticoagulants - therapeutic use; Blood Coagulation - drug effects; Clinical Decision-Making; Decision Support Techniques; Disseminated Intravascular Coagulation - blood; Disseminated Intravascular Coagulation - diagnosis; Disseminated Intravascular Coagulation - drug therapy; Disseminated Intravascular Coagulation - mortality; Female; Hospital Mortality; Humans; Japan; Male; Middle Aged; Patient Selection; Predictive Value of Tests; Prospective Studies; Registries; Risk Assessment; Risk Factors; Sepsis - blood; Sepsis - diagnosis; Sepsis - drug therapy; Sepsis - mortality; Severity of Illness Index; Time Factors; Treatment Outcome; Japan

Anticoagulant therapy has seldom been achieved in randomized trials targeting nonspecific overall sepsis patients. Although the key components to identify the appropriate target in sepsis may be disseminated intravascular coagulation (DIC) and high disease severity, the interaction and relation of t...