Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers
In this study, double-hydrophilic hydroxylpropyl cellulose （HPC） based copolymers with poly（N- isopropylacrylamide） （PNIPAM） and poly（acrylic acid） （PAA） as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophili...
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| Published in | Chinese journal of chemical engineering Vol. 17; no. 1; pp. 145 - 149 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.02.2009
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1004-9541 2210-321X |
| DOI | 10.1016/S1004-9541(09)60046-X |
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| Abstract | In this study, double-hydrophilic hydroxylpropyl cellulose （HPC） based copolymers with poly（N- isopropylacrylamide） （PNIPAM） and poly（acrylic acid） （PAA） as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. It shows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process. |
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| AbstractList | In this study, double-hydrophilic hydroxylpropyl cellulose (HPC) based copolymers with poly(Nisopropylacrylamide) (PNIPAM) and poly(acrylic acid) (PAA) as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. Itshows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process. In this study, double-hydrophilic hydroxylpropyl cellulose （HPC） based copolymers with poly（N- isopropylacrylamide） （PNIPAM） and poly（acrylic acid） （PAA） as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. It shows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process. In this study, double-hydrophilic hydroxylpropyl cellulose (HPC) based copolymers with poly(Nisopropylacrylamide) (PNIPAM) and poly(acrylic acid) (PAA) as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. Itshows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process. |
| Author | 李小军 尹明辉 张国亮 张凤宝 |
| AuthorAffiliation | School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China |
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| CitedBy_id | crossref_primary_10_1007_s00396_011_2423_y crossref_primary_10_1016_j_cjche_2014_06_030 crossref_primary_10_1016_j_colsurfb_2013_09_027 crossref_primary_10_4028_www_scientific_net_AMR_671_674_868 crossref_primary_10_1039_C0PY00417K crossref_primary_10_1134_S1560090413070063 crossref_primary_10_1080_01932691_2017_1339608 crossref_primary_10_1016_j_carbpol_2017_10_067 crossref_primary_10_1080_00914030903538637 |
| Cites_doi | 10.1016/S0144-8617(99)00101-0 10.1038/373049a0 10.1016/j.polymer.2006.09.017 10.1016/j.ejpb.2007.01.012 10.1016/j.ejpb.2004.02.016 10.1016/j.jcis.2007.05.027 10.1016/j.reactfunctpolym.2006.01.012 10.1016/S0032-3861(97)10002-7 10.1002/1097-4628(20001114)78:7<1381::AID-APP90>3.0.CO;2-M 10.1016/j.reactfunctpolym.2006.02.006 10.1002/apmc.1984.051230121 10.1016/S0939-6411(99)00039-9 10.1016/S1381-5148(98)00031-5 10.1021/ma960685g 10.1021/ma60026a013 10.1021/ma9710803 10.1016/j.ijpharm.2007.12.029 10.1021/ma00125a040 10.1016/j.biomaterials.2005.09.028 10.1021/ma970894g |
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| SubjectTerms | Chemical engineering Copolymers Graft copolymers Hydrophobicity hydroxylpropyl cellulose micelle Micelles pH sensitive pH双敏感性 Synthesis Theophylline thermosensitive 新型接枝共聚物 |
| Title | Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers |
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