Ketamine anesthesia helps preserve neuronal viability

The dissociative anesthetic ketamine that acts as an N-methyl-D-aspartate (NMDA) antagonist has been reported to improve neurological damage after experimental ischemic challenges. Here we show that deep anesthesia with ketamine before euthanasia by decapitation improves the quality of neonatal mous...

Full description

Saved in:
Bibliographic Details
Published inJournal of neuroscience methods Vol. 189; no. 2; pp. 230 - 232
Main Authors de Oliveira, Ramatis B., Graham, Brett, Howlett, Marcus C.H., Gravina, Fernanda S., Oliveira, Max W.S., Imtiaz, Mohammad S., Callister, Robert J., Lim, Rebecca, Brichta, Alan M., van Helden, Dirk F.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.06.2010
Subjects
Anesthesia
Anesthetics, Dissociative - administration & dosage
Anesthetics, Dissociative - pharmacology
Animals
Animals, Newborn
Cell Survival
Electric Capacitance
Electric Impedance
Electrophysiological properties
Hypoglossal motor neurons
Hypoglossal Nerve - drug effects
Hypoglossal Nerve - physiology
In Vitro Techniques
Input resistance
Ketamine
Ketamine - administration & dosage
Ketamine - pharmacology
Locus coeruleus
Locus Coeruleus - drug effects
Locus Coeruleus - physiology
Membrane Potentials - drug effects
Mice
Motor Neurons - drug effects
Motor Neurons - physiology
Neurons - drug effects
Neurons - physiology
Organ Preservation - methods
Patch-Clamp Techniques
Tissue and Organ Harvesting - methods
Viability
Input resistance
Ketamine
Hypoglossal motor neurons
Viability
Electrophysiological properties
Locus coeruleus
Online AccessGet full text

Cover

Abstract The dissociative anesthetic ketamine that acts as an N-methyl-D-aspartate (NMDA) antagonist has been reported to improve neurological damage after experimental ischemic challenges. Here we show that deep anesthesia with ketamine before euthanasia by decapitation improves the quality of neonatal mouse neuronal brain slice preparations. Specifically we found that neurons of the locus coeruleus (LC) and hypoglossal motor neurons had significantly higher input resistances, and LC neurons that generally are difficult to voltage control, could be more reliably voltage clamped compared to control neurons.
AbstractList The dissociative anesthetic ketamine that acts as an N-methyl-D-aspartate (NMDA) antagonist has been reported to improve neurological damage after experimental ischemic challenges. Here we show that deep anesthesia with ketamine before euthanasia by decapitation improves the quality of neonatal mouse neuronal brain slice preparations. Specifically we found that neurons of the locus coeruleus (LC) and hypoglossal motor neurons had significantly higher input resistances, and LC neurons that generally are difficult to voltage control, could be more reliably voltage clamped compared to control neurons.
The dissociative anesthetic ketamine that acts as an N-methyl-D-aspartate (NMDA) antagonist has been reported to improve neurological damage after experimental ischemic challenges. Here we show that deep anesthesia with ketamine before euthanasia by decapitation improves the quality of neonatal mouse neuronal brain slice preparations. Specifically we found that neurons of the locus coeruleus (LC) and hypoglossal motor neurons had significantly higher input resistances, and LC neurons that generally are difficult to voltage control, could be more reliably voltage clamped compared to control neurons.
Author Graham, Brett
Lim, Rebecca
Oliveira, Max W.S.
van Helden, Dirk F.
Howlett, Marcus C.H.
Gravina, Fernanda S.
Callister, Robert J.
de Oliveira, Ramatis B.
Imtiaz, Mohammad S.
Brichta, Alan M.
Author_xml – sequence: 1
  givenname: Ramatis B.
  surname: de Oliveira
  fullname: de Oliveira, Ramatis B.
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 2
  givenname: Brett
  surname: Graham
  fullname: Graham, Brett
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 3
  givenname: Marcus C.H.
  surname: Howlett
  fullname: Howlett, Marcus C.H.
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 4
  givenname: Fernanda S.
  surname: Gravina
  fullname: Gravina, Fernanda S.
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 5
  givenname: Max W.S.
  surname: Oliveira
  fullname: Oliveira, Max W.S.
