The decrease in NKG2D+ Natural Killer cells in peripheral blood of patients with metastatic colorectal cancer

• Published in: Bratislavské lékarské listy Vol. 116; no. 5; pp. 296 - 301
• Main Authors: Gharagozloo, M, Kalantari, H, Rezaei, A, Maracy, M R, Salehi, M, Bahador, A, Hassannejad, N, Narimani, M, Sanei, M H, Bayat, B, Ghazanfari, H
• Format: Journal Article
• Language: English
• Published: Slovakia 2015
• Subjects: Adult; Aged; Case-Control Studies; Colorectal Neoplasms - immunology; Colorectal Neoplasms - pathology; Female; Flow Cytometry; Humans; Killer Cells, Natural - immunology; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasm Metastasis; NK Cell Lectin-Like Receptor Subfamily K - genetics; NK Cell Lectin-Like Receptor Subfamily K - immunology; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; NK cells; NKG2D; colorectal cancer; metastasis

Natural killer (NK) cells play important roles in the immune defense against tumors such as colorectal cancer. In humans, NKG2D is an activating immune receptor constitutively expressed in most cytotoxic lymphocytes including NK and CD8+ T cells. In this study, the expression of NKG2D molecule was i...