The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease

• Published in: Experimental biology and medicine (Maywood, N.J.) Vol. 236; no. 10; p. 1116
• Main Authors: He, Jinhan, Lee, Jung Hoon, Febbraio, Maria, Xie, Wen
• Format: Journal Article
• Language: English
• Published: England 01.10.2011
• Subjects: Animals; CD36 Antigens - metabolism; CD36 Antigens - physiology; Fatty Liver - enzymology; Fatty Liver - metabolism; Gene Expression Regulation, Enzymologic - physiology; Humans; Liver - enzymology; Liver - metabolism; Receptors, Aryl Hydrocarbon - metabolism; Receptors, Aryl Hydrocarbon - physiology; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, Cytoplasmic and Nuclear - physiology

The fatty acid translocase (FAT)/CD36 belongs to the class B scavenger receptor family. In addition to the known functions of CD36 in the uptake of oxidized low-density lipoprotein by macrophages and uptake of fatty acids by adipose tissues, skeletal muscle and heart, emerging evidence has pointed t...