Effects of intracellular and extracellular concentrations of Ca2+, K+, and Cl- on the Na+-dependent Mg2+ efflux in rat ventricular myocytes

• Published in: Biophysical journal Vol. 91; no. 1; pp. 244 - 254
• Main Authors: Tashiro, Michiko, Tursun, Pulat, Miyazaki, Takefumi, Watanabe, Masaru, Konishi, Masato
• Format: Journal Article
• Language: English
• Published: United States Biophysical Society 01.07.2006
• Subjects: Animals; Biological Transport, Active - physiology; Calcium - metabolism; Cell Membrane - physiology; Cells, Cultured; Chlorine - metabolism; Extracellular Fluid - metabolism; Heart Ventricles - drug effects; Heart Ventricles - metabolism; Intracellular Fluid - metabolism; Magnesium - metabolism; Male; Membranes; Myocytes, Cardiac - physiology; Potassium - metabolism; Rats; Rats, Wistar; Sodium - metabolism

Intracellular Mg2+ concentration ([Mg2+]i) was measured in rat ventricular myocytes with the fluorescent indicator furaptra (25 degrees C). After the myocytes were loaded with Mg2+, the initial rate of decrease in [Mg2+]i (initial Delta[Mg2+]i/Deltat) was estimated upon introduction of extracellular...