Combined-Modality Therapy Versus Radiotherapy Alone for Treatment of Early-Stage Hodgkin's Disease: Cure Balanced Against Complications

• Published in: Journal of clinical oncology Vol. 24; no. 4; pp. 605 - 611
• Main Authors: KOONTZ, Bridget F, KIRKPATRICK, John P, CLOUGH, Robert W, PROSNITZ, Robert G, GOCKERMAN, Jon P, MOORE, Joseph O, PROSNITZ, Leonard R
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 01.02.2006; Lippincott Williams & Wilkins
• Subjects: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Cause of Death; Chemotherapy, Adjuvant - adverse effects; Child; Child, Preschool; Coronary Disease - epidemiology; Coronary Disease - etiology; Coronary Disease - prevention & control; Disease-Free Survival; Female; Hematologic and hematopoietic diseases; Hodgkin Disease - drug therapy; Hodgkin Disease - pathology; Hodgkin Disease - radiotherapy; Humans; Incidence; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Nodes - radiation effects; Male; Medical sciences; Middle Aged; Neoplasm Staging; Neoplasms, Radiation-Induced - epidemiology; Neoplasms, Radiation-Induced - etiology; Neoplasms, Radiation-Induced - prevention & control; Radiotherapy Dosage; Radiotherapy, Adjuvant - adverse effects; Retrospective Studies; Risk Assessment; Survival Analysis; Tumors; Clinical stage; Cancerology; Cure; Lymphoproliferative syndrome; Complication; Hodgkin disease; Early stage; Malignant hemopathy; Combined treatment; Lymphoma; Comparative study

The treatment of early-stage Hodgkin's disease (HD) has evolved from radiotherapy alone (RT) to combined-modality therapy (CMT) because of concerns about late adverse effects from high-dose subtotal nodal irradiation (STNI). However, there is little information regarding the long-term results o...