Evaluation of the cytotoxicity of cyclodextrins and hydroxypropylated derivatives
The haemolytic effect toward human erythrocytes and the cytotoxicity toward P388 cells of the three natural cyclodextrins and their hydroxypropylated derivatives have been compared. The cytotoxicity of the six cyclodextrins toward these two cell types follows a similar pattern, and the curve paramet...
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| Published in | International journal of pharmaceutics Vol. 101; no. 1; pp. 97 - 103 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
1994
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The haemolytic effect toward human erythrocytes and the cytotoxicity toward P388 cells of the three natural cyclodextrins and their hydroxypropylated derivatives have been compared. The cytotoxicity of the six cyclodextrins toward these two cell types follows a similar pattern, and the curve parameters are generally of the same order of magnitude for both cell types in spite of the biological differences. The in vitro cytotoxic effect decreases in the order βCD > αCD > γCD and HPβCD > HPγCD > = HPαCD. These results showed that phenomena involved in cyclodextrin cytotoxicity are not specific to the cell type, and bore out the hypothesis of destruction of membranes by the removal of basic membrane components. Moreover, they demonstrated the influence of parameters other than CD concentration, i.e., the presence of serum components, or the density of the cells, which can dramatically influence the cytotoxic effect of CDs. In fact, the cytotoxicity of a cyclodextrin is determined by the relative proportion of cellular and extracellular molecules likely to be included and cyclodextrins. |
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| AbstractList | The haemolytic effect toward human erythrocytes and the cytotoxicity toward P388 cells of the three natural cyclodextrins and their hydroxypropylated derivatives have been compared. The cytotoxicity of the six cyclodextrins toward these two cell types follows a similar pattern, and the curve parameters are generally of the same order of magnitude for both cell types in spite of the biological differences. The in vitro cytotoxic effect decreases in the order βCD > αCD > γCD and HPβCD > HPγCD > = HPαCD. These results showed that phenomena involved in cyclodextrin cytotoxicity are not specific to the cell type, and bore out the hypothesis of destruction of membranes by the removal of basic membrane components. Moreover, they demonstrated the influence of parameters other than CD concentration, i.e., the presence of serum components, or the density of the cells, which can dramatically influence the cytotoxic effect of CDs. In fact, the cytotoxicity of a cyclodextrin is determined by the relative proportion of cellular and extracellular molecules likely to be included and cyclodextrins. |
| Author | Andreux, Jean-Paul Duchêne, Dominique Leroy-Lechat, Frédérique Puisieux, F. Wouessidjewe, Denis |
| Author_xml | – sequence: 1 givenname: Frédérique surname: Leroy-Lechat fullname: Leroy-Lechat, Frédérique organization: Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, URA CNRS 1218 France – sequence: 2 givenname: Denis surname: Wouessidjewe fullname: Wouessidjewe, Denis organization: Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, URA CNRS 1218 France – sequence: 3 givenname: Jean-Paul surname: Andreux fullname: Andreux, Jean-Paul organization: Laboratoire d'hématologie, Université de Paris XI, Rue Jean Baptiste Clément, 92296 Châtenay Malabry Cédex, France – sequence: 4 givenname: F. surname: Puisieux fullname: Puisieux, F. organization: Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, URA CNRS 1218 France – sequence: 5 givenname: Dominique surname: Duchêne fullname: Duchêne, Dominique organization: Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, URA CNRS 1218 France |
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| Keywords | Cyclodextrin P388 cell Cytotoxicity Serum Inclusion ability Hydroxypropylated cyclodextrin In vitro hemolysis Cell density Human Hemolysis Toxicity Oligosaccharide P388-Leukemia Red blood cell In vitro Blood Inclusion compound Tumor cell |
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| SubjectTerms | Biological and medical sciences Cell density Cyclodextrin Cytotoxicity Drug toxicity and drugs side effects treatment Hydroxypropylated cyclodextrin In vitro hemolysis Inclusion ability Medical sciences P388 cell Pharmacology. Drug treatments Serum Toxicity: blood |
| Title | Evaluation of the cytotoxicity of cyclodextrins and hydroxypropylated derivatives |
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