Cytogenetic findings in 14 benign cartilaginous neoplasms

Benign cartilaginous tumors represent a spectrum of neoplastic processes with variable clinical and pathologic presentations. These tumors are histologically characterized by the presence of chondrocytes surrounded by a cartilaginous matrix. Few studies describe karyotypic abnormalities in these ben...

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Published inCancer genetics Vol. 204; no. 4; pp. 180 - 186
Main Authors Sakai Junior, Nilo, Abe, Kikue Terada, Formigli, Lia Menezes, Pereira, Marcio Fernandes, de Oliveira, Maria Dulce Valverde, Cornelio, Deborah Afonso, de La Roque Ferreira, Alessandra, Kalil, Ricardo Karam
Format Journal Article
LanguageEnglish
Published United States 01.04.2011
Subjects
Adolescent
Adult
Benign
Child
Child, Preschool
Chondroma - genetics
Chondroma - pathology
Chromosome Aberrations
Female
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization, Fluorescence
Infant
Karyotyping
Male
Medical Education
Middle Aged
Translocation, Genetic
cytogenetics
Chondromas
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Abstract Benign cartilaginous tumors represent a spectrum of neoplastic processes with variable clinical and pathologic presentations. These tumors are histologically characterized by the presence of chondrocytes surrounded by a cartilaginous matrix. Few studies describe karyotypic abnormalities in these benign lesions. We report a series of 14 chondromas from a single institution. Conventional cytogenetics was performed on short term cultures from all cases. Clonal chromosome aberrations were found in nine tumors. One soft tissue chondroma contained three clones with t(6;12)(q12;p11.2), t(3;7)(q13;p12), and der(2)t(2;18)(p11.2;q11.2). Three periosteal chondromas displayed random structural aberrations of chromosomes 2, 3, 6, 7, and 11 and loss of chromosome 13. Among the enchondromas, three tumors displayed chromosome losses, one contained a complex translocation involving chromosomes 12, 15, and 21 as well as an inv(2)(p21q31),t(12;15;21)(q13;q14;q22) and a separate enchondroma showed a translocation involving chromosomes 12 and 22. Our data suggest that considerable cytogenetic heterogeneity exists among benign chondromatous tumors.
AbstractList Benign cartilaginous tumors represent a spectrum of neoplastic processes with variable clinical and pathologic presentations. These tumors are histologically characterized by the presence of chondrocytes surrounded by a cartilaginous matrix. Few studies describe karyotypic abnormalities in these benign lesions. We report a series of 14 chondromas from a single institution. Conventional cytogenetics was performed on short term cultures from all cases. Clonal chromosome aberrations were found in nine tumors. One soft tissue chondroma contained three clones with t(6; 12)(q12; p11.2), t(3; 7)(q13; p12), and der(2)t(2; 18)(p11.2; q11.2). Three periosteal chondromas displayed random structural aberrations of chromosomes 2, 3, 6, 7, and 11 and loss of chromosome 13. Among the enchondromas, three tumors displayed chromosome losses, one contained a complex translocation involving chromosomes 12, 15, and 21 as well as an inv(2)(p21q31),t(12; 15; 21)(q13; q14; q22) and a separate enchondroma showed a translocation involving chromosomes 12 and 22. Our data suggest that considerable cytogenetic heterogeneity exists among benign chondromatous tumors.
Author Cornelio, Deborah Afonso
Formigli, Lia Menezes
Sakai Junior, Nilo
de Oliveira, Maria Dulce Valverde
Pereira, Marcio Fernandes
Abe, Kikue Terada
Kalil, Ricardo Karam
de La Roque Ferreira, Alessandra
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Snippet Benign cartilaginous tumors represent a spectrum of neoplastic processes with variable clinical and pathologic presentations. These tumors are histologically...
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SubjectTerms Adolescent
Adult
Benign
Child
Child, Preschool
Chondroma - genetics
Chondroma - pathology
Chromosome Aberrations
Female
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization, Fluorescence
Infant
Karyotyping
Male
Medical Education
Middle Aged
Translocation, Genetic
Title Cytogenetic findings in 14 benign cartilaginous neoplasms
URI https://www.clinicalkey.es/playcontent/1-s2.0-S2210776211000494
https://www.ncbi.nlm.nih.gov/pubmed/21536235
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https://search.proquest.com/docview/904494083
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