Human Megasatellite DNA RS447: Copy-Number Polymorphisms and Interspecies Conservation

• Published in: Genomics (San Diego, Calif.) Vol. 54; no. 1; pp. 39 - 49
• Main Authors: Gondo, Yoichi, Okada, Takeya, Matsuyama, Noriko, Saitoh, Yasushi, Yanagisawa, Yoshiko, Ikeda, Joh-E
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.11.1998; Elsevier
• Subjects: Animals; Base Sequence; Biological and medical sciences; Blotting, Southern; Chromosome Mapping; Classical genetics, quantitative genetics, hybrids; Conserved Sequence; DNA, Satellite - genetics; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Polyacrylamide Gel; Fundamental and applied biological sciences. Psychology; Gene Dosage; Genetics of eukaryotes. Biological and molecular evolution; Human; Humans; In Situ Hybridization, Fluorescence; Japan; Mammals - genetics; Polymorphism, Genetic; Sequence Analysis, DNA; Species Specificity; Asia; Japan; Genetic mapping; Satellite DNA; Human; Genome organization; Genetic marker; Copy number; Chromosome B4; Tandemly repeated sequence; Chromosome C8; Polymorphism

We previously isolated a novel 4.7-kb RS447 sequence, which tandemly repeated approximately 50–70 copies and resided on human chromosome 4p15 (M. Kogiet al.,1997, Genomics 42: 278–283). Another tandem array (or arrays) of several RS447 copies was hereby identified on the distal part of chromosome 8p...