Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression - Tang, Chih-Min; Lee, Tracy E.; Syed, Sabriya A.; Burgoyne, Adam M.; Leonard, Stephanie Y.; Gao, Fei; Chan, Jonathan C.; Shi, Eileen; Chmielecki, Juliann; Morosini, Deborah; Wang, Kai; Ross, Jeffrey S.; et al. (Oncotarget, 2016)
Keywords: Antineoplastic Agents - pharmacology; Arsenicals - pharmacology; Binding Sites; Cell Line, Tumor; Cell Survival; Cilia - metabolism; Cilia - pathology; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gastrointestinal Neoplasms - drug therapy; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - metabolism; Gastrointestinal Neoplasms - pathology; Gastrointestinal Stromal Tumors - drug therapy; Gastrointestinal Stromal Tumors - genetics; Gastrointestinal Stromal Tumors - metabolism; Gastrointestinal Stromal Tumors - pathology; Gene Expression Regulation, Neoplastic; Humans; Imatinib Mesylate - pharmacology; Interstitial Cells of Cajal - drug effects; Interstitial Cells of Cajal - metabolism; Interstitial Cells of Cajal - pathology; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nuclear Proteins - antagonists & inhibitors; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oxides - pharmacology; Priority Research Paper; Promoter Regions, Genetic; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Receptor, Platelet-Derived Growth Factor alpha - genetics; RNA Interference; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction - drug effects; Transfection; Zinc Finger Protein GLI1 - antagonists & inhibitors; Zinc Finger Protein GLI1 - genetics; Zinc Finger Protein GLI1 - metabolism; Zinc Finger Protein Gli2 - antagonists & inhibitors; Zinc Finger Protein Gli2 - genetics; Zinc Finger Protein Gli2 - metabolism; Zinc Finger Protein Gli3 - genetics; Zinc Finger Protein Gli3 - metabolism; imatinib-resistant; ICC; GIST; GLI; arsenic trioxide