Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis

• Published in: Oncotarget Vol. 8; no. 40; pp. 66987 - 67000
• Main Authors: Zhao, Jia-Xing, Yuan, Ya-Wei, Cai, Cheng-Fu, Shen, Dong-Yan, Chen, Mao-Li, Ye, Feng, Mi, Yan-Jun, Luo, Qi-Cong, Cai, Wang-Yu, Zhang, Wei, Long, Ying, Zeng, Yong, Ye, Guo-Dong, Yang, Shu-Yu
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 15.09.2017
• Subjects: Research Paper; aldose reductase; AKT/mTOR signaling; hepatocellular carcinoma
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.17791

Marked up-regulation of aldose reductase (AR) is reportedly associated with the development of hepatocellular carcinoma (HCC). We investigated how aberrantly overexpressed AR might promote oncogenic transformation in liver cells and tissues. We found that overexpressed AR interacted with the kinase...