Identification of potential genetic causal variants for rheumatoid arthritis by whole-exome sequencing

• Published in: Oncotarget Vol. 8; no. 67; pp. 111119 - 111129
• Main Authors: Li, Ying, Lai-Han Leung, Elaine, Pan, Hudan, Yao, Xiaojun, Huang, Qingchun, Wu, Min, Xu, Ting, Wang, Yuwei, Cai, Jun, Li, Runze, Liu, Wei, Liu, Liang
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 19.12.2017
• Subjects: Research Paper; Chinese population; genetic causal variants; homology modeling; rheumatoid arthritis; whole-exome sequencing

Rheumatoid arthritis (RA) is a highly prevalent chronic autoimmune disease. However, genetic and environmental factors involved in RA pathogenesis are still remained largely unknown. To identify the genetic causal variants underlying pathogenesis and disease progression of RA patients, we undertook...