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 6
  givenname: Mohammad S.
  surname: Imtiaz
  fullname: Imtiaz, Mohammad S.
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 7
  givenname: Robert J.
  surname: Callister
  fullname: Callister, Robert J.
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 8
  givenname: Rebecca
  surname: Lim
  fullname: Lim, Rebecca
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 9
  givenname: Alan M.
  surname: Brichta
  fullname: Brichta, Alan M.
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
– sequence: 10
  givenname: Dirk F.
  surname: van Helden
  fullname: van Helden, Dirk F.
  email: dirk.vanhelden@newcastle.edu.au
  organization: School of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Newcastle, NSW 2308, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20380852$$D View this record in MEDLINE/PubMed
BookMark eNqFkE1LAzEQhoNUbKv-Bdmbp62Tj2aTm1L8woIXBW8hzc7SlP2oyW6h_96UqteeBobnnXd4pmTUdi0SckNhRoHKu81s0-LQYL-eMUhL4DNg-oxMqCpYLgv1NSKTBM5zYAWMyTTGDQAIDfKCjBlwBWrOJmT-hr1tfIuZbTH2a4zeZmustzHbBowYdpilotC1ts523q587fv9FTmvbB3x-ndeks-nx4_FS758f35dPCxzx7Xuc1FZxZyzVConNafAS7UCrJzVVgtqNReUFZxLZp0rlVgJOa8kt45qh8xV_JLcHu9uQ_c9pP9M46PDuk7PdkM0qtCiKDRlJ8nUQpnQ4kDKI-lCF2PAymyDb2zYGwrm4NZszJ9bc3BrgJvkNgVvfiuGVYPlf-xPZgLujwAmJTuPwUTnsXVY-oCuN2XnT3X8AFAHj_8
CitedBy_id crossref_primary_10_1016_j_brainres_2011_09_053
crossref_primary_10_1111_jnc_14692
crossref_primary_10_1016_j_arcped_2012_11_004
crossref_primary_10_1152_jn_00016_2022
crossref_primary_10_1016_j_neuroscience_2010_06_028
crossref_primary_10_1152_jn_00030_2017
crossref_primary_10_1007_s00726_014_1910_0
crossref_primary_10_1155_2012_820285
crossref_primary_10_1113_jphysiol_2012_227389
crossref_primary_10_1042_CS20210792
crossref_primary_10_1016_j_lfs_2021_119916
Cites_doi 10.1016/S0893-133X(98)00067-0
10.1080/0001648031000692
10.1007/BF03018950
10.1213/01.ANE.0000160585.43587.5B
10.1016/0304-3959(94)00170-J
10.1213/00000539-196005000-00015
10.1097/JCP.0b013e31819a4b91
10.1016/S0006-3223(99)00140-7
10.1016/0006-8993(76)90236-5
10.1523/JNEUROSCI.3991-05.2006
10.1016/S0006-3223(99)00230-9
10.1038/sj.bjp.0706385
10.1007/s00213-006-0572-3
ContentType Journal Article
Copyright 2010 Elsevier B.V.
Copyright (c) 2010 Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2010 Elsevier B.V.
– notice: Copyright (c) 2010 Elsevier B.V. All rights reserved.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
7TK
DOI 10.1016/j.jneumeth.2010.03.029
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Neurosciences Abstracts
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
Neurosciences Abstracts
DatabaseTitleList Neurosciences Abstracts
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
EISSN 1872-678X
EndPage 232
ExternalDocumentID 10_1016_j_jneumeth_2010_03_029
20380852
S0165027010001846
Genre Journal Article
GroupedDBID ---
--K
--M
-~X
.55
.GJ
.~1
0R~
1B1
1RT
1~.
