GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway

• Published in: Oncotarget Vol. 8; no. 1; pp. 1508 - 1528
• Main Authors: Li, Yan-Liang, Chang, Joseph T., Lee, Li-Yu, Fan, Kang-Hsing, Lu, Ya-Ching, Li, Yi-Chen, Chiang, Chang-Hsu, You, Guo-Rung, Chen, Hsin-Ying, Cheng, Ann-Joy
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 03.01.2017
• Subjects: Animals; Cell Line, Tumor; Growth Differentiation Factor 15 - metabolism; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - radiotherapy; Heterografts; Humans; Mice; Mice, Inbred BALB C; Radiation Tolerance; Random Allocation; Reactive Oxygen Species - metabolism; Research Paper; Signal Transduction; Smad Proteins - metabolism; head and neck cancer (HNC); reactive oxygen species (ROS); GDF15; radioresistance; cancer stemness

Radiotherapy is an integral part for the treatment of head and neck cancer (HNC), while radioresistance is a major cause leads to treatment failure. GDF15, a member of the TGF-β superfamily, is hypothesized to participate in various types of homeostasis. However, the potential role of this molecule...