Clinical significance of total nucleated cell count in bone marrow of patients with acute lymphoblastic leukemia who underwent allogeneic hematopoietic stem cell transplantation

• Published in: International journal of hematology Vol. 119; no. 1; pp. 62 - 70
• Main Authors: Nukui, Jun, Tachibana, Takayoshi, Miyazaki, Takuya, Tanaka, Masatsugu, Matsumoto, Kenji, Ishii, Yoshimi, Numata, Ayumi, Nakajima, Yuki, Matsumura, Ayako, Suzuki, Taisei, Izumi, Akihiko, Hirose, Natsuki, Yamamoto, Koji, Hagihara, Maki, Fujisawa, Shin, Kanamori, Heiwa, Nakajima, Hideaki
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.01.2024; Springer Nature B.V
• Subjects: Acute lymphoblastic leukemia; Allografts; Antigens; Bone Marrow; Clinical Relevance; Clinical significance; Comorbidity; Graft versus host disease; Hematology; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Humans; Leukemia; Leukocytes; Lymphatic leukemia; Medicine; Medicine & Public Health; Mortality; Oncology; Original Article; Patients; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Recurrence; Remission; Remission (Medicine); Retrospective Studies; Stem cell transplantation; Stem cells; Transplantation; Acute lymphoblastic leukemia; Nucleated cell count; Allogeneic hematopoietic stem cell transplantation
• ISSN: 0925-5710; 1865-3774; 1865-3774
• DOI: 10.1007/s12185-023-03688-7

The clinical implications of recipient bone marrow nucleated cell count (NCC) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unknown. We conducted a multicenter retrospective study to evaluate the clinical significance of bone marrow NCC prior to allo-HSCT in patients with acute lymphoblastic leukemia. Patients who were in remission and underwent the initial allo-HSCT were included and stratified into high- and low-NCC groups using an NCC of 10 × 10 4 /µL as the cut-off. The 3-year overall survival (OS), non-relapse mortality (NRM), and relapse rates for the high- and low-NCC groups were 51.2 vs. 84.5% ( p  < 0.001), 27.5 vs. 6.5% ( p  < 0.001), and 31.1 vs. 24.4% ( p  = 0.322), respectively. The high-NCC group had significantly poorer OS and higher NRM when compared with the low-NCC group. In summary, high recipient bone marrow NCC is associated with higher NRM and lower OS following allo-HSCT.