1~5
29L
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
71M
8P~
9JM
AABNK
AACTN
AADPK
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AAXLA
AAXUO
ABCQJ
ABFNM
ABFRF
ABJNI
ABMAC
ABXDB
ABYKQ
ACDAQ
ACGFO
ACGFS
ACIUM
ACRLP
ADBBV
ADEZE
ADMUD
AEBSH
AEFWE
AEKER
AENEX
AFKWA
AFTJW
AFXIZ
AGHFR
AGUBO
AGWIK
AGYEJ
AHHHB
AHPSJ
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HMQ
HVGLF
HZ~
IHE
J1W
K-O
KOM
L7B
M2V
M41
MO0
MOBAO
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SDF
SDG
SDP
SES
SEW
SNS
SPCBC
SSN
SSZ
T5K
WUQ
X7M
ZGI
~G-
AAXKI
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
AFJKZ
CITATION
7X8
7TK
ID FETCH-LOGICAL-c399t-4fa82cca168c693103d8b0efca9a941a9341273362accd84b465f63ac19ce2cf3
IEDL.DBID AIKHN
ISSN 0165-0270
IngestDate Fri Aug 16 09:38:45 EDT 2024
Fri Aug 16 04:21:52 EDT 2024
Thu Sep 26 15:36:39 EDT 2024
Sat Sep 28 08:14:07 EDT 2024
Fri Feb 23 02:33:24 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Input resistance
Ketamine
Hypoglossal motor neurons
Viability
Electrophysiological properties
Locus coeruleus
Language English
License Copyright (c) 2010 Elsevier B.V. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c399t-4fa82cca168c693103d8b0efca9a941a9341273362accd84b465f63ac19ce2cf3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
PMID 20380852
PQID 733124942
PQPubID 23479
PageCount 3
ParticipantIDs proquest_miscellaneous_879477912
proquest_miscellaneous_733124942
crossref_primary_10_1016_j_jneumeth_2010_03_029
pubmed_primary_20380852
elsevier_sciencedirect_doi_10_1016_j_jneumeth_2010_03_029
PublicationCentury 2000
PublicationDate 2010-06-15
PublicationDateYYYYMMDD 2010-06-15
PublicationDate_xml – month: 06
  year: 2010
  text: 2010-06-15
  day: 15
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Journal of neuroscience methods
PublicationTitleAlternate J Neurosci Methods
PublicationYear 2010
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Collins, Gorospe, Rovenstine (bib4) 1960; 39
Stefanovic, Brandner, Klaassen, Cregg, Nagaratnam, Bromley (bib13) 2009; 29
Aston-Jones, Rajkowski, Cohen (bib1) 1999; 46
Schnoebel, Wolff, Peters, Brau, Scholz, Hempelmann (bib12) 2005; 146
Leong, Puil, Schwarz (bib7) 2004; 124
Mathisen, Skjelbred, Skoglund, Oye (bib8) 1995; 61
Morgan, Curran (bib9) 2006; 188
Himmelseher, Durieux (bib6) 2005; 101
Graham, Schofield, Sah, Margrie, Callister (bib5) 2006; 26
Bergman (bib2) 1999; 46
Reeker, Werner, Mollenberg, Mielke, Kochs (bib11) 2000; 47
Berman, Cappiello, Anand, Oren, Heninger, Charney (bib3) 2000; 47
Ward, Gunn (bib14) 1976; 107
Newcomer, Farber, Jevtovic-Todorovic, Selke, Melson, Hershey (bib10) 1999; 20
Morgan (10.1016/j.jneumeth.2010.03.029_bib9) 2006; 188
Ward (10.1016/j.jneumeth.2010.03.029_bib14) 1976; 107
Mathisen (10.1016/j.jneumeth.2010.03.029_bib8) 1995; 61
Himmelseher (10.1016/j.jneumeth.2010.03.029_bib6) 2005; 101
Newcomer (10.1016/j.jneumeth.2010.03.029_bib10) 1999; 20
Leong (10.1016/j.jneumeth.2010.03.029_bib7) 2004; 124
Reeker (10.1016/j.jneumeth.2010.03.029_bib11) 2000; 47
Graham (10.1016/j.jneumeth.2010.03.029_bib5) 2006; 26
Aston-Jones (10.1016/j.jneumeth.2010.03.029_bib1) 1999; 46
Berman (10.1016/j.jneumeth.2010.03.029_bib3) 2000; 47
Schnoebel (10.1016/j.jneumeth.2010.03.029_bib12) 2005; 146
Collins (10.1016/j.jneumeth.2010.03.029_bib4) 1960; 39
Stefanovic (10.1016/j.jneumeth.2010.03.029_bib13) 2009; 29
Bergman (10.1016/j.jneumeth.2010.03.029_bib2) 1999; 46
References_xml – volume: 26
  start-page: 4880
  year: 2006
  end-page: 4890
  ident: bib5
  article-title: Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator
  publication-title: J Neurosci
  contributor:
    fullname: Callister
– volume: 20
  start-page: 106
  year: 1999
  end-page: 118
  ident: bib10
  article-title: Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis
  publication-title: Neuropsychopharmacology
  contributor:
    fullname: Hershey
– volume: 107
  start-page: 401
  year: 1976
  end-page: 406
  ident: bib14
