Structure-activity relationships of antimalarial indolo[3,2- c]quinolines [1, 2]
Structure-activity relationships have been ascertained and chemical methodology developed for a series of antimalarial 3-chloroindolo[3,2 - c]quinoline-5-oxides. The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3. Substit...
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Published in | European journal of medicinal chemistry Vol. 28; no. 11; pp. 837 - 852 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Masson SAS
1993
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Structure-activity relationships have been ascertained and chemical methodology developed for a series of antimalarial 3-chloroindolo[3,2 -
c]quinoline-5-oxides. The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3. Substitution at positions 7, 8, 9, 10 is not essential, although the most potent analog in our studies was the 8-nitro compound
4vv. |
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ISSN: | 0223-5234 1768-3254 |
DOI: | 10.1016/0223-5234(93)90036-E |