Development and validation of a stability-indicating LC method for simultaneous determination of related compounds of guaifenesin, terbutaline sulfate and ambroxol HCl in cough syrup formulation

• Published in: Journal of Saudi Chemical Society Vol. 18; no. 5; pp. 593 - 600
• Main Authors: Lakshmi Narasimha Rao, K., Krishnaiah, Ch, Sudheer Babu, K., Padmaja Reddy, K.
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Elsevier B.V 01.11.2014; Saudi Chemical Society
• Subjects: Ambroxol HCl; Analysis; Development and validation; Drug stability; Guaifenesin; High performance liquid chromatography; HPLC; Impurities; Stability indicating; Syrup formulations; Terbutaline sulfate; Impurities; Development and validation; Stability indicating; Guaifenesin; Ambroxol HCl; Syrup formulations; Terbutaline sulfate; HPLC

A new liquid chromatographic method has been developed and validated for the determination of terbutaline sulfate (TLS), guaifenesin (GFN) and ambroxol HCl (AML), for its potential impurities in drug substances and drug products. Efficient chromatographic separation was achieved on X-Terra RP-18 col...