Intestinal lead and calcium absorption: effect of 1,25-dihydroxycholecalciferol and lead status
This study was designed to investigate, in some detail, the relative effects of the hormonal form of vitamin D (1,25-dihydroxycholecalciferol) on duodenal Pb and Ca absorption as a function of dietary Pb level. When cholecalciferol-deficient chicks were chronically repleted with physiologic levels o...
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Published in | Proceedings of the Society for Experimental Biology and Medicine Vol. 194; no. 3; p. 258 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
01.07.1990
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Abstract | This study was designed to investigate, in some detail, the relative effects of the hormonal form of vitamin D (1,25-dihydroxycholecalciferol) on duodenal Pb and Ca absorption as a function of dietary Pb level. When cholecalciferol-deficient chicks were chronically repleted with physiologic levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), as the sole source of the vitamin, 203Pb and 47Ca absorption were enhanced over 4- and 8-fold, respectively. Ingestion of Pb during the repletion period had no significant effect on the intestinal Ca absorption response to 1,25-(OH)2D3 even at a very high dietary Pb level. The efficiency of intestinal 203Pb absorption was, however, significantly diminished by dietary Pb, in an apparent dose-dependent fashion. The results indicate that the extent to which systemic Ca homeostatic mechanisms influence intestinal Pb absorption is dependent, in large part, on Pb status. |
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AbstractList | This study was designed to investigate, in some detail, the relative effects of the hormonal form of vitamin D (1,25-dihydroxycholecalciferol) on duodenal Pb and Ca absorption as a function of dietary Pb level. When cholecalciferol-deficient chicks were chronically repleted with physiologic levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3), as the sole source of the vitamin, 203Pb and 47Ca absorption were enhanced over 4- and 8-fold, respectively. Ingestion of Pb during the repletion period had no significant effect on the intestinal Ca absorption response to 1,25-(OH)2D3 even at a very high dietary Pb level. The efficiency of intestinal 203Pb absorption was, however, significantly diminished by dietary Pb, in an apparent dose-dependent fashion. The results indicate that the extent to which systemic Ca homeostatic mechanisms influence intestinal Pb absorption is dependent, in large part, on Pb status. |
Author | Fullmer, C S |
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CitedBy_id | crossref_primary_10_1093_jn_122_7_1351 crossref_primary_10_1039_c2tx20064c crossref_primary_10_1080_10408398_2017_1302407 crossref_primary_10_3382_ps_pez330 crossref_primary_10_1006_enrs_1996_3689 crossref_primary_10_1016_S0985_0562_05_80268_7 crossref_primary_10_1016_j_emctp_2004_10_004 crossref_primary_10_1016_S1155_1925_05_38475_8 crossref_primary_10_1186_1476_069X_14_5 crossref_primary_10_1177_0960327107070573 crossref_primary_10_1007_BF03345710 crossref_primary_10_1196_annals_1306_011 crossref_primary_10_1289_ehp_9448 |
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SubjectTerms | Alkaline Phosphatase - biosynthesis Animals Body Weight Calbindins Calcitriol - administration & dosage Calcium - blood Calcium - metabolism Chickens Cholecalciferol - deficiency Diet Dose-Response Relationship, Drug Duodenum - metabolism Intestinal Absorption Lead - administration & dosage Lead - metabolism Male Phosphorus - blood S100 Calcium Binding Protein G - biosynthesis Vitamin D Deficiency - metabolism |
Title | Intestinal lead and calcium absorption: effect of 1,25-dihydroxycholecalciferol and lead status |
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