A review on sensing mechanisms and strategies for telomerase activity detection

• Published in: TrAC, Trends in analytical chemistry (Regular ed.) Vol. 134; p. 116115
• Main Authors: Wang, Danni, Xue, Wanyi, Ren, Xiuyan, Xu, Zhangrun
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2021
• Subjects: analytical chemistry; assays; biomarkers; detection; DNA probes; early diagnosis; Electronegativity; Guanine-rich tail; Hybridization reaction; nucleic acid hybridization; prognosis; screening; Sensing mechanism; tail; Telomerase; Electronegativity; Telomerase; Sensing mechanism; Hybridization reaction; Guanine-rich tail

Telomerase is a valuable biomarker for early diagnosis and prognosis of cancer, as well as anticancer-drug screening. In this review, we focus on the general sensing mechanisms behind the advanced methods for telomerase activity detection. In terms of the unique properties of telomerase-extended pri...