Inhibition of MSTN signal pathway may participate in LIPUS preventing bone loss in ovariectomized rats

• Published in: Journal of bone and mineral metabolism Vol. 38; no. 1; pp. 14 - 26
• Main Authors: Tang, Liang, Kang, Yiting, Sun, Shuxin, Zhao, Tingting, Cao, Wenxin, Fan, Xiushan, Guo, Jianzhong, Sun, Lijun, Ta, Dean
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.01.2020; Springer Nature B.V
• Subjects: Alkaline Phosphatase - blood; Animals; Biomechanical Phenomena; Body Weight; Bone growth; Bone healing; Bone loss; Bone Resorption - blood; Bone Resorption - prevention & control; Female; Femur; Femur - diagnostic imaging; Femur - physiology; Fractures; Gene Expression Regulation; Mechanical properties; Medicine; Medicine & Public Health; Metabolic Diseases; Molecular modelling; Muscle Fibers, Skeletal - pathology; Muscles - pathology; Myostatin - metabolism; Organ Size; Original Article; Orthopedics; Osteogenesis; Osteoporosis; Ovariectomy; Quadriceps muscle; Rats, Sprague-Dawley; Signal Transduction; Skeletal muscle; Tartrate-Resistant Acid Phosphatase - blood; Transforming growth factor-b; Ultrasonic Waves; Uterus - pathology; Wnt protein; Wnt Signaling Pathway; Osteoporosis; Myostatin; Bone defect healing; Bone microstructure; Low-intensity pulsed ultrasound

Introduction Menopause can lead to osteoporosis, which is characterized by destruction of bone microstructure, poor mechanical properties, and prone to fracture. LIPUS can effectively promote bone formation and fracture healing. MSTN is a transforming growth factor-β family member that acts as a neg...