DNA Hypermethylation of Promoter of Gene p53 and p16 in Arsenic-Exposed People with and without Malignancy

• Published in: Toxicological sciences Vol. 89; no. 2; pp. 431 - 437
• Main Authors: Chanda, Sarmishtha, Dasgupta, Uma B., GuhaMazumder, Debendranath, Gupta, Mausumi, Chaudhuri, Utpal, Lahiri, Sarbari, Das, Subhankar, Ghosh, Nilima, Chatterjee, Debdutta
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2006
• Subjects: Adolescent; Adult; arsenic; Arsenic - toxicity; Arsenic Poisoning - etiology; Arsenic Poisoning - genetics; Arsenic Poisoning - metabolism; cancer; DNA; DNA Methylation - drug effects; Female; Genes, p16; Genes, p53; Genes, Tumor Suppressor; Humans; hypermethylation; hypomethylation; Male; Middle Aged; Promoter Regions, Genetic; Skin Neoplasms - chemically induced; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Water Pollutants, Chemical - toxicity

Chronic arsenic exposure is known to produce arsenicosis and cancer. To ascertain whether perturbation of methylation plays a role in such carcinogenesis, the degree of methylation of p53 and p16 gene in DNA obtained from blood samples of people chronically exposed to arsenic and skin cancer subject...