Effects of lipopolysaccharide on maturation of bovine oocyte in vitro and its possible mechanisms

• Published in: Oncotarget Vol. 8; no. 3; pp. 4656 - 4667
• Main Authors: Zhao, Shan-Jiang, Pang, Yun-Wei, Zhao, Xue-Ming, Du, Wei-Hua, Hao, Hai-Sheng, Zhu, Hua-Bin
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 17.01.2017
• Subjects: Animals; Cattle; Cell Cycle - drug effects; DNA Methylation - drug effects; Epigenesis, Genetic - drug effects; Female; Gene Expression Regulation - drug effects; Histones - metabolism; In Vitro Oocyte Maturation Techniques; Lipopolysaccharides - pharmacology; Mitogen-Activated Protein Kinases - metabolism; Oocytes - cytology; Oocytes - drug effects; Oocytes - metabolism; Oxidative Stress; Phosphorylation; Reactive Oxygen Species - metabolism; Research Paper; Spindle Apparatus - drug effects; epigenetic modifications; oocyte; lipopolysaccharide; cytoskeleton; oxidative stress

Lipopolysaccharide disturbs the secretion of gonadotropin, endometrial function and implantation efficiency. However, there is little information regarding the effects of lipopolysaccharide on cyclic ovary activity, especially oocyte maturation. Therefore, we aimed to investigate the effects of lipo...