p53/Drp1-dependent mitochondrial fission mediates aldosterone-induced podocyte injury and mitochondrial dysfunction - Yuan, Yanggang; Zhang, Aiqing; Qi, Jia; Wang, Hui; Liu, Xi; Zhao, Min; Duan, Suyan; Huang, Zhimin; Zhang, Chengning; Wu, Lin; Zhang, Bo; Zhang, Aihua; et al. (American journal of physiology. Renal physiology, 2018)
Keywords: Aldosterone; Aldosterone - administration & dosage; Aldosterone - toxicity; Animals; Apoptosis; Apoptosis - drug effects; Cell Line; Dose-Response Relationship, Drug; Dynamin; Dynamins - genetics; Dynamins - metabolism; Infusions, Subcutaneous; Kidney Diseases - chemically induced; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Male; Mice, Inbred C57BL; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Dynamics - drug effects; Nephropathy; p53 Protein; Podocytes - drug effects; Podocytes - metabolism; Podocytes - pathology; Proteins; Quinazolinones - pharmacology; Signal Transduction - drug effects; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; mitochondrial fission; podocyte injury; aldosterone; Drp1; p53