Clinical Factors Associated With Chronic Pain in Communicative Adults With Cerebral Palsy: A Cross-Sectional Study

Chronic pain is prevalent in adults with cerebral palsy. We aimed to explore associations between chronic pain and somatosensory, motor, cognitive, etiologic, and environmental factors in adults with cerebral palsy. This cross-sectional study enrolled 17 adult participants with cerebral palsy (mean...

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Published inFrontiers in pain research (Lausanne, Switzerland) Vol. 1; p. 553026
Main Authors Chin, Eric M, Lenz, Colleen, Ye, Xiaobu, Campbell, Claudia M, Stashinko, Elaine, Jantzie, Lauren L, Gerner, Gwendolyn, Hoon, Alexander H, Robinson, Shenandoah
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.11.2020
Subjects
Pain Research
cerebral palsy
chronic pain mechanisms
adults with cerebral palsy
cerebral palsy and pain
sensorimotor dysfunction
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Abstract Chronic pain is prevalent in adults with cerebral palsy. We aimed to explore associations between chronic pain and somatosensory, motor, cognitive, etiologic, and environmental factors in adults with cerebral palsy. This cross-sectional study enrolled 17 adult participants with cerebral palsy (mean age 31 years; 8 female; Gross Motor Functional Classification Status levels I-V) able to self-report and 10 neurotypical adult volunteers (mean age 34 years; 9 female). Participants reported pain characteristics, demographics, and affective factors. Physical examination included somatosensory and motor evaluation. Between-group comparisons used a ranksum test, and correlation analyses estimated effect size in terms of shared variance (ρ ). Individuals with cerebral palsy reported greater pain intensity, neuropathic qualities, and nociceptive qualities than control participants. Higher pain intensity was associated with female gender (ρ = 16%), anxiety/depression symptoms (ρ = 10%), and lower household income (ρ = 19%). It was also associated with better communicative ability (ρ = 21%), spinothalamic (sharp/temperature) sensory abnormalities (ρ = 33%), and a greater degree of prematurity (ρ = 17%). This study highlights similarity of chronic pain associations in people with cerebral palsy with patterns seen in other populations with chronic pain. Spinothalamic sensory abnormalities suggest central pain mechanisms.
AbstractList Chronic pain is prevalent in adults with cerebral palsy. We aimed to explore associations between chronic pain and somatosensory, motor, cognitive, etiologic, and environmental factors in adults with cerebral palsy. This cross-sectional study enrolled 17 adult participants with cerebral palsy (mean age 31 years; 8 female; Gross Motor Functional Classification Status levels I-V) able to self-report and 10 neurotypical adult volunteers (mean age 34 years; 9 female). Participants reported pain characteristics, demographics, and affective factors. Physical examination included somatosensory and motor evaluation. Between-group comparisons used a ranksum test, and correlation analyses estimated effect size in terms of shared variance (ρ 2 ). Individuals with cerebral palsy reported greater pain intensity, neuropathic qualities, and nociceptive qualities than control participants. Higher pain intensity was associated with female gender (ρ 2 = 16%), anxiety/depression symptoms (ρ 2 = 10%), and lower household income (ρ 2 = 19%). It was also associated with better communicative ability (ρ 2 = 21%), spinothalamic (sharp/temperature) sensory abnormalities (ρ 2 = 33%), and a greater degree of prematurity (ρ 2 = 17%). This study highlights similarity of chronic pain associations in people with cerebral palsy with patterns seen in other populations with chronic pain. Spinothalamic sensory abnormalities suggest central pain mechanisms.
Chronic pain is prevalent in adults with cerebral palsy. We aimed to explore associations between chronic pain and somatosensory, motor, cognitive, etiologic, and environmental factors in adults with cerebral palsy. This cross-sectional study enrolled 17 adult participants with cerebral palsy (mean age 31 years; 8 female; Gross Motor Functional Classification Status levels I-V) able to self-report and 10 neurotypical adult volunteers (mean age 34 years; 9 female). Participants reported pain characteristics, demographics, and affective factors. Physical examination included somatosensory and motor evaluation. Between-group comparisons used a ranksum test, and correlation analyses estimated effect size in terms of shared variance (ρ ). Individuals with cerebral palsy reported greater pain intensity, neuropathic qualities, and nociceptive qualities than control participants. Higher pain intensity was associated with female gender (ρ = 16%), anxiety/depression symptoms (ρ = 10%), and lower household income (ρ = 19%). It was also associated with better communicative ability (ρ = 21%), spinothalamic (sharp/temperature) sensory abnormalities (ρ = 33%), and a greater degree of prematurity (ρ = 17%). This study highlights similarity of chronic pain associations in people with cerebral palsy with patterns seen in other populations with chronic pain. Spinothalamic sensory abnormalities suggest central pain mechanisms.
Author Lenz, Colleen
Ye, Xiaobu
Campbell, Claudia M
Gerner, Gwendolyn
Jantzie, Lauren L
Robinson, Shenandoah
Stashinko, Elaine
Chin, Eric M
Hoon, Alexander H
AuthorAffiliation 5 Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Center , Baltimore, MD , United States
2 Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD , United States
4 Department of Neurosurgery, Johns Hopkins University School of Medicine , Baltimore, MD , United States
6 Department of Neurology, Johns Hopkins University School of Medicine , Baltimore, MD , United States
1 Department of Neurology and Developmental Medicine, Kennedy Krieger Institute , Baltimore, MD , United States
7 Department of Neuropsychology, Kennedy Krieger Institute , Baltimore, MD , United States
3 Phelps Center for Cerebral Palsy and Neurodevelopmental Medicine, Department of Neurology and Developmental Medicine, Kennedy Krieger Institute , Baltimore, MD , United States
AuthorAffiliation_xml – name: 2 Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD , United States
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crossref_primary_10_3390_toxins15020152
crossref_primary_10_36106_gjra_6504764
crossref_primary_10_1002_cns3_20047
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Copyright Copyright © 2020 Chin, Lenz, Ye, Campbell, Stashinko, Jantzie, Gerner, Hoon and Robinson.
Copyright © 2020 Chin, Lenz, Ye, Campbell, Stashinko, Jantzie, Gerner, Hoon and Robinson. 2020 Chin, Lenz, Ye, Campbell, Stashinko, Jantzie, Gerner, Hoon and Robinson
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Keywords cerebral palsy
chronic pain mechanisms
adults with cerebral palsy
cerebral palsy and pain
sensorimotor dysfunction
Language English
License Copyright © 2020 Chin, Lenz, Ye, Campbell, Stashinko, Jantzie, Gerner, Hoon and Robinson.
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Edited by: Vasco Galhardo, University of Porto, Portugal
This article was submitted to Neuropathic Pain, a section of the journal Frontiers in Pain Research
Reviewed by: Edita Navratilova, University of Arizona, United States; Ajda Bedene, Leiden University Medical Center, Netherlands
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Snippet Chronic pain is prevalent in adults with cerebral palsy. We aimed to explore associations between chronic pain and somatosensory, motor, cognitive, etiologic,...
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Title Clinical Factors Associated With Chronic Pain in Communicative Adults With Cerebral Palsy: A Cross-Sectional Study
URI https://www.ncbi.nlm.nih.gov/pubmed/35295692
https://search.proquest.com/docview/2640326904
https://pubmed.ncbi.nlm.nih.gov/PMC8915712
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