  article-title: Locus coeruleus complex: elicitation of a pressor response and a brain stem region necessary for its occurrence
  publication-title: Brain Res
  contributor:
    fullname: Gunn
– volume: 46
  start-page: 10
  year: 1999
  end-page: 20
  ident: bib2
  article-title: Ketamine: review of its pharmacology and its use in pediatric anesthesia
  publication-title: Anesth Prog
  contributor:
    fullname: Bergman
– volume: 46
  start-page: 1309
  year: 1999
  end-page: 1320
  ident: bib1
  article-title: Role of locus coeruleus in attention and behavioral flexibility
  publication-title: Biol Psychiatry
  contributor:
    fullname: Cohen
– volume: 39
  start-page: 302
  year: 1960
  end-page: 306
  ident: bib4
  article-title: Intravenous nonbarbiturate, nonnarcotic analgesics: preliminary studies. 1. Cyclohexylamines
  publication-title: Anesth Analg
  contributor:
    fullname: Rovenstine
– volume: 47
  start-page: 572
  year: 2000
  end-page: 578
  ident: bib11
  article-title: High-dose S(+)-ketamine improves neurological outcome following incomplete cerebral ischemia in rats
  publication-title: Can J Anaesth
  contributor:
    fullname: Kochs
– volume: 101
  start-page: 524
  year: 2005
  end-page: 534
  ident: bib6
  article-title: Revising a dogma: ketamine for patients with neurological injury?
  publication-title: Anesth Analg
  contributor:
    fullname: Durieux
– volume: 29
  start-page: 124
  year: 2009
  end-page: 133
  ident: bib13
  article-title: Acute and chronic effects of ketamine on semantic priming: modeling schizophrenia?
  publication-title: J Clin Psychopharmacol
  contributor:
    fullname: Bromley
– volume: 61
  start-page: 215
  year: 1995
  end-page: 220
  ident: bib8
  article-title: Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain
  publication-title: Pain
  contributor:
    fullname: Oye
– volume: 146
  start-page: 826
  year: 2005
  end-page: 833
  ident: bib12
  article-title: Ketamine impairs excitability in superficial dorsal horn neurones by blocking sodium and voltage-gated potassium currents
  publication-title: Br J Pharmacol
  contributor:
    fullname: Hempelmann
– volume: 124
  start-page: 454
  year: 2004
  end-page: 458
  ident: bib7
  article-title: Ketamine blocks non-N-methyl-D-aspartate receptor channels attenuating glutamatergic transmission in the auditory cortex
  publication-title: Acta Otolaryngol
  contributor:
    fullname: Schwarz
– volume: 188
  start-page: 408
  year: 2006
  end-page: 424
  ident: bib9
  article-title: Acute and chronic effects of ketamine upon human memory: a review
  publication-title: Psychopharmacology (Berl)
  contributor:
    fullname: Curran
– volume: 47
  start-page: 351
  year: 2000
  end-page: 354
  ident: bib3
  article-title: Antidepressant effects of ketamine in depressed patients
  publication-title: Biol Psychiatry
  contributor:
    fullname: Charney
– volume: 20
  start-page: 106
  year: 1999
  ident: 10.1016/j.jneumeth.2010.03.029_bib10
  article-title: Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis
  publication-title: Neuropsychopharmacology
  doi: 10.1016/S0893-133X(98)00067-0
  contributor:
    fullname: Newcomer
– volume: 124
  start-page: 454
  year: 2004
  ident: 10.1016/j.jneumeth.2010.03.029_bib7
  article-title: Ketamine blocks non-N-methyl-D-aspartate receptor channels attenuating glutamatergic transmission in the auditory cortex
  publication-title: Acta Otolaryngol
  doi: 10.1080/0001648031000692
  contributor:
    fullname: Leong
– volume: 47
  start-page: 572
  year: 2000
  ident: 10.1016/j.jneumeth.2010.03.029_bib11
  article-title: High-dose S(+)-ketamine improves neurological outcome following incomplete cerebral ischemia in rats
  publication-title: Can J Anaesth
  doi: 10.1007/BF03018950
  contributor:
    fullname: Reeker
– volume: 101
  start-page: 524
  year: 2005
  ident: 10.1016/j.jneumeth.2010.03.029_bib6
  article-title: Revising a dogma: ketamine for patients with neurological injury?
