Synthesis and Characterization of Novel Temperature and pH Responsive Hydroxylpropyl Cellulose-based Graft Copolymers

• Published in: Chinese journal of chemical engineering Vol. 17; no. 1; pp. 145 - 149
• Main Author: 李小军 尹明辉 张国亮 张凤宝
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.02.2009
• Subjects: Chemical engineering; Copolymers; Graft copolymers; Hydrophobicity; hydroxylpropyl cellulose; micelle; Micelles; pH sensitive; pH双敏感性; Synthesis; Theophylline; thermosensitive; 新型接枝共聚物; pH sensitive; micelle; thermosensitive; theophylline; hydroxylpropyl cellulose
• ISSN: 1004-9541; 2210-321X
• DOI: 10.1016/S1004-9541(09)60046-X

In this study, double-hydrophilic hydroxylpropyl cellulose （HPC） based copolymers with poly（N- isopropylacrylamide） （PNIPAM） and poly（acrylic acid） （PAA） as graft chains were synthesized and characterized. The release behavior of drug-loaded micelles was studied. The results show that the hydrophilicity of copolymers improves as the pH increases, whereas the hydrophobicity of copolymers enhances as the temperature increases, and all the phase behaviors are reversible. The diameter of micelles decreases and then increases with pH increase. It shows different micellizing behavior under acidic and basic conditions according to the temperature increase. In vitro release experiments, which used theophylline as a model drug, show that the micelles enhance pH sensitivity in the release process.