Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens

Natural products along with their analogs have been intensively explored for their antimicrobial potential against ‘ESKAPE’ pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin ( 1 ), along with its decomposed product peniformamide ( 2 ), and the k...

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Published inJournal of antibiotics Vol. 76; no. 3; pp. 113 - 120
Main Authors Yang, Jiafan, Song, Yongxiang, Zhou, Zhenbin, Huang, Yun, Wang, Songtao, Yuan, Jie, Wong, Nai-Kei, Yan, Yan, Ju, Jianhua
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.03.2023
Springer Nature
Nature Publishing Group
Subjects
631/326/22/1290
631/92/349
Anti-Bacterial Agents - chemistry
Anti-Infective Agents - chemistry
Antibacterial activity
Antimicrobial activity
Antimicrobial agents
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Biotechnology & Applied Microbiology
Cell Line, Tumor
Cytotoxicity
Deep sea
Deep sea environments
Fungi
Humans
Immunology
Lead compounds
Life Sciences
Life Sciences & Biomedicine
Medicinal Chemistry
Microbiology
Molecular Structure
Natural products
Organic Chemistry
Pathogens
Penicillium
Penicillium - chemistry
Pharmacology & Pharmacy
Science & Technology
Toxicity
Tumor cell lines
XANTHOCILLIN
ESKAPE
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Abstract Natural products along with their analogs have been intensively explored for their antimicrobial potential against ‘ESKAPE’ pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin ( 1 ), along with its decomposed product peniformamide ( 2 ), and the known compound xanthocillin X ( 3 ) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06–8.0 μg mL −1 . As an artificial unnatural product during the isolation process, compound 2 had lower antimicrobial activity than that of compound 1 , which could be attributed to a change in structural modification from an isonitrile group in compound 1 to a formamide group in compound 2 . In terms of cytotoxicity, 1 showed relatively low cytotoxicity against human tumor cell lines compared with xanthocillin X ( 3 ), suggesting that the sulfate group present in 1 should be a determinant of cytotoxic activities. Overall, sulfoxanthocillin ( 1 ) merits further attention as a potential lead compound for anti-infective interventions against Gram-negative and Gram-positive bacterial pathogens.
AbstractList Natural products along with their analogs have been intensively explored for their antimicrobial potential against 'ESKAPE' pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin (1), along with its decomposed product peniformamide (2), and the known compound xanthocillin X (3) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06-8.0 μg mL-1. As an artificial unnatural product during the isolation process, compound 2 had lower antimicrobial activity than that of compound 1, which could be attributed to a change in structural modification from an isonitrile group in compound 1 to a formamide group in compound 2. In terms of cytotoxicity, 1 showed relatively low cytotoxicity against human tumor cell lines compared with xanthocillin X (3), suggesting that the sulfate group present in 1 should be a determinant of cytotoxic activities. Overall, sulfoxanthocillin (1) merits further attention as a potential lead compound for anti-infective interventions against Gram-negative and Gram-positive bacterial pathogens.Natural products along with their analogs have been intensively explored for their antimicrobial potential against 'ESKAPE' pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin (1), along with its decomposed product peniformamide (2), and the known compound xanthocillin X (3) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06-8.0 μg mL-1. As an artificial unnatural product during the isolation process, compound 2 had lower antimicrobial activity than that of compound 1, which could be attributed to a change in structural modification from an isonitrile group in compound 1 to a formamide group in compound 2. In terms of cytotoxicity, 1 showed relatively low cytotoxicity against human tumor cell lines compared with xanthocillin X (3), suggesting that the sulfate group present in 1 should be a determinant of cytotoxic activities. Overall, sulfoxanthocillin (1) merits further attention as a potential lead compound for anti-infective interventions against Gram-negative and Gram-positive bacterial pathogens.
Natural products along with their analogs have been intensively explored for their antimicrobial potential against 'ESKAPE' pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin (1), along with its decomposed product peniformamide (2), and the known compound xanthocillin X (3) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06-8.0 mu g mL(-1). As an artificial unnatural product during the isolation process, compound 2 had lower antimicrobial activity than that of compound 1, which could be attributed to a change in structural modification from an isonitrile group in compound 1 to a formamide group in compound 2. In terms of cytotoxicity, 1 showed relatively low cytotoxicity against human tumor cell lines compared with xanthocillin X (3), suggesting that the sulfate group present in 1 should be a determinant of cytotoxic activities. Overall, sulfoxanthocillin (1) merits further attention as a potential lead compound for anti-infective interventions against Gram-negative and Gram-positive bacterial pathogens.
