Proteasome activity correlates with male BMI and contributes to the differentiation of adipocyte in hADSC

• Published in: Endocrine Vol. 37; no. 2; pp. 274 - 279
• Main Authors: Sakamoto, Kozue, Sato, Youichi, Sei, Masako, Ewis, Ashraf A, Nakahori, Yutaka
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.04.2010; Springer US
• Subjects: Adipocytes - cytology; Adipocytes - drug effects; Adipocytes - metabolism; Adipogenesis - drug effects; Adipogenesis - physiology; Adult; Asian Continental Ancestry Group; Body Mass Index; Cell Differentiation - drug effects; Cell Differentiation - physiology; Cell Survival - drug effects; Cell Survival - physiology; Cells, Cultured; Cysteine Proteinase Inhibitors - pharmacology; Diabetes; Endocrinology; Humanities and Social Sciences; Humans; Internal Medicine; Leupeptins - pharmacology; Male; Medicine; Medicine & Public Health; multidisciplinary; Obesity - metabolism; Obesity - physiopathology; Original Article; Proteasome Endopeptidase Complex - blood; Proteasome Inhibitors; Science; Stem Cells - cytology; Stem Cells - drug effects; Stem Cells - metabolism; Obesity; Proteasome activities; hADSC; BMI; Adipogenesis

We have previously reported that 26S proteasome subunit mRNA expressions correlate with male body mass index (BMI). In this study, to investigate whether proteasome activities are correlated with BMI, we recruited 61 healthy young Japanese male subjects, measured proteasome activities in their plasm...