The preparation and biological characterization of a new HL91-derivative for hypoxic imaging on stroke mice

• Published in: Applied radiation and isotopes Vol. 68; no. 9; pp. 1610 - 1615
• Main Authors: Hsia, Chien-Chung, Huang, Fu-Lei, Lin, Cheng-Hsien, Shen, Lie-Hang, Wang, Hsin-Ell
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2010
• Subjects: Animals; Brain - diagnostic imaging; HL91; Hypoxia; Hypoxia, Brain - complications; Hypoxia, Brain - diagnostic imaging; Isotope Labeling - methods; Mice; Mice, Inbred BALB C; Organotechnetium Compounds - chemical synthesis; Oximes - chemical synthesis; Radiopharmaceuticals - chemical synthesis; Stroke; Stroke - diagnostic imaging; Stroke - etiology; Tomography, Emission-Computed, Single-Photon - methods; Hypoxia; HL91; Stroke

99mTc-HL91 (Prognox, GE-Healthcare) was the first nonnitro-aryl-based radiotracer for evaluating hypoxic fraction in neoplasm, stroke and myocardium infarction regions. However, the high hydrophilicity of 99mTc-HL91 might hamper its penetration into cells. In this study, we prepared a new ligand 4,4...