Natural products along with their analogs have been intensively explored for their antimicrobial potential against 'ESKAPE' pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin (1), along with its decomposed product peniformamide (2), and the known compound xanthocillin X (3) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06-8.0 μg mL . As an artificial unnatural product during the isolation process, compound 2 had lower antimicrobial activity than that of compound 1, which could be attributed to a change in structural modification from an isonitrile group in compound 1 to a formamide group in compound 2. In terms of cytotoxicity, 1 showed relatively low cytotoxicity against human tumor cell lines compared with xanthocillin X (3), suggesting that the sulfate group present in 1 should be a determinant of cytotoxic activities. Overall, sulfoxanthocillin (1) merits further attention as a potential lead compound for anti-infective interventions against Gram-negative and Gram-positive bacterial pathogens.
Natural products along with their analogs have been intensively explored for their antimicrobial potential against ‘ESKAPE’ pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin (1), along with its decomposed product peniformamide (2), and the known compound xanthocillin X (3) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06–8.0 μg mL−1. As an artificial unnatural product during the isolation process, compound 2 had lower antimicrobial activity than that of compound 1, which could be attributed to a change in structural modification from an isonitrile group in compound 1 to a formamide group in compound 2. In terms of cytotoxicity, 1 showed relatively low cytotoxicity against human tumor cell lines compared with xanthocillin X (3), suggesting that the sulfate group present in 1 should be a determinant of cytotoxic activities. Overall, sulfoxanthocillin (1) merits further attention as a potential lead compound for anti-infective interventions against Gram-negative and Gram-positive bacterial pathogens.
Natural products along with their analogs have been intensively explored for their antimicrobial potential against ‘ESKAPE’ pathogens. Herein, we report a new natural product with strong antibacterial activity, sulfoxanthocillin ( 1 ), along with its decomposed product peniformamide ( 2 ), and the known compound xanthocillin X ( 3 ) from the deep-sea derived Penicillium sp. SCSIO sof101. The structures of compounds 1 and 2 were determined by extensive spectroscopic analysis. Compound 1 showed significant activity against series pathogens with MIC values ranging 0.06–8.0 μg mL −1 . As an artificial unnatural product during the isolation process, compound 2 had lower antimicrobial activity than that of compound 1 , which could be attributed to a change in structural modification from an isonitrile group in compound 1 to a formamide group in compound 2 . In terms of cytotoxicity, 1 showed relatively low cytotoxicity against human tumor cell lines compared with xanthocillin X ( 3 ), suggesting that the sulfate group present in 1 should be a determinant of cytotoxic activities. Overall, sulfoxanthocillin ( 1 ) merits further attention as a potential lead compound for anti-infective interventions against Gram-negative and Gram-positive bacterial pathogens.
Author Ju, Jianhua
Zhou, Zhenbin
Wong, Nai-Kei
Wang, Songtao
Yuan, Jie
Yan, Yan
Song, Yongxiang
Huang, Yun
Yang, Jiafan
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CitedBy_id crossref_primary_10_1002_cbdv_202301278
crossref_primary_10_3390_md22050191
crossref_primary_10_1039_D4NP00067F
crossref_primary_10_3390_md22010021
crossref_primary_10_1002_cbdv_202402685
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2023. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
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Keywords XANTHOCILLIN
ESKAPE
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Snippet Natural products along with their analogs have been intensively explored for their antimicrobial potential against ‘ESKAPE’ pathogens. Herein, we report a new...
Natural products along with their analogs have been intensively explored for their antimicrobial potential against 'ESKAPE' pathogens. Herein, we report a new...
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StartPage 113
SubjectTerms 631/326/22/1290
631/92/349
Anti-Bacterial Agents - chemistry
Anti-Infective Agents - chemistry
Antibacterial activity
Antimicrobial activity
Antimicrobial agents
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Biotechnology & Applied Microbiology
Cell Line, Tumor
Cytotoxicity
Deep sea
Deep sea environments
Fungi
Humans
Immunology
Lead compounds
Life Sciences
Life Sciences & Biomedicine
Medicinal Chemistry
Microbiology
Molecular Structure
Natural products
Organic Chemistry
Pathogens
Penicillium
Penicillium - chemistry
Pharmacology & Pharmacy
Science & Technology
Toxicity
Tumor cell lines
Title Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens
URI https://link.springer.com/article/10.1038/s41429-022-00593-9
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https://www.ncbi.nlm.nih.gov/pubmed/36642755
https://www.proquest.com/docview/2779963372
https://www.proquest.com/docview/2766065961
Volume 76
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