  publication-title: Anesth Analg
  doi: 10.1213/01.ANE.0000160585.43587.5B
  contributor:
    fullname: Himmelseher
– volume: 61
  start-page: 215
  year: 1995
  ident: 10.1016/j.jneumeth.2010.03.029_bib8
  article-title: Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain
  publication-title: Pain
  doi: 10.1016/0304-3959(94)00170-J
  contributor:
    fullname: Mathisen
– volume: 39
  start-page: 302
  year: 1960
  ident: 10.1016/j.jneumeth.2010.03.029_bib4
  article-title: Intravenous nonbarbiturate, nonnarcotic analgesics: preliminary studies. 1. Cyclohexylamines
  publication-title: Anesth Analg
  doi: 10.1213/00000539-196005000-00015
  contributor:
    fullname: Collins
– volume: 29
  start-page: 124
  year: 2009
  ident: 10.1016/j.jneumeth.2010.03.029_bib13
  article-title: Acute and chronic effects of ketamine on semantic priming: modeling schizophrenia?
  publication-title: J Clin Psychopharmacol
  doi: 10.1097/JCP.0b013e31819a4b91
  contributor:
    fullname: Stefanovic
– volume: 46
  start-page: 1309
  year: 1999
  ident: 10.1016/j.jneumeth.2010.03.029_bib1
  article-title: Role of locus coeruleus in attention and behavioral flexibility
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(99)00140-7
  contributor:
    fullname: Aston-Jones
– volume: 107
  start-page: 401
  year: 1976
  ident: 10.1016/j.jneumeth.2010.03.029_bib14
  article-title: Locus coeruleus complex: elicitation of a pressor response and a brain stem region necessary for its occurrence
  publication-title: Brain Res
  doi: 10.1016/0006-8993(76)90236-5
  contributor:
    fullname: Ward
– volume: 26
  start-page: 4880
  year: 2006
  ident: 10.1016/j.jneumeth.2010.03.029_bib5
  article-title: Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3991-05.2006
  contributor:
    fullname: Graham
– volume: 46
  start-page: 10
  year: 1999
  ident: 10.1016/j.jneumeth.2010.03.029_bib2
  article-title: Ketamine: review of its pharmacology and its use in pediatric anesthesia
  publication-title: Anesth Prog
  contributor:
    fullname: Bergman
– volume: 47
  start-page: 351
  year: 2000
  ident: 10.1016/j.jneumeth.2010.03.029_bib3
  article-title: Antidepressant effects of ketamine in depressed patients
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(99)00230-9
  contributor:
    fullname: Berman
– volume: 146
  start-page: 826
  year: 2005
  ident: 10.1016/j.jneumeth.2010.03.029_bib12
  article-title: Ketamine impairs excitability in superficial dorsal horn neurones by blocking sodium and voltage-gated potassium currents
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0706385
  contributor:
    fullname: Schnoebel
– volume: 188
  start-page: 408
  year: 2006
  ident: 10.1016/j.jneumeth.2010.03.029_bib9
  article-title: Acute and chronic effects of ketamine upon human memory: a review
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s00213-006-0572-3
  contributor:
    fullname: Morgan
SSID ssj0004906
Score 2.0485566
Snippet The dissociative anesthetic ketamine that acts as an N-methyl-D-aspartate (NMDA) antagonist has been reported to improve neurological damage after experimental...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 230
