p53/Drp1-dependent mitochondrial fission mediates aldosterone-induced podocyte injury and mitochondrial dysfunction

• Published in: American journal of physiology. Renal physiology Vol. 314; no. 5; pp. F798 - F808
• Main Authors: Yuan, Yanggang, Zhang, Aiqing, Qi, Jia, Wang, Hui, Liu, Xi, Zhao, Min, Duan, Suyan, Huang, Zhimin, Zhang, Chengning, Wu, Lin, Zhang, Bo, Zhang, Aihua, Xing, Changying
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2018
• Subjects: Aldosterone; Aldosterone - administration & dosage; Aldosterone - toxicity; Animals; Apoptosis; Apoptosis - drug effects; Cell Line; Dose-Response Relationship, Drug; Dynamin; Dynamins - genetics; Dynamins - metabolism; Infusions, Subcutaneous; Kidney Diseases - chemically induced; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Male; Mice, Inbred C57BL; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Dynamics - drug effects; Nephropathy; p53 Protein; Podocytes - drug effects; Podocytes - metabolism; Podocytes - pathology; Proteins; Quinazolinones - pharmacology; Signal Transduction - drug effects; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; mitochondrial fission; podocyte injury; aldosterone; Drp1; p53

Mitochondrial dysfunction is increasingly recognized as an important factor in glomerular diseases. Previous study has shown that mitochondrial fission contributed to mitochondrial dysfunction. However, the mechanism of mitochondrial fission on mitochondrial dysfunction in aldosterone-induced podocy...