Protein tyrosine phosphatase 1B inhibitory activity of lavandulyl flavonoids from roots of Sophora flavescens

• Published in: Planta medica Vol. 80; no. 7; p. 557
• Main Authors: Sasaki, Tatsunori, Li, Wei, Higai, Koji, Quang, Tran Hong, Kim, Young Ho, Koike, Kazuo
• Format: Journal Article
• Language: English
• Published: Germany 01.05.2014
• Subjects: Chalcones - chemistry; Chalcones - isolation & purification; Chalcones - pharmacology; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Hep G2 Cells; Humans; Inhibitory Concentration 50; Insulin - metabolism; Kinetics; Monoterpenes - chemistry; Monoterpenes - isolation & purification; Monoterpenes - pharmacology; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Roots - chemistry; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors; Protein Tyrosine Phosphatases - antagonists & inhibitors; Signal Transduction - drug effects; Small Molecule Libraries; Sophora - chemistry

Protein tyrosine phosphatase 1B is a non-transmembrane protein tyrosine phosphatase and major negative regulator in insulin signaling cascades, and much attention has been paid to protein tyrosine phosphatase 1B inhibitors as potential therapies for diabetes. The screening of a natural compound libr...