SubjectTerms Anesthesia
Anesthetics, Dissociative - administration & dosage
Anesthetics, Dissociative - pharmacology
Animals
Animals, Newborn
Cell Survival
Electric Capacitance
Electric Impedance
Electrophysiological properties
Hypoglossal motor neurons
Hypoglossal Nerve - drug effects
Hypoglossal Nerve - physiology
In Vitro Techniques
Input resistance
Ketamine
Ketamine - administration & dosage
Ketamine - pharmacology
Locus coeruleus
Locus Coeruleus - drug effects
Locus Coeruleus - physiology
Membrane Potentials - drug effects
Mice
Motor Neurons - drug effects
Motor Neurons - physiology
Neurons - drug effects
Neurons - physiology
Organ Preservation - methods
Patch-Clamp Techniques
Tissue and Organ Harvesting - methods
Viability
Title Ketamine anesthesia helps preserve neuronal viability
URI https://dx.doi.org/10.1016/j.jneumeth.2010.03.029
https://www.ncbi.nlm.nih.gov/pubmed/20380852
https://search.proquest.com/docview/733124942
https://search.proquest.com/docview/879477912
Volume 189
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NS8MwFH_oBPEi6vyYX-Qg3rq1aZo0xyGO6dguKuwW0izFDdcNtwle_Nt96YcfoHjw1pY0hN9r3_u95H0AXISaCiFs4kXGph5LGfN0QoXnsxHX3KAjZF2Cc3_Auw_sdhgN1-CqyoVxYZWl7i90eq6tyyetEs3WfDxu3blEHJzLdzvU6KfwddhAc8RYDTbaN73u4DM9UuYtNt14d2Tpf0kUnjQnmV25Zs1llFfY9HO2-aON-o2D5raoswPbJYkk7WKdu7Bmsz2otzN0oKev5JLkYZ35fvkebPbL0_M6RD271FO8JBoVHDK_xViTR_s0XxAXDutiH0le39JN_jIuKni_7sND5_r-quuVbRM8g2xjiYDrmKJgAh4bLl0fsVGc-DY1WmrJAi3RcFFXBZFqY0YxSxiPUh5qE0hjqUnDA6hls8weAeFhgKaN8URGljE5SoQUxiZ4zwPrC9GAVgWUmhfVMVQVNjZRFbTKQav8UCG0DZAVnuqbnBWq8D_fJZUAFP4E7mQD4ZqtFso1nkQ_ktHfh8SoeISQAQ45LGT3sWLqhzEyT3r8j7WdwFYRV8C9IDqF2vJ5Zc-QriyTc1hvvgXn5Uf5DtWi6YM
link.rule.ids 315,786,790,4521,24144,27957,27958,45620,45714
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9swED9BJ429IMbH1gGbH9De0iaOY8ePqAKVlfICSLxZjuuIVjSt1hapL_ztu8sHA2loD7wlkWNZd8nd7-zf3QGcxJYrpXwWJM7ngciFCGzGVRCKkbTSYSDkKcF5eCX7t-LXXXK3Ab0mF4ZolbXtr2x6aa3rJ91amt35eNy9pkQcnCukHWqMU-QmfCA4T_0bOk9_eR5Clw02aTQdWIYv0oQnnUnhV9SqueZ4xZ2wxJr_9FBvIdDSE53vwHYNIdlptcrPsOGLXdg7LTB8nq7ZT1aSOsvd8l34OKzPzvcgGfilneIls2jeEPctxpbd-4f5ghEZlpiPrKxuSZM_jqv63et9uD0_u-n1g7ppQuAQayxR3DblqJZIpk5q6iI2SrPQ585qq0VkNbotTjUQuXVulIpMyCSXsXWRdp67PD6AVjEr_FdgMo7QsQmZ6cQLoUeZ0sr5DO9l5EOl2tBtBGXmVW0M05DGJqYRrSHRmjA2KNo26Eae5pWWDRrw_77LGgUY_AXoXAPFNVstDLWdxChS8LeHpGh2lNIRDvlS6e55xTyMU8Sd_Ns71vYDtvo3w0tzeXE1OIRPFcNABlFyBK3l75U_RuCyzL6XH-Yf1PjqUQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Ketamine+anesthesia+helps+preserve+neuronal+viability&rft.jtitle=Journal+of+neuroscience+methods&rft.au=de+Oliveira%2C+Ramatis+B&rft.au=Graham%2C+Brett&rft.au=Howlett%2C+Marcus+C+H&rft.au=Gravina%2C+Fernanda+S&rft.date=2010-06-15&rft.eissn=1872-678X&rft.volume=189&rft.issue=2&rft.spage=230&rft.epage=232&rft_id=info:doi/10.1016%2Fj.jneumeth.2010.03.029&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0165-0270&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0165-0270&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0165-0270&client=summon