Assessment of wasted myocardial work: a novel method to quantify energy loss due to uncoordinated left ventricular contractions

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 305; no. 7; pp. H996 - H1003
• Main Authors: Russell, Kristoffer, Eriksen, Morten, Aaberge, Lars, Wilhelmsen, Nils, Skulstad, Helge, Gjesdal, Ola, Edvardsen, Thor, Smiseth, Otto A.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2013
• Subjects: Aged; Animals; Biomechanical Phenomena; Bundle-Branch Block - diagnosis; Bundle-Branch Block - metabolism; Bundle-Branch Block - physiopathology; Cardiac Resynchronization Therapy; Cardiovascular disease; Correlation analysis; Disease Models, Animal; Dogs; Energy; Energy Metabolism; Female; Heart Failure - diagnosis; Heart Failure - metabolism; Heart Failure - physiopathology; Heart Failure - therapy; Humans; Male; Middle Aged; Models, Cardiovascular; Myocardial Contraction; Myocardium - metabolism; Strain rate; Time Factors; Ultrasonic imaging; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - metabolism; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - therapy; Ventricular Function, Left; Ventricular Pressure; heart failure; dyssynchrony; cardiac resynchronization therapy; myocardial function

Left ventricular (LV) dyssynchrony reduces myocardial efficiency because work performed by one segment is wasted by stretching other segments. In the present study, we introduce a novel noninvasive clinical method that quantifies wasted energy as the ratio between work consumed during segmental leng...